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Serpins constitute a superfamily of proteins that possess a unique tertiary structure and mechanism of proteinase inhibition. In humans, serpins constitute 10% of the plasma proteins and are best known as critical regulators of both the thrombotic and fibrinolytic systems. Serpins also participate in the regulation of the complement cascade, angiogenesis, tumor metastasis, apoptosis and innate immunity. Considering the importance of these molecules in regulating proteolytic cascades, it is not surprising to find that loss- and gain-of-function mutations result in significant human diseases. Ma

Serpins. --- Serpins --- Serine proteinases --- Physiological effect. --- Inhibitors

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HEMORRHAGIC DIATHESIS --- HEMOSTASIS --- FIBRINOLYSIS --- THROMBOSIS --- HEMORRHAGE --- NEOPLASMS --- CARDIOLIPINS --- SERPINS

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Serine proteases play significant roles in healh and human disease. Abnormal expression and activities of serine proteases have been linked to the pathogenesis of many diseases. The book presents correlation between serine proteases and human diseases. It helps the reader understand classification, catalytic mechanism and types of serine proteases and their role in human disease pathogenesis at mechanistic level. The chapters explain the role of serine proteases in various diseases including respiratory disorders and cancer. It also covers the therapeutic importance of serine proteases as drug target and explains the mechanistic insights of serine proteases inhibitors. Serine protease are known to play crucial role in biological processes but disturbance in their equilibrium can result in serious health conditions. To maintain homeostasis, serine protease inhibitors come in action and inhibit proteases. Several serine protease inhibitors have been identified and many more are being designed as novel compounds for inhibitions of proteases that provide management of comorbidities. Therefore, this book will serve as a useful reference for students and researchers to understand physiological role of serine proteases and their association with initiation and progression of human diseases. It will also help to develop some strategies to develop serine proteases inhibitors as drug target of serine proteases at cellular and molecular level.

Serine proteinases. --- Serpins. --- Blood Coagulation. --- Cancer. --- Digestion. --- Immune Responses. --- Respiratory Disorders. --- Serine Protease Inhibitors.

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Serpins are a group of proteins with similar structures that were first identified as a set of proteins able to inhibit proteases. This volume in the Methods in Enzymology series comprehensively covers this topic. With an international board of authors, this volume covers subjects such Crystallography of serpins and serpin complexes, Serpins as hormone transporters, and Production of serpins using cell free systems This volume in the Methods in Enzymology series comprehensively covers the topic of Serpins. With an international board of authors, this volume covers sub

Enzymes -- Regulation. --- Serpins -- Therapeutic use. --- Serpins. --- Proteins --- Proteinase Inhibitory Proteins, Secretory --- Peptides --- Amino Acids, Peptides, and Proteins --- Chemicals and Drugs --- Serpins --- Human Anatomy & Physiology --- Health & Biological Sciences --- Animal Biochemistry --- Therapeutic use. --- therapeutic use. --- Clinical enzymology. --- Diagnostic enzymology --- Clinical chemistry --- Enzymology --- Serine proteinases --- Inhibitors

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Serpins are a group of proteins with similar structures that were first identified as a set of proteins able to inhibit proteases. The acronym serpin was originally coined because many serpins inhibit chymotrypsin-like serine proteases. This volume of Methods in Ezymology is split into 2 parts and comprehensively covers the subject.

Protein folding. --- Proteins -- Biotechnology. --- Proteins. --- Serpins. --- Biophysical Processes --- Peptides --- Biochemical Processes --- Proteins --- Mice --- Animals, Genetically Modified --- Investigative Techniques --- Proteinase Inhibitory Proteins, Secretory --- Murinae --- Animal Population Groups --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Biochemical Phenomena --- Biophysical Phenomena --- Physical Processes --- Amino Acids, Peptides, and Proteins --- Chemical Processes --- Physical Phenomena --- Animals --- Muridae --- Chemicals and Drugs --- Chemical Phenomena --- Phenomena and Processes --- Rodentia --- Eukaryota --- Organisms --- Mammals --- Vertebrates --- Chordata --- Serpins --- Mice, Transgenic --- Models, Animal --- Protein Folding --- Human Anatomy & Physiology --- Health & Biological Sciences --- Animal Biochemistry --- Biotechnology. --- Protease inhibitors. --- Clinical enzymology. --- Diagnostic enzymology --- Proteolytic enzyme inhibitors --- Proteolytic enzymes --- Inhibitors --- Clinical chemistry --- Enzymology --- Enzyme inhibitors