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Gastrointestinal cancers represent a heterogeneous group of diseases of the gastrointestinal tract. There is an interplay of various non-modifiable and modifiable risk factors that foster the conversion of normal cells to precursor cells, precursor cells to premalignant cells, and premalignant cells to malignant cells. Gastrointestinal cancers are diverse in etiology and clinical management. The chapters of this book explore the clinically relevant aspects of this diversity under three broad categories: epidemiology and pathology, early diagnosis and prognosis, and surgical management. The etiological aspects focus on stomach cancer while the pathological aspects provide an overview of colorectal cancer, how primary colorectal cancer becomes metastatic through epithelial mesenchymal transition, and how macrophage-derived extracellular vesicles drive tumor development and enable the progression of most gastrointestinal cancers. Chapters on early detection and prognosis emphasize on biomarker discovery, both at genetic and proteomic level, and how these can be used to effectively predict the origin, progress, prognosis, and treatment response of gastrointestinal cancers in general and pancreatic cancer in particular. Given that the gastrointestinal tract is solely responsible for the processing of the diet we consume, the impact of diet that we consume cannot be ignored. There is a dedicated chapter that covers the role of diet and lifestyle on colorectal cancer incidence and survival. Despite various treatment modalities, for localized cancers, surgery is still the best form of curative treatment, and the role of surgical management of gastrointestinal stromal tumors and esophageal cancers are elegantly summarized in two chapters. The contents of this book provide the readers with an overview of several important aspects of gastrointestinal cancers and may be of interest to healthcare professionals interested in gastrointestinal cancers.

MJCL --- gastrointestinal cancers --- stomach cancer --- pancreatic cancer --- colorectal cancer --- gastrointestinal stromal tumors --- esophageal cancer

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Gastrointestinal cancers represent a heterogeneous group of diseases of the gastrointestinal tract. There is an interplay of various non-modifiable and modifiable risk factors that foster the conversion of normal cells to precursor cells, precursor cells to premalignant cells, and premalignant cells to malignant cells. Gastrointestinal cancers are diverse in etiology and clinical management. The chapters of this book explore the clinically relevant aspects of this diversity under three broad categories: epidemiology and pathology, early diagnosis and prognosis, and surgical management. The etiological aspects focus on stomach cancer while the pathological aspects provide an overview of colorectal cancer, how primary colorectal cancer becomes metastatic through epithelial mesenchymal transition, and how macrophage-derived extracellular vesicles drive tumor development and enable the progression of most gastrointestinal cancers. Chapters on early detection and prognosis emphasize on biomarker discovery, both at genetic and proteomic level, and how these can be used to effectively predict the origin, progress, prognosis, and treatment response of gastrointestinal cancers in general and pancreatic cancer in particular. Given that the gastrointestinal tract is solely responsible for the processing of the diet we consume, the impact of diet that we consume cannot be ignored. There is a dedicated chapter that covers the role of diet and lifestyle on colorectal cancer incidence and survival. Despite various treatment modalities, for localized cancers, surgery is still the best form of curative treatment, and the role of surgical management of gastrointestinal stromal tumors and esophageal cancers are elegantly summarized in two chapters. The contents of this book provide the readers with an overview of several important aspects of gastrointestinal cancers and may be of interest to healthcare professionals interested in gastrointestinal cancers.

gastrointestinal cancers --- stomach cancer --- pancreatic cancer --- colorectal cancer --- gastrointestinal stromal tumors --- esophageal cancer

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Stomach --- Stomach Neoplasms. --- Tumors --- Diseases --- Diseases. --- Tumors. --- Gastric diseases --- Cancer of the Stomach --- Gastric Cancer, Familial Diffuse --- Neoplasms, Gastric --- Neoplasms, Stomach --- Cancer of Stomach --- Gastric Cancer --- Gastric Neoplasms --- Stomach Cancer --- Cancer, Gastric --- Cancer, Stomach --- Cancers, Gastric --- Cancers, Stomach --- Gastric Cancers --- Gastric Neoplasm --- Neoplasm, Gastric --- Neoplasm, Stomach --- Stomach Cancers --- Stomach Neoplasm --- Stomach Neoplasms --- Abdomen --- Gastrointestinal system --- Oncology

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Although there has been a slow but steady decrease in incidence, gastric cancer remains the second leading cause of cancer death worldwide. Several aspects of the oncological and surgical management are still controversial and so gastric cancer represents a challenge for the surgeon. This book aims to delineate the state of the art in the surgical and oncological treatment of gastric cancer, describing the new TNM staging system, the extent of visceral resection and lymphadenectomy focusing on the different open and minimally invasive surgical techniques and discussing intraoperative chemohyperthermia and neoadjuvant and adjuvant treatment. Operative endoscopy and endoscopic ultrasonography are also discussed, as these now have an important role in both diagnostic work-up and palliative care of gastric cancer patients. Only a multidisciplinary approach involving the surgeon, gastroenterologist, and oncologist can produce the comprehensive and integrated overview that today constitutes a winning strategy for the optimization of results.What we hope we have achieved is a flexible, up-to-date, exhaustive publication, rich in illustrations and consistent with evidence-based medicine.

Stomach -- Cancer. --- Therapeutics --- Gastrointestinal Neoplasms --- Surgical Procedures, Operative --- Stomach Diseases --- Digestive System Neoplasms --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Gastrointestinal Diseases --- Digestive System Diseases --- Neoplasms by Site --- Diseases --- Neoplasms --- Stomach Neoplasms --- Digestive System Surgical Procedures --- Combined Modality Therapy --- Surgery & Anesthesiology --- Medicine --- Health & Biological Sciences --- Surgery - General and By Type --- Oncology --- Stomach --- Cancer. --- Surgery. --- Gastrotomy --- Medicine. --- Gastroenterology. --- Oncology. --- Abdominal surgery. --- Surgical oncology. --- Medicine & Public Health. --- Abdominal Surgery. --- Surgical Oncology. --- Abdomen --- Oncology  . --- Internal medicine --- Digestive organs --- Cancer --- Oncologic surgery --- Oncological surgery --- Surgical oncology --- Abdominal surgery --- Laparotomy --- Surgery, Primitive --- Tumors --- Excision --- Treatment --- Gastroenterology .

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This book highlights the importance of understanding gastric and colon cancer metabolism in guiding diagnosis and drug discovery. It summarizes the correlation between adiponectin and matrix metalloproteinase with colorectal cancer. The book also evaluates the divergent role of hypoxia-inducible factor 1 in colorectal cancer growth and metastasis. After discussing the role of genetic polymorphisms in alcohol metabolizing enzymes and EPHX1 with the onset of colorectal cancer, it reviews the molecular mechanisms of chemoresistance in gastric cancer and novel therapeutic strategies to reverse the chemoresistance of tumors. In addition, the book explores the theranostic role of nanoparticles and therapeutic potential of phytochemicals with regard to colorectal cancer. Given its scope, the book offers a valuable guide for oncologists, academic researchers, pharmaceuticals practitioners, and students who are involved in research and treatment of cancer.

Cancer research. --- Gastroenterology . --- Oncology  . --- Genetics. --- Cancer Research. --- Gastroenterology. --- Oncology. --- Genetics and Genomics. --- Biology --- Embryology --- Mendel's law --- Adaptation (Biology) --- Breeding --- Chromosomes --- Heredity --- Mutation (Biology) --- Variation (Biology) --- Tumors --- Internal medicine --- Digestive organs --- Cancer research --- Diseases --- Stomach --- Cancer. --- Colonic Neoplasms. --- Stomach Neoplasms. --- Cancer of the Stomach --- Gastric Cancer, Familial Diffuse --- Neoplasms, Gastric --- Neoplasms, Stomach --- Cancer of Stomach --- Gastric Cancer --- Gastric Neoplasms --- Stomach Cancer --- Cancer, Gastric --- Cancer, Stomach --- Cancers, Gastric --- Cancers, Stomach --- Gastric Cancers --- Gastric Neoplasm --- Neoplasm, Gastric --- Neoplasm, Stomach --- Stomach Cancers --- Stomach Neoplasm --- Cancer of the Colon --- Colon Neoplasms --- Colonic Cancer --- Neoplasms, Colonic --- Cancer of Colon --- Colon Cancer --- Cancer, Colon --- Cancer, Colonic --- Cancers, Colon --- Cancers, Colonic --- Colon Cancers --- Colon Neoplasm --- Colonic Cancers --- Colonic Neoplasm --- Neoplasm, Colon --- Neoplasm, Colonic --- Neoplasms, Colon