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Carcinogenesis --- Target organs (Anatomy) --- Cancer --- Carcinogens. --- Molecular aspects. --- Chemotherapy.
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This book introduces readers to intestinal and epidermal barriers, and to toxicity induction of environmental toxicants or stresses in the intestine, epidermis, neurons, muscle, and reproductive organs in Caenorhabditis elegans. In addition, it discusses the protective responses of various organs and nematodes’ avoidance behaviour with regard to environmental toxicants or stresses. The intestinal, epidermal, neuronal, and germline signalling pathways required for the regulation of toxicity of environmental toxicants or stresses are also introduced and discussed. As a classic model animal with well-described genetic and developmental backgrounds, the nematode Caenorhabditis elegans has been successfully and widely used in both toxicity assessments and toxicological studies on various environmental toxicants and stresses. Once exposure to certain environmental toxicants has occurred, the toxicants can enter into the primary targeted organs (such as intestinal cells), and even be translocated into secondary targeted organs (such as reproductive organs and neurons). Based on related available data, this book provides a systematic understanding of target organ toxicology in C. elegans.
Toxicology. --- Cytology. --- Invertebrates. --- Pharmacology/Toxicology. --- Cell Biology. --- Target organs (Anatomy) --- Organs (Anatomy) --- Drug targeting
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Drug targeting. --- Nanomedicine. --- Medicine --- Nanotechnology --- Drugs --- Site-specific drug delivery --- Targeting of drugs --- Target organs (Anatomy) --- Targeting --- Dosage forms
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Drug targeting. --- Nanomedicine. --- Medicine --- Nanotechnology --- Drugs --- Site-specific drug delivery --- Targeting of drugs --- Target organs (Anatomy) --- Targeting --- Dosage forms
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The development of monoclonal antibodies and other inhibitors of specific molecules, fully utilizing the insights learned from molecular techniques such as comparative microarrays and protein expression patterns, has led to the development and FDA approval of several agents for the treatment of breast cancer, such as trastuzamab (Herceptin, targeting HER-2 positive tumors) and lapatinib (Tykerb, targeting tumors with mutated/overexpressed EGFR 1 and 2). Other agents specifically targeting the estrogen receptor, the aromatose pathway and microtubule dynamics, fulvestrant (Faslodex, targeting th
Breast --- Drug targeting --- Drugs --- Site-specific drug delivery --- Targeting of drugs --- Target organs (Anatomy) --- Breasts --- Chest --- Large-breasted women --- Cancer --- Treatment --- Targeting --- Dosage forms
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Cancer --- Drug targeting. --- Drugs --- Site-specific drug delivery --- Targeting of drugs --- Target organs (Anatomy) --- Antineoplastic agents --- Chemotherapy. --- Targeting --- Dosage forms --- Treatment
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Antiprotozoal agents. --- Antiprotozoals --- Antiprotozoan agents --- Antiprotozoans --- Antiparasitic agents --- Antiprotozoal agents --- Drug targeting --- Drugs --- Site-specific drug delivery --- Targeting of drugs --- Target organs (Anatomy) --- Targeting --- Dosage forms --- E-books
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From its introduction, oncological chemotherapy has been encumbered by its poor selectivity because most antiproliferative drugs are toxic not only to tumor cells but also to important populations of the body’s non-neoplastic cells. The resultant problems with unwanted side effects are compounded by difficulties in predicting the desired effectivity of chemotherapy in individual patients. This unsatisfactory situation has driven intensive research and development towards more specific and less toxic anticancer drugs over the last few decades. Several results of these efforts have reached the clinic and an even greater number are now in preclinical testing. Common to all these targeted therapies is their interaction with defined molecules present on cancer cells, which adds various degrees of increased selectivity to their toxic effects. As a consequence, detecting the target molecule on tumors before therapy holds great diagnostic potential for predicting the efficacy of the drug and personalizing therapy. This book aims to present translational scientists and clinicians with an integrated critical view on the theories, mechanisms, problems and pitfalls of the targeted therapy approach.
Cancer --- Drug targeting. --- Chemotherapy. --- Drugs --- Site-specific drug delivery --- Targeting of drugs --- Target organs (Anatomy) --- Antineoplastic agents --- Targeting --- Dosage forms --- Treatment --- Oncology . --- Oncology. --- Cancer Research. --- Tumors --- Cancer research. --- Cancer research
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The first comprehensive overview of the effects of hypertension on the brain. The book discusses not only the relationship between hypertension and stroke, but also the much less studied relationship between hypertension and cognitive decline and neurodegenerative diseases such as Alzheimer's. It seeks to answer two important questions. First, what are the conditions under which hypertension is associated with stroke, cognitive decline, and neurodegenerative disease? And second, what are the biological mechanisms by which hypertension alters brain homeostasis? By looking at the biological mechanisms of these relationships, this book provides insight to neuroscientists and neurologists regarding why anti-hypertension treatments make a big difference in the case of stroke, but have very little impact on cognitive decline and brain aging.
Neurology --- Medicine --- Health & Biological Sciences --- Hypertension --- Target organs (Anatomy) --- Complications. --- Blood pressure, High --- High blood pressure --- Vascular hypertension --- Organs (Anatomy) --- Drug targeting --- Blood circulation disorders --- Neurosciences. --- Neurology. --- Nervous system --- Neuropsychiatry --- Neural sciences --- Neurological sciences --- Neuroscience --- Medical sciences --- Diseases --- Neurology .
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Since the year 2000, exciting developments in cancer therapy have occurred. For decades in the 20th century, the hallmark of medical treatment for cancer had been cytotoxic chemotherapy, with drugs targeting rapidly dividing cells, including cancer cells but also certain normal tissues. As a result, many patients experienced the ""classic"" toxicities of alopecia, gastrointestinal symptoms and/or myelosuppression. In the last years, however, clinical research has been strongly occupied with the identification of mutations and aberrations concerning molecular pathways in cancer and their altera
Cancer --- Treatment --- Drug targeting. --- Antineoplastic agents. --- Anticancer agents --- Antineoplastic drugs --- Antineoplastics --- Antitumor agents --- Antitumor drugs --- Cytotoxic drugs --- Inhibitors, Neoplasm --- Neoplasm inhibitors --- Drugs --- Site-specific drug delivery --- Targeting of drugs --- Target organs (Anatomy) --- Antineoplastic agents --- Chemotherapy. --- Chemotherapy --- Targeting --- Dosage forms
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