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This volume provides readers with the most updated scientific information on the efficacy and safety of medicines for children and adolescents. The book enriches the understanding of pediatric pharmacotherapy for health professionals, regulatory agencies, pharmaceutical companies and learned societies. It contains important information on the pharmacodynamics and pharmacokinetics of drugs. It summarizes the latest investigations on the effects of pharmacological treatments in relation to and dependent on age, gender, fat mass and disease status. Therefore and importantly, this volume reviews the latest data on how pharmacotherapy has to be adjusted and personalized in regards to stages of development and during the pediatric lifespan from neonate through adolescence. In addition, the topic of rare diseases and special challenges for pharmacotherapy will be included and will provide readers with the necessary knowledge to handle complex diseases and treatment strategies especially in relation to pharmacotherapy of rare and orphan diseases.

Pharmacology. --- Pediatrics. --- Pharmacology/Toxicology. --- Paediatrics --- Pediatric medicine --- Medicine --- Children --- Drug effects --- Medical pharmacology --- Medical sciences --- Chemicals --- Chemotherapy --- Drugs --- Pharmacy --- Diseases --- Health and hygiene --- Physiological effect --- Pediatric pharmacology. --- Pharmacology --- Effect of drugs on --- Quimioteràpia --- Pediatria --- Medicina --- Cirurgia infantil --- Dietoteràpia per a infants --- Ginecologia pediàtrica --- Hematologia pediàtrica --- Hepatologia pediàtrica --- Infants malalts --- Infermeria pediàtrica --- Neonatologia --- Odontologia infantil --- Otorrinolaringologia pediàtrica --- Pediatria veterinària --- Perinatologia --- Pneumologia pediàtrica --- Puericultura --- Radiologia pediàtrica --- Urologia pediàtrica --- Farmacologia pediàtrica --- Malalties dels infants --- Farmacoteràpia --- Immunoquimioteràpia --- Terapèutica medicamentosa --- Terapèutica per agents químics (Medicina) --- Tractament amb medicaments --- Tractament per agents químics (Medicina) --- Us terapèutic dels medicaments --- Terapèutica --- Administració de medicaments --- Antibiòtics --- Diürètics --- Fotoquimioteràpia --- Pirogens --- Psicofarmacologia --- Prescripció de medicaments --- Quimioteràpia del càncer --- Utilització de medicaments --- Farmacologia --- Medicaments

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Renal pharmacology. --- Drugs --- Dosage. --- Metabolism. --- Kidneys --- Kidneys, Effect of drugs on --- Pharmacology --- Drug metabolism --- Pharmacokinetics --- Dosage of drugs --- Dosiology --- Microdosage of drugs --- Posology --- Drug effects --- Effect of drugs on --- Microdosage --- Administration --- Quimioteràpia --- Posologia --- Metabolisme dels medicaments --- Farmacoteràpia --- Immunoquimioteràpia --- Terapèutica medicamentosa --- Terapèutica per agents químics (Medicina) --- Tractament amb medicaments --- Tractament per agents químics (Medicina) --- Us terapèutic dels medicaments --- Terapèutica --- Administració de medicaments --- Antibiòtics --- Diürètics --- Fotoquimioteràpia --- Pirogens --- Psicofarmacologia --- Prescripció de medicaments --- Quimioteràpia del càncer --- Utilització de medicaments --- Farmacologia --- Medicaments --- Metabolisme de fàrmacs --- Farmacocinètica --- Dosimetria --- Dosificació de medicaments --- Aritmètica farmacèutica --- Prospectes de medicaments

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This book is a thorough, practical review of the challenges facing clinicians treating skin microbes and how to combat these therapeutic dilemmas. It expresses the critical public health concern of antimicrobial resistance and shows how microorganisms are developing the ability to halt the progress of antimicrobials like antibiotics, antivirals, and antifungals. Chapters are grouped together in five sections for ease of use. The first three sections of the book convey foundational information on the mechanisms of antibiotics, antivirals, and antifungals resistance, as well as the implications of lack of vaccination. The fourth section then turns to the specifics of drug resistance for protozoan and helminth infections focusing primarily on initial and subsequent resistance to treatment. The book closes with a discussion on the potential solutions of innovative therapy including new delivery mechanisms, broad-spectrum antibiotics, phytocompounds, and biofilms. Chapters feature magnified, microscopic photos for identifying structures as they appear on the skin. Part of the Updates in Clinical Dermatology series, Overcoming Antimicrobial Resistance of the Skin is an important resource relevant during the COVID-19 pandemic, and is written for all medical healthcare professionals.

Dermatology. --- Medicine --- Skin --- Diseases --- Treatment. --- Microbiology. --- Cutis --- Integument (Skin) --- Beauty, Personal --- Body covering (Anatomy) --- Malalties de la pell --- Microbiologia --- Quimioteràpia --- Farmacoteràpia --- Immunoquimioteràpia --- Terapèutica medicamentosa --- Terapèutica per agents químics (Medicina) --- Tractament amb medicaments --- Tractament per agents químics (Medicina) --- Us terapèutic dels medicaments --- Terapèutica --- Administració de medicaments --- Antibiòtics --- Diürètics --- Fotoquimioteràpia --- Pirogens --- Psicofarmacologia --- Prescripció de medicaments --- Quimioteràpia del càncer --- Utilització de medicaments --- Farmacologia --- Medicaments --- Biologia --- Bacteriologia --- Ecologia microbiana --- Genètica microbiana --- Microbiologia agrícola --- Microbiologia aquàtica --- Microbiologia dels sòls --- Microbiologia mèdica --- Microbiologia molecular --- Protozous --- Química microbiològica --- Virologia --- Microorganismes --- Microscòpia --- Dermatopaties --- Dermatosis --- Malalties --- Càncer de pell --- Ceratosi --- Dermatotoxicologia --- Erisipela --- Fotodermatosis --- Liquen pla --- Lupus eritematós --- Malaltia de Behçet --- Malalties de la pell en els animals --- Malalties de les ungles --- Manifestacions cutànies de les malalties --- Parapsoriasi --- Pecilodèrmia --- Pèmfig --- Psoriasi --- Ronya --- Trastorns de la pigmentació --- Dermatologia --- Urticària

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This book provides a broad overview of rare disease drug development. It offers unique insights from various perspectives, including third-party capital providers, caregivers, patient advocacy groups, drug development professionals, marketing and commercial experts, and patients. A unique reference, the book begins with narratives on the many challenges faced by rare disease patient and their caregivers. Subsequent chapters underscore the critical, multidimensional role of patient advocacy groups and the novel approaches to related clinical trials, investment decisions, and the optimization of rare disease registries. The book addresses various rare disease drug development processes by disciplines such as oncology, hematology, pediatrics, and gene therapy. Chapters then address the operational aspects of drug development, including approval processes, development accelerations, and market access strategies. The book concludes with reflections on the authors' case for real-world data and evidence generation in orphan medicinal drug development. Rare Disease Drug Development is an expertly written text optimized for biopharmaceutical R&D experts, commercial experts, third-party capital providers, patient advocacy groups, patients, and caregivers.

Drug development. --- Rare diseases --- Chemotherapy. --- Rare disorders --- Uncommon diseases --- Diseases --- Development of drugs --- Drugs --- New drug development --- Pharmacology --- Pharmacy --- Development --- Malalties rares --- Desenvolupament de medicaments --- Quimioteràpia --- Farmacoteràpia --- Immunoquimioteràpia --- Terapèutica medicamentosa --- Terapèutica per agents químics (Medicina) --- Tractament amb medicaments --- Tractament per agents químics (Medicina) --- Us terapèutic dels medicaments --- Terapèutica --- Administració de medicaments --- Antibiòtics --- Diürètics --- Fotoquimioteràpia --- Pirogens --- Psicofarmacologia --- Prescripció de medicaments --- Quimioteràpia del càncer --- Utilització de medicaments --- Farmacologia --- Medicaments --- Farmàcia --- Disseny de medicaments --- Malalties --- Medicine. --- Clinical medicine --- Pharmacology. --- Immunology. --- Therapeutics. --- Pharmacovigilance. --- Clinical Medicine. --- Clinical Research. --- Drug Safety and Pharmacovigilance. --- Research. --- Pharmacoepidemiology --- Medical treatment --- Therapy --- Treatment of diseases --- Treatments for diseases --- Immunobiology --- Life sciences --- Serology --- Drug effects --- Medical pharmacology --- Medical sciences --- Chemicals --- Chemotherapy --- Health Workforce --- Physiological effect

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Malalties del sistema nerviós --- Quimioteràpia --- Farmacoteràpia --- Immunoquimioteràpia --- Terapèutica medicamentosa --- Terapèutica per agents químics (Medicina) --- Tractament amb medicaments --- Tractament per agents químics (Medicina) --- Us terapèutic dels medicaments --- Terapèutica --- Administració de medicaments --- Antibiòtics --- Diürètics --- Fotoquimioteràpia --- Pirogens --- Psicofarmacologia --- Prescripció de medicaments --- Quimioteràpia del càncer --- Utilització de medicaments --- Farmacologia --- Medicaments --- Malalties dels nervis --- Neuropatia --- Neuropatologia --- Trastorns del sistema nerviós --- Malalties --- Convulsions --- Infermeria neurològica --- Malalties del sistema nerviós autònom --- Malalties del sistema nerviós central --- Malalties neurodegeneratives --- Malalties neuromusculars --- Manifestacions neurològiques de les malalties --- Neurologia veterinària --- Neuropaties perifèriques --- Trastorns de la comunicació --- Trastorns de la percepció --- Trastorns motors --- Malformacions del sistema nerviós --- Nerves, Peripheral --- Drugs --- Diseases. --- Side effects. --- Adverse drug reactions --- Adverse reactions to drug therapy --- Chemotherapy --- Drug-induced disease --- Drug side effects --- Side effects of drugs --- Iatrogenic diseases --- Drug interactions --- Peripheral neuropathies --- Complications --- Adverse reactions --- Physiological effect --- Drug-Related Side Effects and Adverse Reactions. --- Peripheral Nervous System Diseases. --- Neurotoxicity Syndromes --- Antineoplastic Agents --- adverse effects. --- Adverse Drug Event --- Adverse Drug Reaction --- Drug Side Effects --- Drug Toxicity --- Side Effects of Drugs --- Toxicity, Drug --- Adverse Drug Events --- Adverse Drug Reactions --- Drug Event, Adverse --- Drug Events, Adverse --- Drug Reaction, Adverse --- Drug Reactions, Adverse --- Drug Related Side Effects and Adverse Reactions --- Drug Side Effect --- Drug Toxicities --- Effects, Drug Side --- Reactions, Adverse Drug --- Side Effect, Drug --- Side Effects, Drug --- Toxicities, Drug --- Drug Therapy --- Pharmaceutical Preparations --- Contraindications, Drug --- Drug Interactions --- Clinical Trials, Phase IV as Topic --- Encephalopathy, Toxic --- Nervous System Poisoning --- Neurotoxic Disorders --- Neurotoxin Diseases --- Neurotoxin Disorders --- Toxic Encephalitis --- Poisoning, Nervous System --- Encephalitides, Toxic --- Encephalitis, Toxic --- Encephalopathies, Toxic --- Nervous System Poisonings --- Neurotoxic Disorder --- Neurotoxicity Syndrome --- Neurotoxin Disease --- Neurotoxin Disorder --- Poisonings, Nervous System --- Syndrome, Neurotoxicity --- Syndromes, Neurotoxicity --- Toxic Encephalitides --- Toxic Encephalopathies --- Toxic Encephalopathy --- PNS (Peripheral Nervous System) Diseases --- PNS Diseases --- Peripheral Nervous System Disease --- Peripheral Nervous System Disorders --- Peripheral Nerve Diseases --- Peripheral Neuropathies --- Nerve Disease, Peripheral --- Nerve Diseases, Peripheral --- Neuropathy, Peripheral --- PNS Disease --- Peripheral Nerve Disease --- Peripheral Neuropathy --- adverse effects --- toxicity