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Book
Frontiers in Radiation Oncology
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ISBN: 9535171704 9535111639 Year: 2013 Publisher: IntechOpen

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Abstract

The mode of action by radiation is postulated to be the production of double strand breaks of DNA. The repair of double strand breaks occurs through non homologous end joining through acetylation of histone proteins by histone acetyltransferases (HATs). The fixation of double strand breaks through HAT inhibitors is a promising application for radiation sensitization in the clinic. P53 is a tumour suppressor gene and its mutation has been implicated in 60% of human cancers. As one of the pivotal anticancer genes, P53 controls the transcription and translation of a series of genes. The kinetics of DNA double strand break generation and their co relation to P53 status, ATM and ARF activation are computed and modelled for understanding the potential of such research.


Periodical
Journal européen de radiothérapie.
ISSN: 02431203 Publisher: Paris : Masson,

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Periodical
Journal of radiation and cancer research
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ISSN: 24689203 25889273 Publisher: India Wolters Kluwer Medknow Publications


Book
Clinical radiation oncology
Authors: ---
ISBN: 9780323370189 0323370187 9780323240987 0323240984 Year: 2016 Publisher: Philadelphia, Pennsylvania : Elsevier,

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Radiation oncology for physicians and residents needing a multidisciplinary, treatment-focused resource; this updated edition provides the latest knowledge in this consistently growing field. You will broaden your understanding of the basic biology of disease processes, and access updated treatment algorithms, information on techniques, and state-of-the-art modalities.


Periodical
Radiation oncology.
ISSN: 1748717X Year: 2006 Publisher: [London] : BioMed Central,


Book
Nuclear oncology : from pathophysiology to clinical applications
Author:
ISBN: 9783031054945 Year: 2022 Publisher: Cham, Switzerland : Springer,


Periodical
International journal of radiation oncology, biology, physics.

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