Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

The problem of clinical pain management is complex and far-reaching, as it encompasses many different types of pain, such as arthritis, musculoskeletal conditions, neuropathic pain, and visceral pain. The analgesics market is growing and the driving forces are the aging population and need for better therapeutic benefits. There are various analgesic products that are available that can be administered by various routes, yet research is active in identifying new technologies for better drug targeting and novel targets to gain improved therapeutic efficiency. It is widely known that many of the well-established analgesic pathways are centrally based, involving spinal and supraspinal sites. However, pain can also be effectively controlled by peripheral pathways. For example, peripheral endogenous analgesia can be elicited by immune cells entering inflamed tissue and releasing opioid peptides that activate up-regulated opioid receptors on sensory nerve terminals. Such analgesic effects are particularly prominent in painful inflammatory conditions and avoid central opioid side effects. In this Research Topic of Frontiers, we would like to bring together experts in the field of pain at the physiological, pharmacological and pharmaceutical levels to discuss novel pain targets and new pain technologies. The goal of this workshop is to generate collaborative discussion on the future and direction of pain therapies. Manuscripts describing original research, methods, hypothesis and theory, and reviews are welcomed.

Pathology --- Medicine --- Health & Biological Sciences --- Pain --- Analgesics --- Targeted Drug Delivery --- novel strategies --- Therapeutic target

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact

Medicine --- Immunology --- STAT --- IRF --- innate immunity --- inflammation --- transcriptional regulation --- therapeutic target

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

Pituitary adenomas are a category of neoplasms with a high degree of heterogeneity that occur in the central regulatory organ pituitary, which plays important roles in the hypothalamus–pituitary-targeted organ axis systems that impact on important physiological functions of human body. Rapidly developed multi-omics and systems biology are impacting on treatment of pituitary adenomas and changing the paradigms from the traditional single-factor strategy to a multi-parameter systematic strategy. A series of molecular alterations at different levels of genes (genome), RNAs (transcriptome), proteins (proteome), peptides (peptidome), metabolites (metabolome), and imaging characteristics (radiome) that resulted from exogenous and endogenous carcinogens are involved in pituitary tumorigenesis and mutually associate and function in a molecular network system, thus determines the difficulty in the use of a single molecule as biomarker to clarify its molecular mechanisms, and to predict, prevent, diagnose, and treat a pituitary adenoma. Of them, molecular network study plays central roles. A key molecule-panel biomarker that is derived from molecular network is necessary for accurately clinical practice of a pituitary adenoma. The modern multi-omics, computation biology, and systems biology technologies lead to the possibility in recognizing really reliable molecular-panel biomarker for research and clinical practice in pituitary adenomas.

Medicine --- Endocrinology --- pituitary adenoma --- signaling pathway --- molecular network --- multi-omics --- personalized medicine --- precision medicine --- therapeutic target --- molecule-panel biomarker

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

This book gathers a collection of review articles aiming to provide an update of the current knowledge on PD pathogenesis. It notably includes an overview of several key cellular dysfunctions underlying the etiology of Parkinson’s disease, including ER stress, mitophagy and alpha-synuclein-linked pathology.

Medicine --- Neurosciences --- Parkinson’s disease --- unfolded protein response --- reticulum endoplasmic --- genetics --- alpha-synuclein --- prion-like spreading --- cell-to-cell transfer --- neurodegeneration --- mitochondrial dysfunction --- PINK1 --- neurons --- astrocytes --- microglia --- α-synuclein --- exocytosis --- lipids --- membranes --- Parkinson disease --- SNARE complex --- synapse --- vesicle fusion --- therapeutic target --- protein quality control --- mitochondrial quality control --- ubiquitin --- alpha-syn --- mitophagy --- Parkin --- mito-Keima --- mito-QC --- mito-SRAI

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

This book gathers a collection of review articles aiming to provide an update of the current knowledge on PD pathogenesis. It notably includes an overview of several key cellular dysfunctions underlying the etiology of Parkinson’s disease, including ER stress, mitophagy and alpha-synuclein-linked pathology.

Parkinson’s disease --- unfolded protein response --- reticulum endoplasmic --- genetics --- alpha-synuclein --- prion-like spreading --- cell-to-cell transfer --- neurodegeneration --- mitochondrial dysfunction --- PINK1 --- neurons --- astrocytes --- microglia --- α-synuclein --- exocytosis --- lipids --- membranes --- Parkinson disease --- SNARE complex --- synapse --- vesicle fusion --- therapeutic target --- protein quality control --- mitochondrial quality control --- ubiquitin --- alpha-syn --- mitophagy --- Parkin --- mito-Keima --- mito-QC --- mito-SRAI