Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

This volume explores techniques that are currently used to understand solid target-specific models in computational toxicology. The chapters are divided into four sections and discuss topics such as molecular descriptors, QSAR and read-across; molecular and data modeling techniques to comply both with scientific and regulatory sides; computational toxicology in drug discovery; and strategies on how to predict various human-health toxicology endpoints. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the methods and software tools used, step-by-step, readily reproducible computational protocols, and tips on troubleshooting and avoiding known pitfalls. Comprehensive and cutting-edge, Computational Toxicology: Methods and Protocols is a valuable resource for researchers who are interested in learning more about this expanding field.

Toxicology. --- Pharmacology/Toxicology. --- Chemicals --- Medicine --- Pharmacology --- Poisoning --- Poisons --- Toxicology --- Toxicologia --- Models matemàtics --- Models (Matemàtica) --- Models experimentals --- Models teòrics --- Mètodes de simulació --- Anàlisi de sistemes --- Mètode de Montecarlo --- Modelització multiescala --- Models economètrics --- Models lineals (Estadística) --- Models multinivell (Estadística) --- Models no lineals (Estadística) --- Programació (Ordinadors) --- Simulació per ordinador --- Teoria de màquines --- Models biològics --- Farmacologia --- Dermatotoxicologia --- Immunotoxicologia --- Neurotoxicologia --- Toxicologia ambiental --- Toxicologia experimental --- Toxicologia industrial --- Toxicologia genètica --- Toxicologia pediàtrica --- Emmetzinament --- Intoxicació --- Verins

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

This book explores well-established and emerging conjugation strategies that are relevant for proteins used in the field of precision medicine, focusing on techniques that are suitable for antibodies, antibody-fragments such as Fabs, scFvs, or nanobodies, scaffold proteins such as FN3 or DARPin, peptides, or model proteins. Although centered on the development of bioconjugates rather than their application, most protocols also show the conjugation of the targeting vehicle to a diagnostic or therapeutic entity, with the end-product most often being an antibody-drug conjugate, an optical probe, a nanomedicine, or a radiopharmaceutical. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Bioconjugation: Methods and Protocols is an ideal guide for researchers looking toward precision medicine in order to expand the vital field of drug discovery.

Monoclonal antibodies. --- Biochemistry. --- Toxicology. --- Antibodies. --- Protein Science. --- Pharmacology/Toxicology. --- Chemicals --- Medicine --- Pharmacology --- Poisoning --- Poisons --- Biological chemistry --- Chemical composition of organisms --- Organisms --- Physiological chemistry --- Biology --- Chemistry --- Medical sciences --- Antibodies, Monoclonal --- Monoclonal immunoglobulins --- Immunoglobulins --- Molecular cloning --- Toxicology --- Composition --- Anticossos monoclonals --- Toxicologia --- Manuals de laboratori --- Tècniques de laboratori --- Farmacologia --- Dermatotoxicologia --- Immunotoxicologia --- Neurotoxicologia --- Toxicologia ambiental --- Toxicologia experimental --- Toxicologia industrial --- Toxicologia genètica --- Toxicologia pediàtrica --- Emmetzinament --- Intoxicació --- Verins --- Immunoglobulines monoclonals --- Clonatge molecular --- Immunoglobulines --- Rituximab

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

Apoptosis, or programmed cell death, is a widespread cellular process that regulates numerous important biological events ranging from the metamorphosis of the tadpole tail to the elimination of surplus brain cells in the formation of proper synaptic connections. In Apoptosis Methods in Pharmacology and Toxicology: Approaches to Measurement and Quantification, Dr. Myrtle A. Davis has assembled a panel of cutting-edge scientists to describe their best methods for detecting, illuminating, and quantifying apoptotic mechanisms in a way that is useful in toxicology and pharmacology research. These state-of-the-art techniques include flow cytometric, fluorometric, and laser scanning methods for quantifying and characterizing apoptosis, as well as protocols for the use of DNA microarray technology, high-throughput screens, and ELISA. Immunocytochemical methods for measuring biochemical and molecular endpoints in tissue sections will be highly useful for those carrying out studies in whole animal models as opposed to cell culture systems. Presented by authors well-versed in the technical problems and challenges in analyzing apoptosis, each method explicates its successful use, describes its limitations, and shows how it may be applied in large-scale screening operations. Concise and eminently practical, Apoptosis Methods in Pharmacology and Toxicology: Approaches to Measurement and Quantification offers pharmacologists, toxicologists, pathologists, and many other biomedical scientists today's gold standard reference source for methods that definitively identify and accurately quantify apoptosis.

Toxicology. --- Pharmacology/Toxicology. --- Chemicals --- Medicine --- Pharmacology --- Poisoning --- Poisons --- Toxicology --- Apoptosi --- Farmacologia --- Toxicologia --- Manuals de laboratori --- Tècniques de laboratori --- Dermatotoxicologia --- Immunotoxicologia --- Neurotoxicologia --- Toxicologia ambiental --- Toxicologia experimental --- Toxicologia industrial --- Toxicologia genètica --- Toxicologia pediàtrica --- Emmetzinament --- Intoxicació --- Verins --- Medicina --- Biofarmàcia --- Biotransformació (Metabolisme) --- Dermofarmacologia --- Desenvolupament de medicaments --- Estabilitat dels medicaments --- Farmacocinètica --- Farmacogenètica --- Farmacologia cardiovascular --- Farmacologia clínica --- Farmacologia dental --- Farmacologia geriàtrica --- Farmacologia molecular --- Farmacologia obstètrica --- Farmacologia ocular --- Farmacologia pediàtrica --- Farmacologia respiratòria --- Farmacologia renal --- Farmacologia veterinària --- Fotofarmacologia --- Immunofarmacologia --- Isòtops radioactius en farmacologia --- Neurofarmacologia --- Psicofarmacologia --- Química farmacèutica --- Radiofàrmacs --- Resistència als medicaments --- Medicaments --- Quimioteràpia --- Mort cel·lular

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

The fifth edition of the best-selling Principles in Forensic Toxicology continues in the tradition of excellence in academic publishing. With over 10 years of classroom-tested and continually updated content, the new edition contains significant updates and 7 new chapters on new topics including drug-facilitated crimes, derivatization, quantitation, measurement uncertainty/traceability, statistics, oral fluid testing, and drugs in embalmed specimens. Part One covers the major sub-disciplines of forensic toxicology in addition to pharmacological concepts. Part Two addresses specimen preparation, laboratory testing and instrumental analysis, while Part Three discusses common analytes including cocaine, opioids, alcohol, and marijuana. Adopted for courses in many of the top universities for forensic science and used by respected medical examiner’s offices and crime laboratories worldwide, Principles of Forensic Toxicology prepares the next generation of forensic toxicologists and continues to be an important reference in professional practice.

Pharmacology. --- Forensic science. --- Forensic medicine. --- Pharmacology/Toxicology. --- Forensic Science. --- Forensic Medicine. --- Criminalistics --- Forensic science --- Science --- Criminal investigation --- Drug effects --- Medical pharmacology --- Medical sciences --- Chemicals --- Chemotherapy --- Drugs --- Pharmacy --- Forensic medicine --- Injuries (Law) --- Jurisprudence, Medical --- Legal medicine --- Forensic sciences --- Medicine --- Medical laws and legislation --- Physiological effect --- Forensic toxicology. --- Medicolegal toxicology --- Toxicology --- Chemistry, Forensic --- Medical jurisprudence --- Jurisprudence --- Toxicologia --- Medicina legal --- Jurisprudència mèdica --- Lesions (Dret) --- Medicina forense --- Prova (Dret) --- Autòpsia --- Entomologia forense --- Genètica forense --- Odontologia legal --- Osteologia forense --- Psicologia forense --- Psiquiatria forense --- Simulació (Ciències de la salut) --- Veterinària legal --- Antropologia forense --- Farmacologia --- Dermatotoxicologia --- Immunotoxicologia --- Neurotoxicologia --- Toxicologia ambiental --- Toxicologia experimental --- Toxicologia industrial --- Toxicologia genètica --- Toxicologia pediàtrica --- Emmetzinament --- Intoxicació --- Verins

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

The range of nanomaterial applications has expanded recently from catalysis, electronics, and filtration to therapeutics, diagnostics, agriculture, and food because of the unique properties and potentials of different nanoparticles and nanomaterials. Research shows that these exquisite particles can interact with an organism at the cellular, physiological, biochemical, and molecular levels. Our knowledge, however, of how they affect these changes, selectively or generally, in diverse organisms or ecosystems is very limited and far from satisfactory. Data indicate that the biological function largely depends on the shape, size, and surface characteristics of the nanoparticles used along with life cycle stages of an organism. This book focuses on the body of work carried out by distinguished investigators using diverse nanomaterials in both plant and animal species. It includes specific case studies as well as general reviews highlighting aspects of multilayered interactions. This volume provides a comprehensive resource for academic scholars, as well as for researchers in the concerned industries and policy makers.

Nanostructured materials --- Toxicology. --- Nanomaterials --- Nanometer materials --- Nanophase materials --- Nanostructure controlled materials --- Nanostructure materials --- Ultra-fine microstructure materials --- Microstructure --- Nanotechnology --- Materials nanoestructurats --- Toxicologia --- Farmacologia --- Dermatotoxicologia --- Immunotoxicologia --- Neurotoxicologia --- Toxicologia ambiental --- Toxicologia experimental --- Toxicologia industrial --- Toxicologia genètica --- Toxicologia pediàtrica --- Emmetzinament --- Intoxicació --- Verins --- Aliatges nanocristal·lines --- Materials de microestructura ultrafina --- Materials de nanoestructura controlada --- Materials de nanofase --- Materials de nanòmetre --- Materials nanocristal·lins --- Materials nanocompostos --- Metalls nanocristal·lins --- Microestructura --- Nanotecnologia --- Nanopartícules --- Nanotubs --- Nanotoxicologia --- Plants --- Nanotechnology. --- Botanical chemistry. --- Plant biotechnology. --- Biochemistry. --- Plant Development. --- Plant Biochemistry. --- Plant Biotechnology. --- Chemical Biology. --- Plant Evolution. --- Development. --- Evolution. --- Plant evolution --- Evolution (Biology) --- Biological chemistry --- Chemical composition of organisms --- Organisms --- Physiological chemistry --- Biology --- Chemistry --- Medical sciences --- Crop biotechnology --- Crops --- Agricultural biotechnology --- Phytochemistry --- Plant biochemistry --- Plant chemistry --- Biochemistry --- Botany --- Phytochemicals --- Plant biochemical genetics --- Molecular technology --- Nanoscale technology --- High technology --- Development of plants --- Plant development --- Developmental biology --- Growth (Plants) --- Phylogeny --- Composition --- Biotechnology --- Ontogeny