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Genetic variations may change the structure and function of individual proteins as well as affect their interactions with other proteins and thereby impact metabolic processes dependent on protein-protein interactions. For example, cytochrome P450 proteins, which metabolize a vast array of drugs, steroids and other xenobiotics, are dependent on interactions with redox and allosteric partner proteins for their localization, stability, (catalytic) function and metabolic diversity (reactions). Genetic variations may impact such interactions by changing the splicing and/or amino acid sequence which in turn may impact protein topology, localization, post translational modifications and three dimensional structure. More generally, research on single gene defects and their role in disease, as well as recent large scale sequencing studies suggest that a large number of genetic variations may contribute to disease not only by affecting gene function or expression but also by modulating complex protein interaction networks. The aim of this research topic is to bring together researchers working in the area of drug, steroid and xenobiotic metabolism who are studying protein-protein interactions, to describe their recent advances in the field. We are aiming for a comprehensive analysis of the subject from different approaches including genetics, proteomics, transcriptomics, structural biology, biochemistry and pharmacology. Of particular interest are papers dealing with translational research describing the role of novel genetic variations altering protein-protein interaction. Authors may submit original articles, reviews and opinion or hypothesis papers dealing with the role of protein-protein interactions in health and disease. Potential topics include, but are not limited to: • Role of protein-protein interactions in xenobiotic metabolism by cytochrome P450s and other drug metabolism enzymes. • Role of classical and novel interaction partners for cytochrome P450-dependent metabolism which may include interactions with redox partners, interactions with other P450 enzymes to form P450 dimers/multimers, P450-UGT interactions and proteins involved in posttranslational modification of P450s. • Effect of genetic variations (mutations and polymorphisms) on metabolism affected by protein-protein interactions. • Structural implications of mutations and polymorphisms on protein-protein interactions. • Functional characterization of protein-protein interactions. • Analysis of protein-protein interaction networks in health and disease. • Regulatory mechanisms governing metabolic processes based on protein-protein interactions. • Experimental approaches for identification of new protein-protein interactions including changes caused by mutations and polymorphisms.

POR --- Pharmacogenetics --- UGT --- Biocatalysis --- UDP-glucuronosyltransferase --- Cytochrome P450 --- Drug metabolism --- Membrane-associated progesterone receptor --- PXR --- Steroids

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Genetic variations may change the structure and function of individual proteins as well as affect their interactions with other proteins and thereby impact metabolic processes dependent on protein-protein interactions. For example, cytochrome P450 proteins, which metabolize a vast array of drugs, steroids and other xenobiotics, are dependent on interactions with redox and allosteric partner proteins for their localization, stability, (catalytic) function and metabolic diversity (reactions). Genetic variations may impact such interactions by changing the splicing and/or amino acid sequence which in turn may impact protein topology, localization, post translational modifications and three dimensional structure. More generally, research on single gene defects and their role in disease, as well as recent large scale sequencing studies suggest that a large number of genetic variations may contribute to disease not only by affecting gene function or expression but also by modulating complex protein interaction networks. The aim of this research topic is to bring together researchers working in the area of drug, steroid and xenobiotic metabolism who are studying protein-protein interactions, to describe their recent advances in the field. We are aiming for a comprehensive analysis of the subject from different approaches including genetics, proteomics, transcriptomics, structural biology, biochemistry and pharmacology. Of particular interest are papers dealing with translational research describing the role of novel genetic variations altering protein-protein interaction. Authors may submit original articles, reviews and opinion or hypothesis papers dealing with the role of protein-protein interactions in health and disease. Potential topics include, but are not limited to: • Role of protein-protein interactions in xenobiotic metabolism by cytochrome P450s and other drug metabolism enzymes. • Role of classical and novel interaction partners for cytochrome P450-dependent metabolism which may include interactions with redox partners, interactions with other P450 enzymes to form P450 dimers/multimers, P450-UGT interactions and proteins involved in posttranslational modification of P450s. • Effect of genetic variations (mutations and polymorphisms) on metabolism affected by protein-protein interactions. • Structural implications of mutations and polymorphisms on protein-protein interactions. • Functional characterization of protein-protein interactions. • Analysis of protein-protein interaction networks in health and disease. • Regulatory mechanisms governing metabolic processes based on protein-protein interactions. • Experimental approaches for identification of new protein-protein interactions including changes caused by mutations and polymorphisms.

POR --- Pharmacogenetics --- UGT --- Biocatalysis --- UDP-glucuronosyltransferase --- Cytochrome P450 --- Drug metabolism --- Membrane-associated progesterone receptor --- PXR --- Steroids

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Genetic variations may change the structure and function of individual proteins as well as affect their interactions with other proteins and thereby impact metabolic processes dependent on protein-protein interactions. For example, cytochrome P450 proteins, which metabolize a vast array of drugs, steroids and other xenobiotics, are dependent on interactions with redox and allosteric partner proteins for their localization, stability, (catalytic) function and metabolic diversity (reactions). Genetic variations may impact such interactions by changing the splicing and/or amino acid sequence which in turn may impact protein topology, localization, post translational modifications and three dimensional structure. More generally, research on single gene defects and their role in disease, as well as recent large scale sequencing studies suggest that a large number of genetic variations may contribute to disease not only by affecting gene function or expression but also by modulating complex protein interaction networks.The aim of this research topic is to bring together researchers working in the area of drug, steroid and xenobiotic metabolism who are studying protein-protein interactions, to describe their recent advances in the field. We are aiming for a comprehensive analysis of the subject from different approaches including genetics, proteomics, transcriptomics, structural biology, biochemistry and pharmacology. Of particular interest are papers dealing with translational research describing the role of novel genetic variations altering protein-protein interaction. Authors may submit original articles, reviews and opinion or hypothesis papers dealing with the role of protein-protein interactions in health and disease.

POR --- Pharmacogenetics --- UGT --- Biocatalysis --- UDP-glucuronosyltransferase --- Cytochrome P450 --- Drug metabolism --- Membrane-associated progesterone receptor --- PXR --- Steroids

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Tensions in South African universities have traditionally centred around equity (particularly access and affordability), historical legacies (such as apartheid and colonialism), and the shape and structure of the higher education system. What has not received sufficient attention, is the contribution of the university to place-based development. This volume is the first in South Africa to engage seriously with the place-based developmental role of universities. In the international literature and policy there has been an increasing integration of the university with place-based development, especially in cities. This volume weighs in on the debate by drawing attention to the place-based roles and agency of South African universities in their local towns and cities. It acknowledges that universities were given specific development roles in regions, homelands and towns under apartheid, and comments on why sub-national, place-based development has not been a key theme in post-apartheid, higher education planning. Given the developmental crisis in the country, universities could be expected to play a more constructive and meaningful role in the development of their own precincts, cities and regions. But what should that role be? Is there evidence that this is already occurring in South Africa, despite the lack of a national policy framework? What plans and programmes are in place, and what is needed to expand the development agency of universities at the local level? Who and what might be involved? Where should the focus lie, and who might benefit most, and why? Is there a need perhaps to approach the challenges of college towns, secondary cities and metropolitan centers differently? This book poses some of these questions as it considers the experiences of a number of South African universities, including Wits, Pretoria, Nelson Mandela University and especially Fort Hare as one of its post-centenary challenges.

Education, Higher --- Higher Education South Africa (Organization) --- University Development Programme (South Africa) --- HESA --- South African Universities' Vice Chancellors' Association --- Universities and Technikons Advisory Council (South Africa). --- UDP --- Community development --- Community and college --- College and community --- Town and gown --- University and community --- Universities and colleges --- University towns --- Education --- South Africa

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Message logging is the tool of choice to stay informed about the health of a machine or application. These messages, called logs, are used for various purposes, including system management, performance optimization, investigation of suspicious activities, and more generally analysis and debugging. Operations that demand a level of reliability at least equivalent to the emphasis placed on them during their use. However, the syslog protocol was originally designed to work exclusively over UDP. Traditional applications, which have not benefited from the a postorio additions such as TCP, are forced to communicate over a network that is not suitable for them (corrupted or lost messages, reordering, or unreachable server) and over which they have no control. The objective of this work is to develop a resilient syslog relay that will operate downstream of applications, collect their syslog messages and send them to a central syslog server. Several mechanisms such as the use of the TCP protocol and the retention of messages in case of connection loss guarantee reliability. Topics related to message ordering and strategies in case of an overload are also discussed and several approaches are presented to either mitigate or regulate their impact. The implementation, in the form of a prototype, is deployed inside a router running the Cisco IOx environment and features the modern syslog message engine, rsyslog. The model is evaluated on the basis of its functionality and performance in a test environment with network quality such as 3G cellular and EDGE. Several configurations are proposed depending on the type of usage involved. Although the solution does not cover all possible and imaginable problems, such as router outages, the evaluations demonstrate the efficiency and scalability of the proposed solution, which can for example easily handle several tens of thousands of messages per second with a very low resource footprint.

docker --- cisco --- iox --- syslog --- log --- rsyslog --- aarch64 --- linux --- event --- relay --- reliable --- store and forward --- kibana --- elasticsearch --- message generator --- python --- router --- cellular --- network --- TCP --- UDP --- TLS --- configuration --- ioxclient --- chronological order --- timestamp --- 3G --- EDGE --- performance --- testbed --- wanem --- downtime, --- recover --- permanent storage --- open source --- central server --- server --- low footprint --- Ingénierie, informatique & technologie > Sciences informatiques