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Continuous pharmaceutical manufacturing is currently receiving much interest from industry and regulatory authorities, with the joint aim of allowing rapid access of novel therapeutics and existing medications to the public, without compromising high quality. Research groups from different academic institutions have significantly contributed to this field with an immense amount of published research addressing a variety of topics related to continuous processing. The book is structured to have individual chapters on the different continuous unit operations involved in drug substance and drug product manufacturing. A wide spectrum of topics are covered, including basic principles of continuous manufacturing, applications of continuous flow chemistry in drug synthesis, continuous crystallization, continuous drying, feeders and blenders, roll compaction and continuous wet granulation.The underlying theme for each of these chapters is to present to the reader the recent advances in modeling, experimental investigations and equipment design as they pertain to each individual unit operation. The book also includes chapters on quality by design (QbD) and process analytical technology (PAT) for continuous processing, process control strategies including new concepts of quality-by-control (QbC), real-time process management and plant optimization, business and supply chain considerations related to continuous manufacturing as well as safety guidelines related to continuous chemistry. A separate chapter is dedicated to discussing regulatory aspects of continuous manufacturing, with description of current regulatory environment quality/GMP aspects, as well as regulatory gaps and challenges. Our aim from publishing this book is to make it a valuable reference for readers interested in this topic, with a desire to gain a fundamental understanding of engineering principles and mechanistic studies utilized in understanding and developing continuous processes. In addition, our advanced readers and practitioners in this field will find that the technical content of Continuous Pharmaceutical Processing is at the forefront of recent technological advances, with coverage of future prospects and challenges for this technology. .

Pharmaceutical industry --- Management. --- Pharmaceutical technology. --- Pharmaceutical Sciences/Technology. --- Pharmaceutical laboratory techniques --- Pharmaceutical laboratory technology --- Technology, Pharmaceutical --- Technology --- Indústria farmacèutica --- Tecnologia farmacèutica --- Farmàcia galènica --- Tècnica farmacèutica --- Tècniques farmacèutiques --- Tecnologies farmacèutiques --- Anàlisi de medicaments --- Biotecnologia farmacèutica --- Dispositius d'administració de medicaments --- Síntesi de fàrmacs --- Sistemes d'alliberament de medicaments --- Farmàcia --- Empreses farmacèutiques --- Indústria química --- Farmàcies --- Utilització de medicaments --- Indústria cosmètica

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Medicine. --- Toxicology. --- Gastroenterology. --- Internal medicine --- Digestive organs --- Chemicals --- Medicine --- Pharmacology --- Poisoning --- Poisons --- Health Workforce --- Diseases --- Toxicology --- Quimioteràpia --- Gastroenterologia --- Medicina interna --- Aparell digestiu --- Gastroenterologia pediàtrica --- Proctologia --- Tracte gastrointestinal --- Hepatologia --- Malalties de l'aparell digestiu --- Farmacoteràpia --- Immunoquimioteràpia --- Terapèutica medicamentosa --- Terapèutica per agents químics (Medicina) --- Tractament amb medicaments --- Tractament per agents químics (Medicina) --- Us terapèutic dels medicaments --- Terapèutica --- Administració de medicaments --- Antibiòtics --- Diürètics --- Fotoquimioteràpia --- Pirogens --- Psicofarmacologia --- Prescripció de medicaments --- Quimioteràpia del càncer --- Utilització de medicaments --- Farmacologia --- Medicaments

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Chemistry --- Pharmaceutical industry. --- Philosophy. --- Drug industry --- Drug trade --- Medicine industry --- Medicines industry --- Prescription medicine industry --- Chemical industry --- Química farmacèutica --- Indústria farmacèutica --- Optimització matemàtica --- Mètodes de simulació --- Jocs d'estratègia (Matemàtica) --- Optimització combinatòria --- Programació dinàmica --- Programació (Matemàtica) --- Anàlisi de sistemes --- Empreses farmacèutiques --- Indústria química --- Farmàcies --- Utilització de medicaments --- Indústria cosmètica --- Farmacoquímica --- Química dels medicaments --- Química mèdica --- Química patològica --- Química terapèutica --- Farmàcia --- Farmacologia --- Química --- Matèria mèdica --- Medicaments --- Química combinatòria

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This first volume of an exciting new book series offers a comprehensive and logically organized introduction to clinical pharmacy as applied to renal medicine. The volume opens with a review of renal pharmacokinetics: absorption; distribution; metabolism; and elimination, as well as drug dosing in renal impairment, and important knowledge specific to aging and renal impairment. Acute kidney injury receives extensive attention, including pre-renal, intra-renal, and post-renal injuries. The book also outlines the role of clinical pharmacy in chronic kidney disease and end stage renal failure. Additional chapters provide detailed information on the methods and pharmacokinetics of renal dialysis, and the epidemiology and management of drug-induced nephrotoxicity. The Advanced Clinical Pharmacy series provides a review of core pharmaceutical concepts, a foundation for optimizing pharmacotherapy, and an introduction to advanced clinical practice. The editors and contributors are international experts who distill the core knowledge of each specialty. The books offer real-world insights to benefit both new practitioners, and experienced pharmacists exploring new areas of clinical pharmacy.

Pharmacy. --- Pharmacotherapy. --- Nephrology. --- Internal medicine --- Kidneys --- Drug therapy --- Pharmacotherapy --- Therapeutics --- Drugs --- Pharmacology --- Chemistry --- Medicine --- Materia medica --- Clinical pharmacology. --- Diseases --- Treatment. --- Clinical medicine --- Quimioteràpia --- Malalties del ronyó --- Malalties dels ronyons --- Malalties renals --- Nefropaties --- Malalties de l'aparell urinari --- Càlculs renals --- Hipertensió renal --- Glomerulonefritis --- Insuficiència renal --- Nefropaties diabètiques --- Osteodistròfia renal --- Proteïnúria --- Síndrome nefròtica --- Nefrologia --- Ronyó --- Farmacoteràpia --- Immunoquimioteràpia --- Terapèutica medicamentosa --- Terapèutica per agents químics (Medicina) --- Tractament amb medicaments --- Tractament per agents químics (Medicina) --- Us terapèutic dels medicaments --- Terapèutica --- Administració de medicaments --- Antibiòtics --- Diürètics --- Fotoquimioteràpia --- Pirogens --- Psicofarmacologia --- Prescripció de medicaments --- Quimioteràpia del càncer --- Utilització de medicaments --- Farmacologia --- Medicaments

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Renal pharmacology. --- Drugs --- Dosage. --- Metabolism. --- Kidneys --- Kidneys, Effect of drugs on --- Pharmacology --- Drug metabolism --- Pharmacokinetics --- Dosage of drugs --- Dosiology --- Microdosage of drugs --- Posology --- Drug effects --- Effect of drugs on --- Microdosage --- Administration --- Quimioteràpia --- Posologia --- Metabolisme dels medicaments --- Farmacoteràpia --- Immunoquimioteràpia --- Terapèutica medicamentosa --- Terapèutica per agents químics (Medicina) --- Tractament amb medicaments --- Tractament per agents químics (Medicina) --- Us terapèutic dels medicaments --- Terapèutica --- Administració de medicaments --- Antibiòtics --- Diürètics --- Fotoquimioteràpia --- Pirogens --- Psicofarmacologia --- Prescripció de medicaments --- Quimioteràpia del càncer --- Utilització de medicaments --- Farmacologia --- Medicaments --- Metabolisme de fàrmacs --- Farmacocinètica --- Dosimetria --- Dosificació de medicaments --- Aritmètica farmacèutica --- Prospectes de medicaments