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The objective of the current review was to perform a systematic review of the beneficial and harmful effects of rVWF (650 IU VWF ristocetin cofactor [VWF:RCo]/vial and 1,300 IU VWF:RCo/vial) for the treatment and control of bleeding episodes in adults diagnosed with VWD, and for the perioperative management of bleeding in adults diagnosed with VWD.

Von Willebrand factor. --- Diseases --- Treatment.

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Factor VIII --- immunology --- VON WILLEBRAND FACTOR, analysis

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Hemophilia A. --- Hemophilia --- Hemophilia. --- Von Willebrand disease --- Von Willebrand disease. --- Von Willebrand factor --- Von Willebrand factor.

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Pathological haematology --- Blood platelets --- Megakaryocytes --- Von Willebrand factor --- Barnhart, Marion I --- Blood Platelets --- Factor VIII --- Von Willebrand Factor --- physiology --- physiopathology --- Blood platelets - Congresses --- Megakaryocytes - Congresses --- Von Willebrand factor - Congresses --- Factor 8/von Willebrand factor --- Blood platelet physiology --- Platelet-vessel wall interaction --- Megakaryocytopoiesis --- Barnhart, Marion I - Congresses

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von Willebrand Factor --- von Willebrand Diseases --- Genetics, Population --- Genes, Recessive --- genetics --- genetics