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This second edition of the Special Issue “Marine Bioactive Peptides: Structure, Function, and Therapeutic Potential - II” published papers on up-to-date information regarding isolation, structural elucidation, functional characterization, and therapeutic potential evaluation of peptides isolated from marine organisms. Chemical synthesis and biotechnological production of marine peptides and their mimetics will also be a focus of this Special Issue. In addition, this Special Issue will publish new results arising from a peptidomic approach. 24 Papers were accepted and included in the first issue, which we published as a Special Issue book (https://www.mdpi.com/books/pdfview/book/1742). Following the success of the first Special Issue, as Guest Editor, I invite researchers in the field to contribute to the second edition entitled " Marine Bioactive Peptides: Structure, Function, and Therapeutic Potential - II] ".

Medicine --- Spanish mackerel (Scomberomorous niphonius) --- muscle --- peptide --- antioxidant activity --- stability --- biological activity --- chemistry --- marine derived fungi --- peptides --- biotransformation --- laxaphycin --- autophagy --- apoptosis --- cyanobacteria --- bioactive peptides --- marine --- secondary structure --- proline --- mechanism of activity --- marine waste --- antimicrobial peptide --- polychaeta --- innate immunity --- BRICHOS domain --- recombinant peptide --- β-hairpin structure --- nuclear magnetic resonance (NMR) --- arenicin --- complement system --- complement regulation --- jellyfish --- Rhopilema esculentum --- Sanderia malayensis --- proteome --- venom --- toxin --- hydrolysate --- fish protein --- ageing --- physical function --- dietary assessment --- seafood intake --- healthy ageing --- marine organism --- anticancer medicine --- small peptide --- liner peptide --- cyclic peptide --- marine peptide --- dolastatin 10 --- antitumor --- lead exploration --- n/a

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This Special Issue Book, “Marine Bioactive Peptides: Structure, Function, andTherapeutic Potential"" includes up-to-date information regarding bioactivepeptides isolated from marine organisms. Marine peptides have been found invarious phyla, and their numbers have grown in recent years. These peptidesare diverse in structure and possess broad-spectrum activities that have greatpotential for medical applications. Various marine peptides are evolutionaryancient molecular factors of innate immunity that play a key role in host defense.A plethora of biological activities, including antibacterial, antifungal, antiviral,anticancer, anticoagulant, endotoxin-binding, immune-modulating, etc., makemarine peptides an attractive molecular basis for drug design. This Special IssueBook presents new results in the isolation, structural elucidation, functionalcharacterization, and therapeutic potential evaluation of peptides found inmarine organisms. Chemical synthesis and biotechnological production of marinepeptides and their mimetics is also a focus of this Special Issue Book.

cone snail --- tilapia --- n/a --- animal models --- BRICHOS domain --- recombinant peptide --- calcium absorption --- plastein reaction --- antioxidant activity --- endothelial dysfunction --- C3a --- lung cancer --- invertebrate immunity --- identification --- zinc bioavailability --- NA-inhibitory peptide --- nuclear magnetic resonance (NMR) --- review --- ACE-inhibitory activity --- intestinal absorption --- hairtail (Trichiurus japonicas) --- DU-145 cells --- peptide --- crustacean --- venom duct --- Kalloconus --- drug design --- molecular symmetry --- arenicin --- ?-helix --- APETx2 --- conotoxins --- functional diversity --- docking --- conotoxin --- neuraminidase --- angiotensin II --- polychaeta --- influenza virus --- phylogeny --- gene expression --- host defense peptide --- Perinereis aibuhitensis --- anti-diabetic activity --- conopeptides --- SHRs --- Chlorella pyrenoidosa protein hydrolysate (CPPH) --- metastasis --- Caco-2 cell monolayer --- Nrf2 --- caco-2 cells --- HUVEC --- PYP15 --- sea cucumber --- decapeptide --- cytotoxic --- arenicin-1 --- marine peptides --- cell proliferation --- Conus --- Conus ateralbus --- self-production of hydrogen peroxide --- antimicrobial activity --- molecular dynamics --- machine learning --- tachyplesins --- ion channels --- gut microbiota --- Anthopleura anjunae oligopeptide --- signaling pathways --- half-fin anchovy hydrolysates --- NF-?B --- Chlorella pyrenoidosa protein hydrolysate-calcium chelate (CPPH-Ca) --- antihypertensive effect --- QAGLSPVR --- antimicrobial peptides --- vasculogenic mimicry --- antibacterial --- ?-hairpin --- innate immunity --- transcriptome sequencing --- HIF-1? --- Gracilariopsis lemaneiformis --- function --- ACE-inhibitory peptide --- complement --- peptide-zinc complex --- structure-activity relationship --- multi-functional peptides --- cod skin --- adsorption --- Maillard reaction products --- molecular docking --- antibacterial peptide --- PI3K/AKT/mTOR signaling pathway --- Arenicola marina --- structure–activity relationship --- antimicrobial peptide --- Rana-box --- acid-sensing ion channel --- Neptunea arthritica cumingii --- apoptosis --- membrane damage --- proteolytic system --- toxin --- polyphemusins --- computational studies --- muscle --- oyster zinc-binding peptide --- abalone --- pain relief --- transport routes --- cytotoxicity --- dexamethasone --- cell death --- host?microbe relationship --- anti-LPS factor --- MMPs --- protein synthesis --- structure --- Pyropia yezoensis peptide --- cone snails --- chemical synthesis --- prostate cancer --- Ugr 9-1 --- myotube atrophy