Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

Chemical Linkers in Antibody-Drug Conjugates aims to shine a detailed light on the various key attributes of chemical linkers in ADCs, for drug-to-antibody ratio, for stability, for release mechanism of payload, for pharmacokinetics, for stability determination, and for efficacy and safety.

Antibody-drug conjugates.

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

This authoritative volume provides a holistic picture of antibody-drug conjugates (ADCs). Fourteen comprehensive chapters are divided into six sections including an introduction to ADCs, the ADC construct, development issues, landscape, IP and pharmacoeconomics, case studies, and the future of the field. The book examines everything from the selection of the antibody, the drug, and the linker to a discussion of developmental issues such as formulations, bio-analysis, pharmacokinetic-pharmacodynamic relationships, and toxicological and regulatory challenges. It also explores pharmacoecomonics and intellectual properties, including recently issued patents and the cost analysis of drug therapy. Case studies are presented for the three ADCs that have received FDA approval: gemtuzumab ozogamicin (Mylotarg®), Brentuximab vedotin (Adcetris®), and ado-trastuzumab emtansine (Kadcyla®), as well as an ADC in late-stage clinical trials, glembatumumab vedotin (CDX-011). Finally, the volume presents a perspective by the editors on the future directions of ADC development and clinical applications. Antibody-Drug Conjugates is a practical and systematic resource for scientists, professors, and students interested in expanding their knowledge of cutting-edge research in this exciting field.

Biomedicine. --- Pharmaceutical Sciences/Technology. --- Medicine. --- Pharmaceutical technology. --- Médecine --- Techniques pharmaceutiques --- Antibody-drug conjugates. --- Antibody-toxin conjugates. --- Drugs -- Research. --- Health & Biological Sciences --- Pharmacy, Therapeutics, & Pharmacology --- Conjugates, Antibody-toxin --- Immunoconjugates --- Immunoglobulin-toxin conjugates --- Immunotoxins --- Toxin-antibody conjugates --- Toxin-immunoglobulin conjugates --- Conjugates, Antibody-drug --- Drug-antibody conjugates --- Drug immunoconjugates --- Drug-immunoglobulin conjugates --- Immunoconjugates, Drug --- Immunoglobulin-drug conjugates --- Bioconjugates --- Immunopharmacology --- Immunotoxicology --- Toxins --- Drugs --- Dosage forms --- Pharmaceutical laboratory techniques --- Pharmaceutical laboratory technology --- Technology, Pharmaceutical --- Technology

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

Approaches to the Purification, Analysis and Characterization of Antibody-Based Therapeutics provides the interested and informed reader with an overview of current approaches, strategies and considerations relating to the purification, analytics and characterization of therapeutic antibodies and related molecules. While there are obviously other books published in and around this subject area, they seem to be either older (c.a. year 2000 publication date) or are more limited in scope. The book will include an extensive bibliography of the published literature in the respective areas covered. It is not, however, intended to be a how-to methods book.

Antibody-drug conjugates. --- Immunoglobulins. --- Antibodies --- Immune globulins --- Immune serum globulin --- Blood proteins --- Globulins --- Plasma cells --- Antibody diversity --- Antigens --- Bacterial immunoglobulin-binding proteins --- Conjugates, Antibody-drug --- Drug-antibody conjugates --- Drug immunoconjugates --- Drug-immunoglobulin conjugates --- Immunoconjugates, Drug --- Immunoglobulin-drug conjugates --- Bioconjugates --- Drugs --- Immunopharmacology --- Dosage forms

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

The concept of delivering ‘magic bullets’ to treat diseases was first proposed by Paul Erlich in the early 1900’s.  The realization of this concept for the treatment of cancer occurred in the late 1990’s with the approval of monoclonal antibody therapies.  The use of monoclonal antibodies conjugated (linked) to potent cytotoxic agents (antibody-drug conjugates, ADCs) for specifically delivering cytotoxics to cancer cells was an obvious extension of antibody-based therapy.  ADCs have been under intense investigation for several decades; progress, however, has been limited due to toxicity or lack of improved efficacy compared to unconjugated cytotoxics.  More recently, linker technology and target selection have advanced such that several ADCs and immunotoxins are undergoing clinical testing or are approved for use.  This important volume gives the latest and most comprehensive information on the topic, describing different types of ADCs and immunotoxins for both hematologic and solid malignancies. Finally, the volume highlights the promise that this technology holds for diverse types of human cancer.

Antibodies. --- Antibody-drug conjugates. --- Immunotoxins -- Therapeutic use. --- Antibody-drug conjugates --- Antibody-toxin conjugates --- Diseases --- Pharmaceutical Preparations --- Immunoconjugates --- Immunoglobulins --- Therapeutics --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Immunoproteins --- Chemicals and Drugs --- Blood Proteins --- Proteins --- Amino Acids, Peptides, and Proteins --- Immunotoxins --- Neoplasms --- Drug Therapy --- Antibodies --- Drug Combinations --- Medicine --- Health & Biological Sciences --- Oncology --- Antibody-toxin conjugates. --- Conjugates, Antibody-toxin --- Immunoglobulin-toxin conjugates --- Toxin-antibody conjugates --- Toxin-immunoglobulin conjugates --- Conjugates, Antibody-drug --- Drug-antibody conjugates --- Drug immunoconjugates --- Drug-immunoglobulin conjugates --- Immunoconjugates, Drug --- Immunoglobulin-drug conjugates --- Medicine. --- Cancer research. --- Biomedicine. --- Cancer Research. --- Biomedicine general. --- Immune globulins --- Immune serum globulin --- Blood proteins --- Globulins --- Plasma cells --- Antibody diversity --- Antigens --- Bacterial immunoglobulin-binding proteins --- Cancer research --- Clinical sciences --- Medical profession --- Human biology --- Life sciences --- Medical sciences --- Pathology --- Physicians --- Bioconjugates --- Immunopharmacology --- Immunotoxicology --- Toxins --- Drugs --- Dosage forms --- Oncology. --- Monoclonal antibodies. --- Antibodies, Monoclonal --- Monoclonal immunoglobulins --- Molecular cloning --- Tumors --- Health Workforce --- Biomedicine, general.

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

Glycoconjugates --- Congresses. --- Congresses --- Cell Membrane. --- Cell membrane --- Cell Membrane --- Glycoconjugate --- Glycoproteins --- Glycosylation --- Golgi apparatus --- Oligosaccharides, conjugates