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Recent years have seen the idea of a close association between nutrition and the modulation of cancer development/progression reinforced. An increasing amount of experimental and epidemiological evidence has been produced supporting the concept that many different bioactive components of food (e.g. polyphenols, mono- and polyunsaturated fatty acids, methyl-group donors, etc.) may be implicated in either the promotion of or the protection against carcinogenesis. At the cellular level, such compounds can have an impact on different but sometimes intertwined processes, such as growth and differentiation, DNA repair, programmed cell death, and oxidative stress. In addition, compelling evidence is starting to build up of the existence of primary epigenetic targets of dietary compounds, such as oncogenic/oncosuppressor miRNAs or DNA-modifying enzymes, which in turn impair gene expression and function. Since there is a growing interest in the study of the biochemical and molecular role played by food components and its impact on cellular processes and/or gene expressions directed towards the fine-tuning of cancer phenotypes, in this Special Issue researchers contributed with either research or review articles presenting the latest findings on the intracellular pathways and mechanisms affected by natural bioactive dietary molecules.

Research & information: general --- Biology, life sciences --- berberine --- signaling pathways --- oncogenic cascades --- TRAIL --- microRNAs --- cancer therapy --- colon cancer cells --- ethanol --- Nrf2 --- HO-1 --- ER stress --- autophagy --- MMPs --- formononetin --- cancer --- preclinical models --- cell signaling --- angiogenesis --- nobiletin --- colorectal cancer --- chemoprevention --- bioactivities --- experimental therapeutics --- HDAC --- multiple myeloma --- oleacein --- breast cancer --- persistent organic pollutants --- breast cancer risk --- breast cancer prognostic --- systematic review --- carrageenan --- invasion --- metastasis --- RacGAP1 --- radiotherapy --- marine sponge --- natural product --- anticancer drug --- oral cancer inhibition --- phytochemicals --- small organic agents --- Piper eriopodon, alkenylphenols --- human cancer cells --- cell death --- apoptosis --- caspase-independent cell death --- XIAP antagonists --- XIAP-BIR3 domain --- Calocedrus formosana --- lung cancer --- yatein --- cell-cycle arrest --- xenograft --- isorhamnetin --- G2/M arrest --- ROS --- AMPK --- pancreatic cancer --- epigallocatechin-3-gallate (EGCG) --- gemcitabine --- glycolysis --- phosphofructokinase --- natural polyphenols --- anticancer activities --- molecular mechanisms --- Streptomyces --- mangrove --- anti-proliferative --- colon cancer --- epithelial mesenchymal transition --- inflammation --- malignant cancer --- natural anti-inflammatory compounds --- pro-resolving lipids --- anticancer drugs --- flavonoids --- natural compounds --- Xenopus laevis --- AOM/DSS model --- melanoma cells --- nicotine --- α9-nAChR --- PD-L1 --- STAT3 --- gigantol --- AKT --- JAK/STAT --- cancer stem cell --- tumor maintenance --- tumor density --- proteomics --- honokiol --- anticancer --- mechanism --- signalling pathway --- uterine sarcoma --- fucoidan --- isobolography --- colchicine alkaloid --- mesoporous silica nanoparticles --- targeted delivery system --- PD-1 immune checkpoint inhibitor and cancer immunotherapy --- glucose transport --- drugs --- innate immunity --- β-glucans --- nutrition --- immunotherapy --- estrogen --- estrogen receptor alpha --- polyphenols --- daidzein --- daidzein metabolites --- paclitaxel --- breast cancer cells --- obesity --- renin–angiotensin system --- eicosapentaenoic acid --- adipocyte inflammation --- olive leaf extract --- oleuropein --- Seahorse analysis --- cancer metabolism --- glycolytic markers --- Malva pseudolavatera Webb &amp --- Berthel. --- acute myeloid leukemia --- reactive oxygen species --- brain cancer --- gliomas --- schwannomas --- malignant tumors of the peripheral nerve sheath (MPNST) --- neurofibromas --- bioavailability --- nanoparticle-based delivery systems --- natural bioactive compound --- gallic acid --- EGFR signaling --- p53 --- EGCG --- non-coding RNAs --- anti-cancer drug --- NSCLC --- EGFR TKI --- FASN inhibitors --- resistance --- n/a --- renin-angiotensin system

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• Reference Manager
• EndNote
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Recent years have seen the idea of a close association between nutrition and the modulation of cancer development/progression reinforced. An increasing amount of experimental and epidemiological evidence has been produced supporting the concept that many different bioactive components of food (e.g. polyphenols, mono- and polyunsaturated fatty acids, methyl-group donors, etc.) may be implicated in either the promotion of or the protection against carcinogenesis. At the cellular level, such compounds can have an impact on different but sometimes intertwined processes, such as growth and differentiation, DNA repair, programmed cell death, and oxidative stress. In addition, compelling evidence is starting to build up of the existence of primary epigenetic targets of dietary compounds, such as oncogenic/oncosuppressor miRNAs or DNA-modifying enzymes, which in turn impair gene expression and function. Since there is a growing interest in the study of the biochemical and molecular role played by food components and its impact on cellular processes and/or gene expressions directed towards the fine-tuning of cancer phenotypes, in this Special Issue researchers contributed with either research or review articles presenting the latest findings on the intracellular pathways and mechanisms affected by natural bioactive dietary molecules.

berberine --- signaling pathways --- oncogenic cascades --- TRAIL --- microRNAs --- cancer therapy --- colon cancer cells --- ethanol --- Nrf2 --- HO-1 --- ER stress --- autophagy --- MMPs --- formononetin --- cancer --- preclinical models --- cell signaling --- angiogenesis --- nobiletin --- colorectal cancer --- chemoprevention --- bioactivities --- experimental therapeutics --- HDAC --- multiple myeloma --- oleacein --- breast cancer --- persistent organic pollutants --- breast cancer risk --- breast cancer prognostic --- systematic review --- carrageenan --- invasion --- metastasis --- RacGAP1 --- radiotherapy --- marine sponge --- natural product --- anticancer drug --- oral cancer inhibition --- phytochemicals --- small organic agents --- Piper eriopodon, alkenylphenols --- human cancer cells --- cell death --- apoptosis --- caspase-independent cell death --- XIAP antagonists --- XIAP-BIR3 domain --- Calocedrus formosana --- lung cancer --- yatein --- cell-cycle arrest --- xenograft --- isorhamnetin --- G2/M arrest --- ROS --- AMPK --- pancreatic cancer --- epigallocatechin-3-gallate (EGCG) --- gemcitabine --- glycolysis --- phosphofructokinase --- natural polyphenols --- anticancer activities --- molecular mechanisms --- Streptomyces --- mangrove --- anti-proliferative --- colon cancer --- epithelial mesenchymal transition --- inflammation --- malignant cancer --- natural anti-inflammatory compounds --- pro-resolving lipids --- anticancer drugs --- flavonoids --- natural compounds --- Xenopus laevis --- AOM/DSS model --- melanoma cells --- nicotine --- α9-nAChR --- PD-L1 --- STAT3 --- gigantol --- AKT --- JAK/STAT --- cancer stem cell --- tumor maintenance --- tumor density --- proteomics --- honokiol --- anticancer --- mechanism --- signalling pathway --- uterine sarcoma --- fucoidan --- isobolography --- colchicine alkaloid --- mesoporous silica nanoparticles --- targeted delivery system --- PD-1 immune checkpoint inhibitor and cancer immunotherapy --- glucose transport --- drugs --- innate immunity --- β-glucans --- nutrition --- immunotherapy --- estrogen --- estrogen receptor alpha --- polyphenols --- daidzein --- daidzein metabolites --- paclitaxel --- breast cancer cells --- obesity --- renin–angiotensin system --- eicosapentaenoic acid --- adipocyte inflammation --- olive leaf extract --- oleuropein --- Seahorse analysis --- cancer metabolism --- glycolytic markers --- Malva pseudolavatera Webb &amp --- Berthel. --- acute myeloid leukemia --- reactive oxygen species --- brain cancer --- gliomas --- schwannomas --- malignant tumors of the peripheral nerve sheath (MPNST) --- neurofibromas --- bioavailability --- nanoparticle-based delivery systems --- natural bioactive compound --- gallic acid --- EGFR signaling --- p53 --- EGCG --- non-coding RNAs --- anti-cancer drug --- NSCLC --- EGFR TKI --- FASN inhibitors --- resistance --- n/a --- renin-angiotensin system

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With the development of analytical instruments, the academic system has become more complicated, producing new journals one after another. Therefore, it became much important to clarify what is original of “Medicines”. As the name Medicines indicates, it includes science and practice of caring for a patient and managing the diagnosis, prognosis, prevention, treatment or palliation of their injury or disease. Therefore, Medicines differs from other journals with similar title in that it covers a wide range of fields, from traditional medicine to rapidly developing molecular-targeted drugs, focusing on their pharmacological effects, structure–activity relationships, metabolic pathways, gene expression, using cultured cells, animals, and clinical trials. Most parts of this Special Issue were written by our editorial board members, who described the research topics and how they are engaged in their field of research. All of these articles are their life-long story. We collected a total number of 22 original works by basic researchers and clinical doctors. We hope that readers can get a chance to know the current status of diverse fields of medicines, and what your most important research themes are after reading these articles.

Medicine --- Hedychium --- traditional medicine --- coronarin D --- villosin --- anti-acetylcholinesterase --- antidiabetic --- anti-inflammatory --- antimicrobial --- antioxidant --- antitumor --- Genista tridentata --- Pterospartum tridentatum --- isoflavones --- flavonols --- genistein --- biochanin A --- rutin --- daidzein --- inflammatory bowel disease --- Crohn’s disease --- ulcerative colitis --- extra-intestinal manifestations --- orofacial granulomatosis --- tag-like lesions --- cobblestoning --- mucogingivitis --- lip swelling --- aphthous stomatitis --- Angelicae Sinensis Radix --- Danggui --- granules --- herb --- multivariate analysis --- ultra-performance liquid chromatography --- Tai Chi --- qigong --- immune system --- immunity --- inflammation --- telemedicine --- remote monitoring --- GER-e-TEC --- elderly patient --- artificial intelligence --- geriatric syndromes --- detection of the precursory signs of decompensation of geriatric syndromes --- renal cell cancer --- genomic landscape --- targeted therapy --- tumor evolution --- tumor heterogeneity --- allergic rhinitis --- quercetin --- human CD4+ T cells --- Th1/Th2 cytokine balance --- modulation --- in vitro --- intravascular catheter --- CRBSI --- biofilm --- CVC --- antifouling --- chromone --- tumor specificity --- QSAR analysis --- apoptosis --- cell cycle analysis --- contrast-enhanced ultrasound --- hepatocellular carcinoma --- LI-RADS --- chronic liver disease --- granuloma annulare --- granulomatous disorders of the skin --- inflammatory skin conditions --- medical dermatology --- biliary tract cancer --- cholangiocarcinoma --- PARP --- BRCA --- olaparib --- rucaparib --- liver cancer --- pancreatic adenocarcinoma --- pancreatic cancer --- sarcoidosis --- superior vena cava syndrome --- venous thrombosis --- RUCAM --- Roussel Uclaf Causality Assessment Method --- diagnostic algorithm --- iDILI --- iDrug induced liver injury --- DILI --- HILI --- herb induced liver injury --- Stachys L. --- traditional uses --- pharmacological activities --- phytochemicals --- bioactive compounds --- Kampo formulae --- alkaline extract of Sasa sp. --- pine cone extract --- povidone-iodine --- HSV --- HIV --- loss of infectivity --- solubilization method --- diaphragmatic breathing --- abdominal breathing --- breathing exercise --- systematic review --- randomized controlled trial --- respiratory function --- auricular acupuncture --- preoperative anxiety --- protocol --- randomized controlled trials --- meta-analysis --- boiogito --- knee osteoarthritis --- rat --- Yokukansan --- fentanyl --- transient receptor potential ankyrin 1 (TRPA1) channel --- phosphorylated extracellular signal-regulated kinase (pERK) --- whole-cell patch-clamp recording --- herbal medicine --- calcium metabolism --- bone metabolism --- protease --- osteoclast --- macrophage --- RANKL --- LPS --- TLR4 --- TREM2

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

With the development of analytical instruments, the academic system has become more complicated, producing new journals one after another. Therefore, it became much important to clarify what is original of “Medicines”. As the name Medicines indicates, it includes science and practice of caring for a patient and managing the diagnosis, prognosis, prevention, treatment or palliation of their injury or disease. Therefore, Medicines differs from other journals with similar title in that it covers a wide range of fields, from traditional medicine to rapidly developing molecular-targeted drugs, focusing on their pharmacological effects, structure–activity relationships, metabolic pathways, gene expression, using cultured cells, animals, and clinical trials. Most parts of this Special Issue were written by our editorial board members, who described the research topics and how they are engaged in their field of research. All of these articles are their life-long story. We collected a total number of 22 original works by basic researchers and clinical doctors. We hope that readers can get a chance to know the current status of diverse fields of medicines, and what your most important research themes are after reading these articles.

Hedychium --- traditional medicine --- coronarin D --- villosin --- anti-acetylcholinesterase --- antidiabetic --- anti-inflammatory --- antimicrobial --- antioxidant --- antitumor --- Genista tridentata --- Pterospartum tridentatum --- isoflavones --- flavonols --- genistein --- biochanin A --- rutin --- daidzein --- inflammatory bowel disease --- Crohn’s disease --- ulcerative colitis --- extra-intestinal manifestations --- orofacial granulomatosis --- tag-like lesions --- cobblestoning --- mucogingivitis --- lip swelling --- aphthous stomatitis --- Angelicae Sinensis Radix --- Danggui --- granules --- herb --- multivariate analysis --- ultra-performance liquid chromatography --- Tai Chi --- qigong --- immune system --- immunity --- inflammation --- telemedicine --- remote monitoring --- GER-e-TEC --- elderly patient --- artificial intelligence --- geriatric syndromes --- detection of the precursory signs of decompensation of geriatric syndromes --- renal cell cancer --- genomic landscape --- targeted therapy --- tumor evolution --- tumor heterogeneity --- allergic rhinitis --- quercetin --- human CD4+ T cells --- Th1/Th2 cytokine balance --- modulation --- in vitro --- intravascular catheter --- CRBSI --- biofilm --- CVC --- antifouling --- chromone --- tumor specificity --- QSAR analysis --- apoptosis --- cell cycle analysis --- contrast-enhanced ultrasound --- hepatocellular carcinoma --- LI-RADS --- chronic liver disease --- granuloma annulare --- granulomatous disorders of the skin --- inflammatory skin conditions --- medical dermatology --- biliary tract cancer --- cholangiocarcinoma --- PARP --- BRCA --- olaparib --- rucaparib --- liver cancer --- pancreatic adenocarcinoma --- pancreatic cancer --- sarcoidosis --- superior vena cava syndrome --- venous thrombosis --- RUCAM --- Roussel Uclaf Causality Assessment Method --- diagnostic algorithm --- iDILI --- iDrug induced liver injury --- DILI --- HILI --- herb induced liver injury --- Stachys L. --- traditional uses --- pharmacological activities --- phytochemicals --- bioactive compounds --- Kampo formulae --- alkaline extract of Sasa sp. --- pine cone extract --- povidone-iodine --- HSV --- HIV --- loss of infectivity --- solubilization method --- diaphragmatic breathing --- abdominal breathing --- breathing exercise --- systematic review --- randomized controlled trial --- respiratory function --- auricular acupuncture --- preoperative anxiety --- protocol --- randomized controlled trials --- meta-analysis --- boiogito --- knee osteoarthritis --- rat --- Yokukansan --- fentanyl --- transient receptor potential ankyrin 1 (TRPA1) channel --- phosphorylated extracellular signal-regulated kinase (pERK) --- whole-cell patch-clamp recording --- herbal medicine --- calcium metabolism --- bone metabolism --- protease --- osteoclast --- macrophage --- RANKL --- LPS --- TLR4 --- TREM2