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Materials science and engineering are strongly developing tools with increasing impact in the biotechnological and biomedical areas. Interestingly, research in molecular and cellular biology is often at the core of the design and development of materials-based approaches, providing biological rationale. Focused on research relying on biology–materials interaction, IJMS launched a Special Issue named “Cells and Materials for Disease Modeling and Regenerative Medicine”. The aim of the Special Issue was to generate a compilation of in vitro and in vivo strategies based on cell–material interactions. This book compiles the papers published in that Special Issue and includes a selection of six original scientific experimental articles and six comprehensive reviews. We are convinced that this collection of articles shows representative examples of the state of the art in the field, unveiling the relevance of materials research in generating new regenerative medicine and disease modeling approaches.

Leigh syndrome --- mitochondrial disorder --- iPSC --- NSC --- neuron --- disease modeling --- mtDNA --- high hydrostatic pressure --- devitalization --- decellularization --- allografts --- regenerative medicine --- bone and cartilage regeneration --- dentogenesis --- amelogenesis --- dentinogenesis --- cementogenesis --- drug release materials --- scaffolds --- odontogenic cells --- stem cells --- whole-tooth regeneration --- psoriasis --- cyclic adenosine monophosphate --- cholera toxin --- isoproterenol --- tissue engineering --- extracellular matrix --- collagen --- elastin --- bladder --- compliance --- microarchitecture --- biomimicry --- blood cancer --- bone marrow --- niche --- microenvironment --- 3D models --- tumor-on-a-chip --- leukemia --- myeloma --- biomaterials --- cytokines --- growth factors --- cardiac tissue regeneration --- adipose tissue --- fibrosis --- in vitro models --- in vivo models --- dental pulp stem cells --- osteogenesis --- rheumatoid arthritis --- mesenchymal stromal cells --- co-culture --- 3D cell culture --- explants --- joint-on-a-chip --- piezoelectric --- electroactive --- patterning --- cell differentiation --- bone tissue engineering

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Dear Readers, Understanding the pathological mechanisms involved in human diseases and their possible treatment has been historically based on comparative analysis of diverse animal species that share a similar genetic, physiological and behavioural composition. The ancient Greeks were the first to use animals as models for anatomy and physiology, and this was consequently adopted by other cultures and led to important discoveries. In recent years, there have been many efforts to understand and fight cancer through new revolutionary personalized treatments and wider screenings that help diagnose and treat cancer. A fundamental part of this effort is to develop suitable cancer animal models that simulate the different disease variants and their progression. Ranging from tumor-derived xenografts to genetically engineered models, a wide variety of systems are applied for this purpose, and many technological breakthroughs are changing the way cancer is studied and analyzed. In this Special Issue, we collected a set of research articles and reviews that focus on the generation of cancer animal models that are used for understanding the disease and contribute to designing and testing new drugs for cancer prevention or treatment. Vladimir Korinek Collection Editor

Research & information: general --- Biology, life sciences --- soy --- isoflavones --- mammary tumor prevention --- rodent models --- chemical carcinogens --- transgenic mice --- Zebrafish --- Drosophila --- rats --- mice --- NPM-1 --- FLT3 ITD --- ETO-1 --- IDH1/2 --- neural stem cells --- brain and nervous system cancers --- neurogenic niches --- radiotherapy --- sparing of neurogenic regions --- carcinoma --- consensus molecular subtypes --- intestine --- oncogenes --- signaling cascades --- tumor suppressors --- tumorigenesis --- MPN (myeloproliferative neoplasms) --- zebrafish --- iPSCs --- JAK2 --- MPL --- CALR --- thrombosis --- ubiquitin–proteasome system --- cancer --- mouse model --- gene inactivation --- colorectal cancer --- mouse models --- microbiota --- antitumor immunity --- melanoma --- mutation --- genetics --- animal model --- swine --- MeLiM --- progression --- spontaneous regression --- devitalization --- metaplasia --- Cdx --- animal models --- epigenetics --- xenotransplantation --- drug screen --- pre-clinical cancer model --- non-mouse models --- gene editing --- stem cells --- solid tumors --- hematologic malignancies --- soy --- isoflavones --- mammary tumor prevention --- rodent models --- chemical carcinogens --- transgenic mice --- Zebrafish --- Drosophila --- rats --- mice --- NPM-1 --- FLT3 ITD --- ETO-1 --- IDH1/2 --- neural stem cells --- brain and nervous system cancers --- neurogenic niches --- radiotherapy --- sparing of neurogenic regions --- carcinoma --- consensus molecular subtypes --- intestine --- oncogenes --- signaling cascades --- tumor suppressors --- tumorigenesis --- MPN (myeloproliferative neoplasms) --- zebrafish --- iPSCs --- JAK2 --- MPL --- CALR --- thrombosis --- ubiquitin–proteasome system --- cancer --- mouse model --- gene inactivation --- colorectal cancer --- mouse models --- microbiota --- antitumor immunity --- melanoma --- mutation --- genetics --- animal model --- swine --- MeLiM --- progression --- spontaneous regression --- devitalization --- metaplasia --- Cdx --- animal models --- epigenetics --- xenotransplantation --- drug screen --- pre-clinical cancer model --- non-mouse models --- gene editing --- stem cells --- solid tumors --- hematologic malignancies

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

Materials science and engineering are strongly developing tools with increasing impact in the biotechnological and biomedical areas. Interestingly, research in molecular and cellular biology is often at the core of the design and development of materials-based approaches, providing biological rationale. Focused on research relying on biology–materials interaction, IJMS launched a Special Issue named “Cells and Materials for Disease Modeling and Regenerative Medicine”. The aim of the Special Issue was to generate a compilation of in vitro and in vivo strategies based on cell–material interactions. This book compiles the papers published in that Special Issue and includes a selection of six original scientific experimental articles and six comprehensive reviews. We are convinced that this collection of articles shows representative examples of the state of the art in the field, unveiling the relevance of materials research in generating new regenerative medicine and disease modeling approaches.

Research & information: general --- Leigh syndrome --- mitochondrial disorder --- iPSC --- NSC --- neuron --- disease modeling --- mtDNA --- high hydrostatic pressure --- devitalization --- decellularization --- allografts --- regenerative medicine --- bone and cartilage regeneration --- dentogenesis --- amelogenesis --- dentinogenesis --- cementogenesis --- drug release materials --- scaffolds --- odontogenic cells --- stem cells --- whole-tooth regeneration --- psoriasis --- cyclic adenosine monophosphate --- cholera toxin --- isoproterenol --- tissue engineering --- extracellular matrix --- collagen --- elastin --- bladder --- compliance --- microarchitecture --- biomimicry --- blood cancer --- bone marrow --- niche --- microenvironment --- 3D models --- tumor-on-a-chip --- leukemia --- myeloma --- biomaterials --- cytokines --- growth factors --- cardiac tissue regeneration --- adipose tissue --- fibrosis --- in vitro models --- in vivo models --- dental pulp stem cells --- osteogenesis --- rheumatoid arthritis --- mesenchymal stromal cells --- co-culture --- 3D cell culture --- explants --- joint-on-a-chip --- piezoelectric --- electroactive --- patterning --- cell differentiation --- bone tissue engineering