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The health benefits of food, plants, fruits, and seaweeds stem from the biological activities of their constituents—namely, secondary metabolites. The study of secondary metabolites and their potential to treat and/or prevent a number of diseases has become a research topic of growing interest for biologists, pharmacists, and chemists. Notably, in order to propose a compound as a potential new drug with pharmacological effects, the chemical structure of this compound and its biological activity against a given target must be well established. The Special Issue, “Isolation and Identification of Bioactive Secondary Metabolites”, considers species beyond their nutritional value and identifies instances of wider and more efficient use, thereby contributing to a more sustainable management of natural resources. The fifteen articles published in this Special Issue reflect the latest research trends, and consider the isolation, identification, and assessment of the beneficial effects of secondary metabolites from both edible and inedible species. Thus, these contributions collectively demonstrate that these compounds, and their plants of origin, should be valued beyond their nutritional benefits.

Medicine --- Pharmacology --- coumarins --- Lycium --- metabolomic --- HPLC-MS --- orbitrap --- secondary metabolites --- endemic plants --- olive leaves --- supercritical fluid extraction --- antioxidants --- hyperuricemia --- plant-based functional food --- xanthine oxidase --- adenosine deaminase --- uric acid transporter --- bioactive compound --- Piper pseudoarboreum --- bioassay-guided fractionation --- leishmanicidal activity --- alkamides --- (E)-piplartine --- Wedelia chinensis --- organic farming --- phytotoxic substances --- vanillic acid --- gallic acid --- Origanum subspecies --- morphological traits --- glandular trichomes --- essential oil composition --- rosmarinic acid --- sensory evaluation --- colored potato tubers --- total phenols --- anthocyanins --- saccharides --- nutrition --- microelements --- plants --- fungi --- food supplements --- cardiovascular diseases --- neurodegenerative diseases --- Alzheimer’s disease --- metabolic syndrome --- apocarotenoid --- caffeic acid derivative --- flavonoid --- Lactuca sativa --- lignan --- megastigmane --- sesquiterpene lactone --- 1,2,3,4-tetrahydro-β-carboline-3-carboxylic acid --- black chokeberry --- anthocyanin --- simulated moving bed --- antioxidant activity --- neuroprotection --- Artemisia --- clinical trials --- health effects --- adverse effects --- anticancer --- antiparasitic --- artemisinin --- santonin --- achillin --- tehranolide --- Aglaomorpha quercifolia --- GC-MS profile --- rhizome --- leaves --- n-hexane extract --- fatty acids --- terpenoids --- linolenic acid --- hop-16-ene --- cardiac glycosides --- secondary plant metabolites --- natural product isolation --- hyrcanoside --- deglucohyrcanoside --- ouabain --- cymarin --- digitoxin --- anticancer activity --- Na+/K+-ATPase inhibitors --- corn salad --- leafy vegetables --- phytochemicals --- liquid chromatography --- mass spectrometry --- celastrol --- Celastraceae --- antimicrobial activity --- mechanism of action --- Bacillus subtilis --- n/a --- Alzheimer's disease

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The health benefits of food, plants, fruits, and seaweeds stem from the biological activities of their constituents—namely, secondary metabolites. The study of secondary metabolites and their potential to treat and/or prevent a number of diseases has become a research topic of growing interest for biologists, pharmacists, and chemists. Notably, in order to propose a compound as a potential new drug with pharmacological effects, the chemical structure of this compound and its biological activity against a given target must be well established. The Special Issue, “Isolation and Identification of Bioactive Secondary Metabolites”, considers species beyond their nutritional value and identifies instances of wider and more efficient use, thereby contributing to a more sustainable management of natural resources. The fifteen articles published in this Special Issue reflect the latest research trends, and consider the isolation, identification, and assessment of the beneficial effects of secondary metabolites from both edible and inedible species. Thus, these contributions collectively demonstrate that these compounds, and their plants of origin, should be valued beyond their nutritional benefits.

Medicine --- Pharmacology --- coumarins --- Lycium --- metabolomic --- HPLC-MS --- orbitrap --- secondary metabolites --- endemic plants --- olive leaves --- supercritical fluid extraction --- antioxidants --- hyperuricemia --- plant-based functional food --- xanthine oxidase --- adenosine deaminase --- uric acid transporter --- bioactive compound --- Piper pseudoarboreum --- bioassay-guided fractionation --- leishmanicidal activity --- alkamides --- (E)-piplartine --- Wedelia chinensis --- organic farming --- phytotoxic substances --- vanillic acid --- gallic acid --- Origanum subspecies --- morphological traits --- glandular trichomes --- essential oil composition --- rosmarinic acid --- sensory evaluation --- colored potato tubers --- total phenols --- anthocyanins --- saccharides --- nutrition --- microelements --- plants --- fungi --- food supplements --- cardiovascular diseases --- neurodegenerative diseases --- Alzheimer’s disease --- metabolic syndrome --- apocarotenoid --- caffeic acid derivative --- flavonoid --- Lactuca sativa --- lignan --- megastigmane --- sesquiterpene lactone --- 1,2,3,4-tetrahydro-β-carboline-3-carboxylic acid --- black chokeberry --- anthocyanin --- simulated moving bed --- antioxidant activity --- neuroprotection --- Artemisia --- clinical trials --- health effects --- adverse effects --- anticancer --- antiparasitic --- artemisinin --- santonin --- achillin --- tehranolide --- Aglaomorpha quercifolia --- GC-MS profile --- rhizome --- leaves --- n-hexane extract --- fatty acids --- terpenoids --- linolenic acid --- hop-16-ene --- cardiac glycosides --- secondary plant metabolites --- natural product isolation --- hyrcanoside --- deglucohyrcanoside --- ouabain --- cymarin --- digitoxin --- anticancer activity --- Na+/K+-ATPase inhibitors --- corn salad --- leafy vegetables --- phytochemicals --- liquid chromatography --- mass spectrometry --- celastrol --- Celastraceae --- antimicrobial activity --- mechanism of action --- Bacillus subtilis --- n/a --- Alzheimer's disease

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Essential oils (EOs) and microbial/plant-based volatile organic compounds (VOCs) are being used in an increasing number of sectors such as health, cosmetics, the food industry and, more recently, agronomy. In agronomy, they are employed as bio-herbicides and bio-pesticides due to their their insecticidal, antifungal, and bactericidal effects. Several EO-based bio-pesticides are already registered. Essential oils and other VOCs are 100% bio-based and present numerous additional advantages. They contain a great number of structurally diverse compounds that frequently act in synergy; they are thus less subject to resistance. As highly volatile compounds are found in EOs and VOCs, they typically cause no residue problems in food products or in soils. Indeed, the supply of EOs can be really challenging because they are frequently produced in restricted areas of the world with prices and chemical composition fluctuations. Besides, while the high volatility of EOs and VOCs is interesting for some specific applications, it can be a problem when developing a bio-pesticide with long lasting effects. Finally, EOs are frequently phytotoxic, which is perfect for herbicide formulations, but not for other applications. In both cases, the development of a proper formulation is essential. Owing to the current attraction for natural products, a better understanding of their modes of biological action is of importance for the development of new and optimal applications.

natural antimicrobials --- encapsulation --- shelf-life --- microbiological quality --- micelles --- plant-derived antimicrobial --- Enteric pathogens --- leafy greens --- cheese --- essential oils --- Escherichia coli --- Clostridium tyrobutyricum --- Penicillium verrucosum --- antimicrobial --- Elsholtzia ciliata --- Tribolium castaneum --- essential oil --- carvone --- limonene --- insecticidal activity --- synergistic effect --- starch films --- active food packaging films --- cinnamon oil emulsions --- Botrytis cinerea --- Zanthoxylum leprieurii --- Sitophilus granarius --- tridecan-2-one --- β-myrcene --- (E)-β-ocimene --- dendrolasin --- antioxidant --- anti-inflammatory --- insecticidal --- anti-plasmodial --- Côte d’Ivoire --- Staphylococcus aureus --- S. epidermidis --- carvacrol --- thymol --- eugenol --- benzalkonium chloride --- biofilms --- planktonic --- disinfection --- natural products --- Aphis nerii --- Coccinella septempunctata --- plant-based insecticide --- Oryzaephius surinamensis --- Rhyzopertha dominica --- Trogoderma granarium --- thyme --- edible films --- high pressure thermal treatment --- ultrasonication --- food safety --- essential oil composition --- sabinene --- citronellal --- Sitophilus oryzae --- marinating solution --- pork loin --- quality --- safety --- phytotoxicity --- mode of action --- biopesticides --- biocontrol --- antifungal --- antibacterial --- biopesticide --- insecticide --- eco-friendly --- stored product pest --- Allium sativum --- Gaultheria procumbens --- Mentha arvensis --- Eucalyptus dives --- controlled release --- biosourced --- surface response methodology --- sweet wormwood --- mulberry pyralid --- mulberry --- immunity --- reproductive system --- digestive system --- n/a --- Côte d'Ivoire