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This book focuses on the design of polymeric delivery systems for biomedical and nanomedicine applications as well as on understanding how such biomaterials interact in the physiological environment. The reader will find an encompassing view on the state-of-the-art of polymeric carriers, showing how current research deals with new stimuli-responsive systems for cancer therapies and biomedical challenges, namely overcoming the skin barrier. The published papers cover topics ranging from novel production methods and insights on hybrid polymers to applications as diverse as nanoparticles, hydrogels and microneedles for antifungal skin therapy, peptide and siRNA delivery, enhanced skin absorption of bioactive molecules, and anticancer therapy. The book comprises one review paper and nine research papers.

Technology: general issues --- osteoarthritis --- monosodium iodoacetate --- p47phox --- PLGA nanoparticles --- reactive oxygen species --- full factorial design --- optimization --- metronidazole --- nanocomposites --- sodium alginate --- chitosan --- PLGA --- hybrid polymers --- chitosan-PLGA polymer --- NMR --- DSC --- FT-IR --- covalent drug conjugation --- therapeutic nanodevice --- polymeric nanoparticles --- cancer therapy --- controlled drug delivery --- redox responsive PEG-block-PLA --- nanocarriers --- disulfide bond --- controlled release --- retinol --- nanosponge --- hydrogel --- Box–Behnken design --- pharmacokinetic --- terbinafine hydrogel --- niacinamide --- polyethene glycol (PEG) 400 --- solvent --- dermal delivery --- finite dose --- porcine skin --- dissolving microneedles --- multiple sclerosis --- PLP --- transdermal delivery --- tyrosol --- nanoparticles --- Design of Experiment (DoE) --- β cyclodextrin --- DNA binding --- glyconanoparticles --- immunotherapy --- infectious diseases --- mannose receptors --- nutraceuticals --- n/a --- Box-Behnken design

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Nowadays, the impact of nanotechnology on applications in medicine and biomedical sciences has broader societal and economic effects, enhancing awareness of the business, regulatory, and administrative aspects of medical applications. The selected papers included in the present Special Issue gives readers a critical, balanced and realistic evaluation of existing nanomedicine developments and future prospects, allowing practitioners to plan and make decisions.The topics of this book covers the use of nanoparticles and nanotechnology in medical applications including biomaterials for tissue regeneration, diagnosis and monitoring, surgery, prosthetics, drug delivery systems, nanocarriers, and wound dressing. I would like to express my gratitude to all contributors to this issue, who have given so much of their time and effort to help create this collection of high quality papers.

titanium cranioplasty --- endoprosthesis --- patented solutions --- amniotic membrane --- FTIR spectroscopy --- immunohistochemistry --- AFM --- UV light --- antibiotic --- pterygium surgery --- selenium nanoparticles --- Lactobacillus casei --- cadmium --- antioxidant enzymes --- liver --- histology --- anti-apoptotic --- anti-inflammatory --- endodontic sealer --- CNTs --- chlorhexidine --- silver nanoparticles --- antimicrobial --- liposomes --- hyaluronic acid --- full-factorial --- berberine --- bioavailability --- metal nanoparticles --- carbon-based nanomaterials --- screen-printed electrodes --- electrochemical (bio)sensors --- biomedical applications --- PMMA bone cements --- peppermint essential oil --- gentamicin --- antimicrobial properties --- nanomedicine --- nanoparticles --- phytomedicine --- bioinformatics --- neurodegenerative diseases --- silver --- gold nanocages --- in vitro bioactivity --- antibacterial activity --- electrospinning --- nanofibers --- implants --- wound healing --- targeted delivery --- biopolymers --- ZnO-NPs --- traditional synthesis --- green synthesis --- toxicity --- gatifloxacin --- cubosomal dispersion --- MIC --- corneal permeation --- methicillin resistant Staphylococcus aureus --- keratitis --- hepatocellular carcinoma --- cancer diagnosis --- targeting --- smart therapy

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Nowadays, the impact of nanotechnology on applications in medicine and biomedical sciences has broader societal and economic effects, enhancing awareness of the business, regulatory, and administrative aspects of medical applications. The selected papers included in the present Special Issue gives readers a critical, balanced and realistic evaluation of existing nanomedicine developments and future prospects, allowing practitioners to plan and make decisions.The topics of this book covers the use of nanoparticles and nanotechnology in medical applications including biomaterials for tissue regeneration, diagnosis and monitoring, surgery, prosthetics, drug delivery systems, nanocarriers, and wound dressing. I would like to express my gratitude to all contributors to this issue, who have given so much of their time and effort to help create this collection of high quality papers.

Technology: general issues --- titanium cranioplasty --- endoprosthesis --- patented solutions --- amniotic membrane --- FTIR spectroscopy --- immunohistochemistry --- AFM --- UV light --- antibiotic --- pterygium surgery --- selenium nanoparticles --- Lactobacillus casei --- cadmium --- antioxidant enzymes --- liver --- histology --- anti-apoptotic --- anti-inflammatory --- endodontic sealer --- CNTs --- chlorhexidine --- silver nanoparticles --- antimicrobial --- liposomes --- hyaluronic acid --- full-factorial --- berberine --- bioavailability --- metal nanoparticles --- carbon-based nanomaterials --- screen-printed electrodes --- electrochemical (bio)sensors --- biomedical applications --- PMMA bone cements --- peppermint essential oil --- gentamicin --- antimicrobial properties --- nanomedicine --- nanoparticles --- phytomedicine --- bioinformatics --- neurodegenerative diseases --- silver --- gold nanocages --- in vitro bioactivity --- antibacterial activity --- electrospinning --- nanofibers --- implants --- wound healing --- targeted delivery --- biopolymers --- ZnO-NPs --- traditional synthesis --- green synthesis --- toxicity --- gatifloxacin --- cubosomal dispersion --- MIC --- corneal permeation --- methicillin resistant Staphylococcus aureus --- keratitis --- hepatocellular carcinoma --- cancer diagnosis --- targeting --- smart therapy

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The demand for computational fluid dynamics (CFD)-based numerical techniques is increasing rapidly with the development of the computing power system. These advanced CFD techniques are applicable to various issues in the industrial engineering fields and especially contribute to the design of fluid machinery and fluid devices, which have very complicated unsteady flow phenomena and physics. In other words, to aid the rapid development of CFD techniques, the performances of fluid machinery and fluid devices with complicated unsteady flows have been enhanced significantly. In addition, many persistently troublesome problems of fluid machinery and fluid devices such as flow instability, rotor–stator interaction, surging, cavitation, vibration, and noise are solved clearly using advanced CFD techniques.This Special Issue on “CFD-Based Research and Applications for Fluid Machinery and Fluid Devices” aims to present recent novel research trends based on advanced CFD techniques for fluid machinery and fluid devices. The following topics, among others, are included in this issue:- CFD techniques and applications in fluid machinery and fluid devices;- Unsteady and transient phenomena in fluid machinery and fluid devices;- Pumps, fans, compressors, hydraulic turbines, pump turbines, valves, etc.

Technology: general issues --- centrifugal fan --- noise characteristics --- power consumption --- negative pressure --- sound pressure --- mechanical seal --- dynamic characteristics --- extrusion fault --- numerical simulation --- sealing performance --- fluent --- inducer --- step casing --- varying pitch --- cavitating flow and instabilities --- partial similarity principle --- flow similarity --- stability improvement --- multi-condition optimization --- cavitation performance --- artificial neural networks (ANN) --- net positive suction head (NPSH) --- double suction --- cascade --- aerodynamic --- parameterization --- plane cascade design --- incidence angle --- PSO-MVFSA --- optimization --- two-vane pump --- Computational Fluid Dynamics (CFD) --- Reynolds-averaged Navier-Stokes (RANS) --- machine learning --- energy recovery --- pump as turbine --- vortex --- hydraulic losses --- pressure fluctuation --- transient characteristics --- centrifugal pump --- startup period --- solar air heater --- ribs --- Nusselt number --- friction factor --- Reynolds-averaged Navier–Stokes equations --- thrust coefficient --- power coefficient --- figure of merit --- frozen rotor --- UAV --- octorotor SUAV --- aerodynamic performance --- rotor spacing --- hover --- CFD --- vortices distribution --- shape optimization --- Francis turbine --- fixed flow passage --- flow uniformity --- blade outlet angle --- Sirocco fan --- URANS --- volute tongue radius --- internal flow --- noise --- film cooling --- large eddy simulation --- triple holes --- blowing ratio --- adiabatic film-cooling effectiveness --- proper orthogonal decomposition --- axial compressor --- tip clearance --- flow field --- clearance --- flow function --- gas turbine --- leakage --- pressure ratio --- stepped labyrinth seal --- axial-flow pump --- root clearance radius --- computational fluid dynamics --- entropy production --- energy dissipation --- vortex pump --- lateral cavity --- open-design --- spiral flow --- reactor coolant pump (RCP) --- waviness --- leakage rate --- liquid film --- axial fan --- reversible --- jet --- design --- thrust --- energy characteristics --- mixing --- pitched blade turbine --- impeller --- inverse design method --- matching optimization --- diffuser --- small hydropower --- tubular turbine --- fish farm --- performance test --- design factors --- optimum model --- the mixed free-surface-pressurized flow --- characteristic implicit method --- relative roughness --- vent holes --- optimization control --- microchannel heat sink --- wavy microchannel --- groove --- heat transfer performance --- laminar flow --- multi-objective optimization --- LHS --- full factorial methods --- pump-turbine --- dynamic stress --- start-up process --- vortex generator (VG) --- computational fluid dynamics (CFD) --- cell-set model --- RANS --- LES --- multistage centrifugal pump --- double-suction impeller --- twin-volute --- inducer-type guide vane --- trailing edge flap (TEF) --- trailing edge flap with Micro-Tab --- deflection angle of the flap (αF) --- n/a --- Reynolds-averaged Navier-Stokes equations

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The demand for computational fluid dynamics (CFD)-based numerical techniques is increasing rapidly with the development of the computing power system. These advanced CFD techniques are applicable to various issues in the industrial engineering fields and especially contribute to the design of fluid machinery and fluid devices, which have very complicated unsteady flow phenomena and physics. In other words, to aid the rapid development of CFD techniques, the performances of fluid machinery and fluid devices with complicated unsteady flows have been enhanced significantly. In addition, many persistently troublesome problems of fluid machinery and fluid devices such as flow instability, rotor–stator interaction, surging, cavitation, vibration, and noise are solved clearly using advanced CFD techniques.This Special Issue on “CFD-Based Research and Applications for Fluid Machinery and Fluid Devices” aims to present recent novel research trends based on advanced CFD techniques for fluid machinery and fluid devices. The following topics, among others, are included in this issue:- CFD techniques and applications in fluid machinery and fluid devices;- Unsteady and transient phenomena in fluid machinery and fluid devices;- Pumps, fans, compressors, hydraulic turbines, pump turbines, valves, etc.

centrifugal fan --- noise characteristics --- power consumption --- negative pressure --- sound pressure --- mechanical seal --- dynamic characteristics --- extrusion fault --- numerical simulation --- sealing performance --- fluent --- inducer --- step casing --- varying pitch --- cavitating flow and instabilities --- partial similarity principle --- flow similarity --- stability improvement --- multi-condition optimization --- cavitation performance --- artificial neural networks (ANN) --- net positive suction head (NPSH) --- double suction --- cascade --- aerodynamic --- parameterization --- plane cascade design --- incidence angle --- PSO-MVFSA --- optimization --- two-vane pump --- Computational Fluid Dynamics (CFD) --- Reynolds-averaged Navier-Stokes (RANS) --- machine learning --- energy recovery --- pump as turbine --- vortex --- hydraulic losses --- pressure fluctuation --- transient characteristics --- centrifugal pump --- startup period --- solar air heater --- ribs --- Nusselt number --- friction factor --- Reynolds-averaged Navier–Stokes equations --- thrust coefficient --- power coefficient --- figure of merit --- frozen rotor --- UAV --- octorotor SUAV --- aerodynamic performance --- rotor spacing --- hover --- CFD --- vortices distribution --- shape optimization --- Francis turbine --- fixed flow passage --- flow uniformity --- blade outlet angle --- Sirocco fan --- URANS --- volute tongue radius --- internal flow --- noise --- film cooling --- large eddy simulation --- triple holes --- blowing ratio --- adiabatic film-cooling effectiveness --- proper orthogonal decomposition --- axial compressor --- tip clearance --- flow field --- clearance --- flow function --- gas turbine --- leakage --- pressure ratio --- stepped labyrinth seal --- axial-flow pump --- root clearance radius --- computational fluid dynamics --- entropy production --- energy dissipation --- vortex pump --- lateral cavity --- open-design --- spiral flow --- reactor coolant pump (RCP) --- waviness --- leakage rate --- liquid film --- axial fan --- reversible --- jet --- design --- thrust --- energy characteristics --- mixing --- pitched blade turbine --- impeller --- inverse design method --- matching optimization --- diffuser --- small hydropower --- tubular turbine --- fish farm --- performance test --- design factors --- optimum model --- the mixed free-surface-pressurized flow --- characteristic implicit method --- relative roughness --- vent holes --- optimization control --- microchannel heat sink --- wavy microchannel --- groove --- heat transfer performance --- laminar flow --- multi-objective optimization --- LHS --- full factorial methods --- pump-turbine --- dynamic stress --- start-up process --- vortex generator (VG) --- computational fluid dynamics (CFD) --- cell-set model --- RANS --- LES --- multistage centrifugal pump --- double-suction impeller --- twin-volute --- inducer-type guide vane --- trailing edge flap (TEF) --- trailing edge flap with Micro-Tab --- deflection angle of the flap (αF) --- n/a --- Reynolds-averaged Navier-Stokes equations