Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

A major source of active compounds, natural products from different sources supply a large variety of molecules that have been approved for clinical use or used as the starting points of optimization programs. This book features nine papers (eight full articles and one review paper) written by more than 45 scientists from around the world. These papers illustrate the development and application of a broad range of computational and experimental techniques applied to natural product research. On behalf of the contributors to the book, our hope is that the research presented here contributes to advancements in the field, and encourages multidisciplinary teams, young scientists, and students to further advance in the discovery of pharmacologically-active natural compounds

n/a --- immunoproteasome --- ginsenoside F1 --- visualization --- chemoinformatics --- soil microorganism --- molecular diversity --- web service --- epigenetics --- bioinsecticides --- Tibetan Plateau --- nanoparticles --- Py-GC/MS --- drug discovery --- consensus diversity plot --- chemical data set --- molecular interactions --- curcumin --- similarity maps --- Alzheimer’s disease --- proteasome inhibitors --- cyclodextrin glycosyltransferase (CGTase) --- classification --- squalene --- docking --- molecular docking --- cholestasis --- protein aggregation --- brain diseases --- structure–activity relationship --- flavonoids --- molecular fingerprints --- cyclodextrin glycosyltransferase --- random forest --- multitarget --- natural products --- inflammation --- natural product-likeness --- chemical space --- epi-informatics --- molecular dynamics --- machine learning --- systematic review --- phenylethanoid glycosides --- ?-glucosyl ginsenoside F1 --- alpine grassland --- Calceolaria --- marine diterpenoid --- Parkinson’s disease --- Alzheimer's disease --- structure-activity relationship --- Parkinson's disease

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

This book has been written with the purpose of providing a vision of a topic which is on the edge of biology and chemistry. As well, we want to provide an updated vision of the potentials and limitations of biocatalysis, especially with respect to applications in processes of organic synthesis, fine chemicals, and medicine. This book pretends to illustrate the potential of an excellent overview of recent progress on the assessment of granted patents as a useful tool in asymmetric synthesis. Some distinguished researchers have contributed to this endeavor with their knowledge, their commitment and their encouragement

Research & information: general --- ferulic acid esters --- octyl ferulate --- esterification --- Box-Behnken design --- response surface methodology --- molar conversion --- optimum condition --- Bacillus --- glycosyltransferase --- 8-hydroxydaidzein --- industrial biotechnology --- electrochemistry --- biohydrogen --- biocatalysis --- process development --- bacteria --- Enantioselectivity --- enzyme cascade --- hydroxynitrile lyase --- lipase --- hydrocyanation --- transesterification --- glycosidases --- transglycosylation --- cyclodextrin glycosyltransferases --- alkyl glucosides --- biosurfactants --- MDR—medium-chain reductase/dehydrogenase --- ADH—alcohol dehydrogenase --- enzyme kinetics --- EDTA (Ethylenediaminetetraacetic acid) chelation --- ultrafiltration --- pseudokinases --- signal transduction --- cancer therapy --- tyrosine/serine/threonine phosphorylation --- new drug targets --- interactome --- asymmetric synthesis --- patents --- lipases --- oxidoreductases --- lyases --- transaminases --- n/a --- MDR-medium-chain reductase/dehydrogenase --- ADH-alcohol dehydrogenase

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

This book has been written with the purpose of providing a vision of a topic which is on the edge of biology and chemistry. As well, we want to provide an updated vision of the potentials and limitations of biocatalysis, especially with respect to applications in processes of organic synthesis, fine chemicals, and medicine. This book pretends to illustrate the potential of an excellent overview of recent progress on the assessment of granted patents as a useful tool in asymmetric synthesis. Some distinguished researchers have contributed to this endeavor with their knowledge, their commitment and their encouragement

Research & information: general --- ferulic acid esters --- octyl ferulate --- esterification --- Box-Behnken design --- response surface methodology --- molar conversion --- optimum condition --- Bacillus --- glycosyltransferase --- 8-hydroxydaidzein --- industrial biotechnology --- electrochemistry --- biohydrogen --- biocatalysis --- process development --- bacteria --- Enantioselectivity --- enzyme cascade --- hydroxynitrile lyase --- lipase --- hydrocyanation --- transesterification --- glycosidases --- transglycosylation --- cyclodextrin glycosyltransferases --- alkyl glucosides --- biosurfactants --- MDR—medium-chain reductase/dehydrogenase --- ADH—alcohol dehydrogenase --- enzyme kinetics --- EDTA (Ethylenediaminetetraacetic acid) chelation --- ultrafiltration --- pseudokinases --- signal transduction --- cancer therapy --- tyrosine/serine/threonine phosphorylation --- new drug targets --- interactome --- asymmetric synthesis --- patents --- lipases --- oxidoreductases --- lyases --- transaminases --- n/a --- MDR-medium-chain reductase/dehydrogenase --- ADH-alcohol dehydrogenase

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

Biocatalysis, the application of enzymes as catalysts for chemical synthesis, has become an increasingly valuable tool for the synthetic chemist. Enzymatic transformations carried out by enzymes or whole-cell catalysts are used for the production of a wide variety of compounds ranging from bulk to fine chemicals. The primary consideration for the incorporation of biotransformation in a synthetic sequence is regio- and stereocontrol that can be achieved with enzyme-catalyzed reactions. Biotransformations are thus becoming accepted as a method for generating optically pure compounds as well as for developing efficient routes to target compounds. This Special Issue aims to address the main applications of biocatalysts, isolated enzymes, and whole microorganisms in the synthesis of bioactive compounds and their precursors.

8-hydroxydaidzein --- stable --- soluble --- anti-inflammation --- amylosucrase --- Deinococcus geothermalis --- coumarin --- biotransformation --- filamentous fungi --- selective hydroxylation --- bromination --- chlorination --- pharmaceuticals --- active agent synthesis --- biocatalysis --- haloperoxidase --- halogenase --- glycosyltransferase --- Glycine max (L.) Merr. --- HPLC/MS --- isoflavone aglycone-rich extract --- isoflavone α-glucoside --- alkene cleavage --- aryl alkenes --- basidiomycota --- carotene degradation --- dye-decolorizing peroxidase (DyP) --- manganese --- Komagataella pfaffii --- Pleurotus sapidus --- monoterpenes --- limonene --- glycerol --- mevalonate pathway --- reaction engineering --- bioprocess --- biocatalyst --- two-liquid phase fermentation --- in situ product removal --- lipase --- unsaturated fatty acid --- oxidative cleavage --- oxidation --- adaptation --- UV/NTG mutagenesis --- psychrotrophs --- terpenes

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

Carbohydrate-active enzymes are responsible for both biosynthesis and the breakdown of carbohydrates and glycoconjugates. They are involved in many metabolic pathways; in the biosynthesis and degradation of various biomolecules, such as bacterial exopolysaccharides, starch, cellulose and lignin; and in the glycosylation of proteins and lipids. Carbohydrate-active enzymes are classified into glycoside hydrolases, glycosyltransferases, polysaccharide lyases, carbohydrate esterases, and enzymes with auxiliary activities (CAZy database, www.cazy.org). Glycosyltransferases synthesize a huge variety of complex carbohydrates with different degrees of polymerization, moieties and branching. On the other hand, complex carbohydrate breakdown is carried out by glycoside hydrolases, polysaccharide lyases and carbohydrate esterases. Their interesting reactions have attracted the attention of researchers across scientific fields, ranging from basic research to biotechnology. Interest in carbohydrate-active enzymes is due not only to their ability to build and degrade biopolymers—which is highly relevant in biotechnology—but also because they are involved in bacterial biofilm formation, and in glycosylation of proteins and lipids, with important health implications. This book gathers new research results and reviews to broaden our understanding of carbohydrate-active enzymes, their mutants and their reaction products at the molecular level.

Research & information: general --- Biology, life sciences --- glycoside hydrolase --- xylanase --- carbohydrate-binding module --- CBM truncation --- halo-tolerant --- xylan hydrolysis --- pectate lyase --- Paenibacillus polymyxa --- pectins --- degradation --- Lactobacillus --- GH13_18 --- sucrose phosphorylase --- glycoside phosphorylase --- Ilumatobacter coccineus --- Thermoanaerobacterium thermosaccharolyticum --- crystallography --- galactosidase --- hydrolysis --- reaction mechanism --- complex structures --- cold-adapted --- GH2 --- Cellulase --- random mutagenesis --- cellulose degradation --- structural analysis --- α-amylase --- starch degradation --- biotechnology --- structure --- pyruvylation --- pyruvyltransferase --- exopolysaccharides --- capsular polysaccharides --- cell wall glycopolymers --- N-glycans --- lipopolysaccharides --- biosynthesis --- sequence space --- pyruvate analytics --- Nanopore sequencing --- ganoderic acid --- Bacillus thuringiensis --- biotransformation --- glycosyltransferase --- whole genome sequencing --- applied biocatalysis --- enzyme cascades --- chemoenzymatic synthesis --- sugar chemistry --- carbohydrate --- Leloir --- nucleotide --- Enzymatic glycosylation --- alkyl glycosides (AG)s --- Deep eutectic solvents (DES) --- Amy A --- alcoholysis --- methanol --- circular dichroism --- protein stability --- alpha-amylase --- biomass --- hemicellulose --- bioethanol --- xylanolytic enzyme --- hemicellulase --- lysozyme --- peptidoglycan cleavage --- avian gut GH22 --- crystal structure --- glycosylation --- UDP-glucose pyrophosphorylase --- UDP-glucose --- nucleotide donors --- Rhodococcus, Actinobacteria, gene redundancy --- Leloir glycosyltransferases --- activated sugar --- UTP --- thermophilic fungus --- β-glucosidases --- Chaetomium thermophilum --- protein structure --- fungal enzymes --- endo-α-(1→6)-d-mannase --- mannoside --- Mycobacterium --- lipomannan --- lipoarabinomannan --- phosphatidylinositol mannosides --- GH68 --- fructosyltransferase --- fructooligosaccharides --- FOS biosynthesis --- prebiotic oligosaccharides --- Arxula adeninivorans --- α-glucosidase --- maltose --- panose --- amylopectin --- glycogen --- inhibition by Tris --- transglycosylation --- glycoside hydrolyase --- Trichoderma harzianum --- complete saccharification --- lignocellulose --- N-acetylhexosamine specificity --- GH20 --- phylogenetic analysis --- NAG-oxazoline --- acceptor diversity --- lacto-N-triose II --- human milk oligosaccharides --- NMR --- molecular phylogeny --- α2,8-sialyltransferases --- polySia motifs --- evolution --- ST8Sia --- functional genomics --- n/a