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Development of new drug molecules is costly and requires longitudinal, wide-ranging studies; therefore, designing advanced pharmaceutical formulations for existing and well-known drugs seems to be an attractive device for the pharmaceutical industry. Properly formulated drug delivery systems can improve pharmacological activity, efficacy and safety of the active substances. Advanced materials applied as pharmaceutical excipients in designing drug delivery systems can help solve problems concerning the required drug release—with the defined dissolution rate and at the determined site. Novel drug carriers enable more effective drug delivery, with improved safety and with fewer side effects. Investigations concerning advanced materials represent a rapidly growing research field in material/polymer science, chemical engineering and pharmaceutical technology. Exploring novel materials or modifying and combining existing ones is now a crucial trend in pharmaceutical technology. Eleven articles included in the the Special Issue “Advanced Materials in Drug Release and Drug Delivery Systems” present the most recent insights into the utilization of different materials with promising potential in drug delivery and into different formulation approaches that can be used in the design of pharmaceutical formulations.

Technology: general issues --- mesoporous silica --- layer-by-layer --- FITC-peptide --- hyaluronic acid --- multilayer film --- host-guest interaction --- total alkaloids from Alstonia scholaris leaves --- mPEG-PLA --- microspheres --- drug release --- biocompatibility --- CO administration --- therapeutic agent --- pharmaceutical drugs --- heme oxygenase --- CO-releasing materials --- CO-releasing molecules --- organometallic complexes --- pharmacokinetic functions --- pathological role --- CO kinetic profile --- cellular targets --- GQDs --- real-time tracking --- optical-magneto nanoparticles --- in vivo --- ethylcellulose --- polymeric material --- cellulose derivative --- pharmaceutical excipient --- hydrogel --- drug delivery --- polymer --- immobilization of drug --- gelatin --- gastro-resistant --- films --- capsules --- structure --- sirolimus --- electrospinning --- polycaprolactone --- 3D matrix --- drug-eluting stents --- spray drying --- microparticles --- rupatadine fumarate --- orodispersible minitablets --- taste masking --- Bicalutamide --- Poloxamer® 407 --- Macrogol 6000 --- supercritical carbon dioxide --- solid dispersions --- dissolution rate --- amorphization --- 3D printing --- fused deposition modeling --- hot-melt extrusion --- solid dosage forms --- itraconazole --- n/a

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Development of new drug molecules is costly and requires longitudinal, wide-ranging studies; therefore, designing advanced pharmaceutical formulations for existing and well-known drugs seems to be an attractive device for the pharmaceutical industry. Properly formulated drug delivery systems can improve pharmacological activity, efficacy and safety of the active substances. Advanced materials applied as pharmaceutical excipients in designing drug delivery systems can help solve problems concerning the required drug release—with the defined dissolution rate and at the determined site. Novel drug carriers enable more effective drug delivery, with improved safety and with fewer side effects. Investigations concerning advanced materials represent a rapidly growing research field in material/polymer science, chemical engineering and pharmaceutical technology. Exploring novel materials or modifying and combining existing ones is now a crucial trend in pharmaceutical technology. Eleven articles included in the the Special Issue “Advanced Materials in Drug Release and Drug Delivery Systems” present the most recent insights into the utilization of different materials with promising potential in drug delivery and into different formulation approaches that can be used in the design of pharmaceutical formulations.

mesoporous silica --- layer-by-layer --- FITC-peptide --- hyaluronic acid --- multilayer film --- host-guest interaction --- total alkaloids from Alstonia scholaris leaves --- mPEG-PLA --- microspheres --- drug release --- biocompatibility --- CO administration --- therapeutic agent --- pharmaceutical drugs --- heme oxygenase --- CO-releasing materials --- CO-releasing molecules --- organometallic complexes --- pharmacokinetic functions --- pathological role --- CO kinetic profile --- cellular targets --- GQDs --- real-time tracking --- optical-magneto nanoparticles --- in vivo --- ethylcellulose --- polymeric material --- cellulose derivative --- pharmaceutical excipient --- hydrogel --- drug delivery --- polymer --- immobilization of drug --- gelatin --- gastro-resistant --- films --- capsules --- structure --- sirolimus --- electrospinning --- polycaprolactone --- 3D matrix --- drug-eluting stents --- spray drying --- microparticles --- rupatadine fumarate --- orodispersible minitablets --- taste masking --- Bicalutamide --- Poloxamer® 407 --- Macrogol 6000 --- supercritical carbon dioxide --- solid dispersions --- dissolution rate --- amorphization --- 3D printing --- fused deposition modeling --- hot-melt extrusion --- solid dosage forms --- itraconazole --- n/a

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Flow analysis is an automatic, precise and fast way to perform analytical tests. Flow instruments are used for clinical and pharmaceutical analyses, quality control of industrial products, monitoring of environmental pollution and many other fields. The book presents the latest methodological, technical and instrumental achievements in flow analysis. It shows new possibilities for the miniaturization and full mechanization of flow systems, together with examples of their interesting application. The proposed solutions contribute to reducing the amount of used reagents and waste, as well as increasing the safety of working with hazardous reagents, resulting in modern devices operating in accordance with the principles of green chemistry. A number of innovative methods of processing and measuring analytical samples have also been described. The book very well reflects the current state of flow analysis and development directions.

Research & information: general --- cholesterol --- serum samples --- lab-on-valve --- automation --- enzymatic reaction --- neonicotinoid --- thiacloprid --- solid-phase spectroscopy --- optosensor --- luminescence --- bioaccessibility --- dog food --- dog nutrition --- dynamic extraction --- flow analysis --- kinetic profile --- zinc --- nuclear waste --- spent nuclear fuel --- ß-emitting nuclides --- 90Sr --- flow injection --- ICP-DRC-MS --- flow synthesis --- flow reactors --- flow-injection analysis --- flow techniques --- radionuclides --- radiochemical separation --- environmental monitoring --- nuclear emergency preparedness --- radioactive waste characterization --- medical isotope production --- titration --- Fe(III), Fe(II) determination --- speciation analysis --- Lab-In-Syringe --- automation of sample pretreatment --- potentials and troubles --- system setup and operation modes --- tips and tricks in method development --- 3D printing of instrument elements --- histidine --- random human urine --- zone fluidics --- o-phthalaldehyde --- derivatization --- stopped-flow --- fluorimetry --- SI-LAV --- mono-segmented flow --- in-line dilution --- in-line single-standard calibration --- in-line standard addition --- albumin --- glucose --- creatinine --- flow method --- chitosan --- catalyst particles --- micron-size --- sampling study --- p-nitrophenol reduction --- preconcentration --- evaporation --- sequential injection analysis --- paired emitter–detector diode detector --- contactless conductivity detector --- flow-based analysis --- simultaneous detection --- sequential detection --- flow chemistry

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The concept of a circular economy relies on waste reduction, valorization, and recycling. Global trends for “green” synthesis of chemicals have positioned the field of enzyme technology and biocatalysis (multi-enzymes and whole-cells) as an alternative for the synthesis of more social- and environmentally-responsible bio-based chemicals. Recent advances in synthetic biology, computational tools, and metabolic engineering have supported the discovery of new enzymes and the rational design of whole-cell biocatalysts. In this book, we highlight these current advances in the field of biocatalysis, with special emphasis on novel enzymes and whole-cell biocatalysts for applications in several industrial biotechnological applications.

Technology: general issues --- 2G ethanol --- hemicellulose usage --- S. cerevisiae --- enzyme immobilization --- cell immobilization --- SHIF --- mannonate dehydratase --- mannose metabolism --- Thermoplasma acidophilum --- mannono-1,4-lactone --- 2-keto-3-deoxygluconate --- aldohexose dehydrogenase --- cyclodextrin glucanotransferases --- large-ring cyclodextrins --- semi rational mutagenesis --- carbohydrate active enzymes --- archaea --- glycosidase --- Sulfolobus solfataricus --- Saccharolobus solfataricus --- Lactobacillus --- β-galactosidase --- immobilization --- cell surface display --- LysM domains --- biocatalysis --- extremophile --- 5-hydroxymethylfurfural --- 5-hydroxymethylfuroic acid --- platform chemicals --- whole cells --- New Delhi metallo-β-lactamase --- NDM-24 --- kinetic profile --- secondary structure --- glycoside hydrolase --- thioglycosides --- Fervidobacterium --- endo-β-1,3-glucanase --- laminarinase --- thermostable --- gene duplication --- cofactor F420 --- deazaflavin --- oxidoreductase --- hydride transfer --- hydrogenation --- asymmetric synthesis --- cofactor biosynthesis --- ω-transaminase --- α-methylbenzylamine --- chiral amine --- biotransformation --- biodiesel --- waste cooking oil --- lipase immobilization --- interfacial activation --- functionalized magnetic nanoparticles --- DNase --- kinetic profiles --- RNase --- semi-rational mutagenesis --- substrate specificity --- engineered Escherichia coli --- flavonoid glucuronides --- multienzyme whole-cell biocatalyst --- organic solvents --- psychrophilic yeast --- hormone-sensitive lipase --- Glaciozyma antarctica --- Antarctica and homology modelling --- keratinase --- serine protease --- metalloprotease --- peptidase --- keratin hydrolysis --- keratin waste --- valorisation --- bioactive peptides --- ene reductase --- enzyme sourcing --- old yellow enzyme --- solvent stability --- machine learning --- flux optimization --- artificial neural network --- synthetic biology --- glycolysis --- metabolic pathways optimization --- cell-free systems --- hydrolase --- lipase --- esterase --- Bacillus subtilis lipase A --- transesterification --- organic solvent --- water activity --- immobilized lipase --- RSM --- fuel properties --- chemo-enzymatic synthesis --- glycosyl transferases --- protein engineering --- carbohydrates --- industrial enzymes --- thermostable enzymes --- glycoside hydrolases --- cell-free biocatalysis --- natural and non-natural multi-enzyme pathways --- bio-based chemicals

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The concept of a circular economy relies on waste reduction, valorization, and recycling. Global trends for “green” synthesis of chemicals have positioned the field of enzyme technology and biocatalysis (multi-enzymes and whole-cells) as an alternative for the synthesis of more social- and environmentally-responsible bio-based chemicals. Recent advances in synthetic biology, computational tools, and metabolic engineering have supported the discovery of new enzymes and the rational design of whole-cell biocatalysts. In this book, we highlight these current advances in the field of biocatalysis, with special emphasis on novel enzymes and whole-cell biocatalysts for applications in several industrial biotechnological applications.

2G ethanol --- hemicellulose usage --- S. cerevisiae --- enzyme immobilization --- cell immobilization --- SHIF --- mannonate dehydratase --- mannose metabolism --- Thermoplasma acidophilum --- mannono-1,4-lactone --- 2-keto-3-deoxygluconate --- aldohexose dehydrogenase --- cyclodextrin glucanotransferases --- large-ring cyclodextrins --- semi rational mutagenesis --- carbohydrate active enzymes --- archaea --- glycosidase --- Sulfolobus solfataricus --- Saccharolobus solfataricus --- Lactobacillus --- β-galactosidase --- immobilization --- cell surface display --- LysM domains --- biocatalysis --- extremophile --- 5-hydroxymethylfurfural --- 5-hydroxymethylfuroic acid --- platform chemicals --- whole cells --- New Delhi metallo-β-lactamase --- NDM-24 --- kinetic profile --- secondary structure --- glycoside hydrolase --- thioglycosides --- Fervidobacterium --- endo-β-1,3-glucanase --- laminarinase --- thermostable --- gene duplication --- cofactor F420 --- deazaflavin --- oxidoreductase --- hydride transfer --- hydrogenation --- asymmetric synthesis --- cofactor biosynthesis --- ω-transaminase --- α-methylbenzylamine --- chiral amine --- biotransformation --- biodiesel --- waste cooking oil --- lipase immobilization --- interfacial activation --- functionalized magnetic nanoparticles --- DNase --- kinetic profiles --- RNase --- semi-rational mutagenesis --- substrate specificity --- engineered Escherichia coli --- flavonoid glucuronides --- multienzyme whole-cell biocatalyst --- organic solvents --- psychrophilic yeast --- hormone-sensitive lipase --- Glaciozyma antarctica --- Antarctica and homology modelling --- keratinase --- serine protease --- metalloprotease --- peptidase --- keratin hydrolysis --- keratin waste --- valorisation --- bioactive peptides --- ene reductase --- enzyme sourcing --- old yellow enzyme --- solvent stability --- machine learning --- flux optimization --- artificial neural network --- synthetic biology --- glycolysis --- metabolic pathways optimization --- cell-free systems --- hydrolase --- lipase --- esterase --- Bacillus subtilis lipase A --- transesterification --- organic solvent --- water activity --- immobilized lipase --- RSM --- fuel properties --- chemo-enzymatic synthesis --- glycosyl transferases --- protein engineering --- carbohydrates --- industrial enzymes --- thermostable enzymes --- glycoside hydrolases --- cell-free biocatalysis --- natural and non-natural multi-enzyme pathways --- bio-based chemicals