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In a number of European countries (e.g., Spain, Italy, France, Portugal, Slovenia, Croatia, Poland), a portion of the pig sector is aimed at the production of traditional and certified products (e.g., PDO—Protected Designation of Origin, PGI—Protected Geographical Indication). Dry-cured ham is probably the most famous traditional pork product; however, typical pork products are produced in (and exported to) many countries worldwide. The meat used for producing these high-quality delicacies needs to be suitable for seasoning and dry-curing, and these characteristics are the result of complex interactions between the animal (breed, genotype, rearing condition, feeding regime, age and weight at slaughter, etc.) and the environment, without disregarding the importance of ethical attributes such as animal welfare and the environmental impact.This Special Issue focuses on all the innovative production strategies for pigs intended for high-quality, typical productions (in term of higher sustainability of the whole production chain, improvement of animal welfare, innovative feeding and farming techniques, reduction in environmental impact, improvement in meat and fat quality, etc.), with emphasis on PDOs, PGIs, and other recognized production schemes, and it is aimed at providing new insights for a wide range of stakeholders from different countries.

Research & information: general --- Biology, life sciences --- Technology, engineering, agriculture --- altitude --- carcass quality --- meat quality --- amino acid --- fatty acid --- natural extract --- curing agents --- sausages --- Cinta Senese pig --- immunocastration --- entire male --- castration --- pig --- dry-cured ham --- Iberian pig --- extensive system --- low-protein diet --- carcass --- fatty-acid profile --- Liangshan pig --- traditional pig products --- swine --- Alentejano --- Bísaro --- Ribatejano --- dorsal subcutaneous fat --- pork quality --- lncIMF4 --- intramuscular preadipocyte --- differentiation --- autophagy --- aggression --- agonistic behavior --- darkness --- light --- mixing --- photoperiod --- regrouping --- skin lesions --- Sus scrofa --- Iberian pork --- quality standard --- qualitative analysis --- in-depth interviews --- adipose tissue --- plasma hormones --- lipogenic enzymes --- fatty acids --- animal welfare --- transport --- stress --- pigs --- pork --- solid-phase microextraction --- mass spectrometry --- aroma --- meat --- genetic marker --- ham processing --- ham quality

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Natural products are bioactive compounds synthesized by terrestrial and marine plants, microorganisms and animals, whose main objective is to prevent them from attacks by predators and/or pathogens. Traditionally since ancient times, different cultures have used these compounds for the prevention and treatment of various human diseases. During the last few years, it has been reported that most of these phytochemicals possess a variety of interesting and significant biological properties, such as analgesic, antiallodynic, antidiabetic, antioxidant, antiparasitic, antimicrobial, antiviral, antiatherogenic, anti-inflammatory, antiproliferative, antitumor and normal growth stimulants, as well as significant cardioprotective and neuroprotective activity. This thematic book aims to collect and disseminate some of the most significant and recent contributions of the use of the natural compounds called phytochemicals, as well as some of their chemical derivatives, for the prevention and treatment of cancer and other accompanying diseases. On the other hand, in recent years, the synthesis of numerous chemical derivatives of these natural compounds has also intensified, with the aim of enhancing their bioactive capacities. Among all these bioactivities, special attention has been paid to its antitumor capacity through the potential modulation of cancer initiation and growth, cell differentiation, apoptosis and autophagy, angiogenesis, and metastatic dissemination. In addition, a considerable number of studies have linked their anticancer effects to their anti-inflammatory and antioxidant activities.

total phenolic content --- total flavonoid content --- GC-MS --- DPPH --- antioxidant --- anticancer agent --- anti-inflammatory agent --- gingival fibroblasts --- oral cancer --- natural extract --- Adenosma bracteosum --- extract --- anti-cancer --- cell line --- isolated compounds --- caspase-3 --- bioactive compounds --- metabolites --- wine --- grapes --- breast cancer --- chemoprevention --- chemotherapy --- squamous cell carcinoma --- Moringa oleifera --- 3-hydroxy-β-ionone --- antioxidant activity --- antioxidant enzymes --- anti-proliferative activity --- maslinic acid --- melanoma --- Olea europaea L. --- ROS levels --- photodynamic therapy --- cancer --- photosensitiser --- natural compounds --- Elaeagnus angustifolia --- EMT --- apoptosis --- AKT/PI3K signaling pathway --- human hepatocarcinoma HepG2 cells --- migration activity --- proliferation --- oxidative stress --- ROS level --- uvaol --- lung metastases --- in vivo --- complementary medicine --- medicinal mushrooms --- triterpenoic acid --- tormentic acid --- betulinic acid --- oleanolic acid --- rhodamine B --- cytotoxicity --- hepatocellular carcinoma (HCC) --- Pogostemon cablin (PPa extract) --- cell cycle --- synergism --- natural photosensitive compounds --- anticancer activity --- hypericin --- emodin --- quinizarin --- danthron --- interaction --- DNA --- glioblastoma (GBM) --- lactucopicrin (LCTP) --- temozolomide (TMZ) --- autophagy --- NF-κB --- p62/SQSM1 --- natural product --- therapeutic triglyceride --- xenograft study --- Caveolin-1 --- actin cytoskeleton --- betulin glycoconjugates --- click chemistry --- 1,3-dipolar cycloaddition --- n/a

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Neurodegenerative diseases, including Alzheimer’s, Parkinson’s, Huntington’s, and amyotrophic lateral sclerosis, are the most common pathologies of the central nervous system currently without a cure. They share common molecular and cellular characteristics, including protein misfolding, mitochondrial dysfunction, glutamate toxicity, dysregulation of calcium homeostasis, oxidative stress, inflammation, and ageing, which contribute to neuronal death. Efforts to treat these diseases are often limited by their multifactorial etiology. Natural products, thanks to their multitarget activities, are considered promising alternatives for the treatment of neurodegeneration. This book deals with two different forms of natural products: extracts and isolated compounds. The study of the bioactivity of the extracts is extremely important as many studies have demonstrated the synergistic effect of the combination of different natural products. On the other hand, the investigation of the activity of specifically isolated natural products can be also important to understand their cellular and molecular mechanisms and to define the specific bioactive components in extracts or foods. This book can be considered an important contribution to knowledge of the neuroprotective effect of natural products and presents a great deal of information, related to both the benefits but also the limitations of their use in counteracting neurodegeneration.

Research & information: general --- Biology, life sciences --- Vitamin D --- Multiple Sclerosis --- symptom --- neurodegeneration --- oxidative injury --- Parkinson’s disease --- terpenes, rotenone --- thymol --- Alzheimer’s disease --- Centella asiatica --- hippocampus --- protein poshophatase 2 --- glycogen synthase kinase 3 --- B-cell lymphoma 2 --- neuroprotection --- nutraceuticals --- bioavailability --- stress response --- neurodegenerative disease --- bioactive compound --- natural extract --- β-amyloid peptide --- tau protein --- clinical trial --- human studies --- animal studies --- in vitro studies --- curcumin --- free radicals --- heme oxygenase --- safety profile --- type 2 diabetes --- inflammation --- vascular damage --- learning --- memory --- natural compound --- oxidative stress --- cognitive dysfunction --- cell death --- synapse loss --- protein aggregation --- neuroinflammation --- algae --- seaweeds --- neurodegenerative diseases --- auraptene --- dopamine neuron --- antioxidant --- mitochondria --- Chionanthus retusus --- flavonoid --- flower --- HO-1 --- NO --- Lippia citriodora --- VEE --- Vs --- relaxation --- depression --- cyclic AMP --- calcium --- blood–brain barrier --- catechin --- cognition --- epigallocatechin gallate --- green tea --- microbiota --- 5-(3,5-dihydroxyphenyl)-γ-valerolactone --- ascaroside pheromone --- C. elegans --- dauer --- neuronal signaling --- sexual behavior --- survival signals --- proteostasis --- chaperones --- autophagy --- ubiquitin-proteasome --- unfolded protein response --- natural compounds --- natural products --- ethics --- patients’ autonomy --- beneficence --- nonmaleficence --- medical liability --- Parkinson’s disease (PD) --- mitochondrial dysfunction --- dynamics --- hormesis --- ubiquitin‒proteasome system (UPS) --- mitophagy --- n/a --- Parkinson's disease --- Alzheimer's disease --- blood-brain barrier --- patients' autonomy --- Parkinson's disease (PD)

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Natural products are bioactive compounds synthesized by terrestrial and marine plants, microorganisms and animals, whose main objective is to prevent them from attacks by predators and/or pathogens. Traditionally since ancient times, different cultures have used these compounds for the prevention and treatment of various human diseases. During the last few years, it has been reported that most of these phytochemicals possess a variety of interesting and significant biological properties, such as analgesic, antiallodynic, antidiabetic, antioxidant, antiparasitic, antimicrobial, antiviral, antiatherogenic, anti-inflammatory, antiproliferative, antitumor and normal growth stimulants, as well as significant cardioprotective and neuroprotective activity. This thematic book aims to collect and disseminate some of the most significant and recent contributions of the use of the natural compounds called phytochemicals, as well as some of their chemical derivatives, for the prevention and treatment of cancer and other accompanying diseases. On the other hand, in recent years, the synthesis of numerous chemical derivatives of these natural compounds has also intensified, with the aim of enhancing their bioactive capacities. Among all these bioactivities, special attention has been paid to its antitumor capacity through the potential modulation of cancer initiation and growth, cell differentiation, apoptosis and autophagy, angiogenesis, and metastatic dissemination. In addition, a considerable number of studies have linked their anticancer effects to their anti-inflammatory and antioxidant activities.

Research & information: general --- total phenolic content --- total flavonoid content --- GC-MS --- DPPH --- antioxidant --- anticancer agent --- anti-inflammatory agent --- gingival fibroblasts --- oral cancer --- natural extract --- Adenosma bracteosum --- extract --- anti-cancer --- cell line --- isolated compounds --- caspase-3 --- bioactive compounds --- metabolites --- wine --- grapes --- breast cancer --- chemoprevention --- chemotherapy --- squamous cell carcinoma --- Moringa oleifera --- 3-hydroxy-β-ionone --- antioxidant activity --- antioxidant enzymes --- anti-proliferative activity --- maslinic acid --- melanoma --- Olea europaea L. --- ROS levels --- photodynamic therapy --- cancer --- photosensitiser --- natural compounds --- Elaeagnus angustifolia --- EMT --- apoptosis --- AKT/PI3K signaling pathway --- human hepatocarcinoma HepG2 cells --- migration activity --- proliferation --- oxidative stress --- ROS level --- uvaol --- lung metastases --- in vivo --- complementary medicine --- medicinal mushrooms --- triterpenoic acid --- tormentic acid --- betulinic acid --- oleanolic acid --- rhodamine B --- cytotoxicity --- hepatocellular carcinoma (HCC) --- Pogostemon cablin (PPa extract) --- cell cycle --- synergism --- natural photosensitive compounds --- anticancer activity --- hypericin --- emodin --- quinizarin --- danthron --- interaction --- DNA --- glioblastoma (GBM) --- lactucopicrin (LCTP) --- temozolomide (TMZ) --- autophagy --- NF-κB --- p62/SQSM1 --- natural product --- therapeutic triglyceride --- xenograft study --- Caveolin-1 --- actin cytoskeleton --- betulin glycoconjugates --- click chemistry --- 1,3-dipolar cycloaddition --- n/a

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In the search for a healthier diet and facing the uncertainties about the consumption of artificial additives, the scientific community has explored in the last years the potential of natural compounds, such as polyphenols, carotenoids, chlorophylls, essential oils, tocopherols, vitamins, polysaccharides, among others, obtained from the most diverse sources, such as plants and fungi, for the replacement of the artificial additives in food, which has made these compounds recognized as “natural additives”. In addition to being considered less harmful to health, and giving a certain functional property to a foodstuff, natural additives can also provide a beneficial synergistic effect in the food matrix. For the consumers, diverse studies have been showed that regular ingestion of bioactive compounds, that can be applied as natural additives, can be helpful for the prevention/treatment of several chronic and aging illnesses, such as cardiovascular diseases and neurological disorders. However, there is much to be researched on the viable use of bioactive compounds and to overcome their chemical limitations so that it can actually be used as natural additives in foods. This book addresses, through 18 scientific articles, some natural compounds with potential for use as preservatives, nutritional additives, coloring agents, flavorings, and various agents.

Technology: general issues --- trisodium citrate --- microbial transglutaminase --- casein gels --- textural properties --- microstructures --- Urtica spp. --- bioactive compounds --- antioxidant activity --- antimicrobial activity --- traditional medicine --- food industry --- animal breeding --- beta cyclodextrin --- ewe’s milk --- cheese --- Manchego --- lipids --- cholesterol --- anthocyanin --- natural extract --- tetraethyl orthosilicate --- black carrot --- black rice flour --- anthocyanins --- low gluten muffins --- added value products --- soymilk --- enzyme modified soymilk --- skim milk --- rennet induced gelation --- rheological properties --- egg yolk --- cholesterol extraction --- granules extraction --- anionic chelating biopolymers --- ADME --- absorption --- chlorophylls --- chlorophyllin --- green colorant --- zinc-chlorophylls --- copper-chlorophyll --- coloring foodstuff --- natural colorants --- food colors --- pomelo peel --- essential oil --- anti-oxidant --- anti-melanogenic --- B16 melanoma cell --- oxygen-containing sulfur flavor molecules --- β-carotene --- bis(2-methyl-3-furyl) disulfide (BMFDS) --- oxidation products --- beetroot --- betalains --- semi-preparative RP-HPLC --- in vitro human gastrointestinal digestion --- ex vivo colon fermentation --- antioxidant ability --- malonildialdehyde --- extra virgin olive oil --- leaf addition --- Tunisian varieties --- phenolics --- tocopherols --- Prunus spinosa L. fruit epicarp --- wild fruit valorization --- cyanidin 3-rutinoside --- peonidin 3-rutinoside --- heat and ultrasound assisted extraction --- response surface methodology --- Ocimum basilicum var. purpurascens leaves --- red rubin basil --- Heat-Assisted Extraction --- extraction optimization --- polyphenols --- tiger nut --- by-products --- solvent extraction --- horchata de chufa --- triple TOF-LC-MS-MS --- Caenorhabditis elegans --- antioxidants --- bergenin --- stress resistance --- lifespan --- Huntington --- uxi --- Endopleura uchi --- Allium cepa red cv. --- Citrus limon --- pickling --- volatiles --- SPME --- chemometrics --- byproducts --- food additives --- antimicrobial --- antioxidant --- colorants --- texturizing agents --- foaming capacity and emulsifiers