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The book contains the refereed contributions from the 45th Annual Meeting of the International Society on Oxygen Transport to Tissue (ISOTT) 2017. This volume covers cross-disciplinary work on a broad range of topics related to the dynamics of oxygen transport: microcirculation and vascular medicine; O2 deficiency and its impact on molecular processes in cells and tissues; cellular metabolism and mitochondrial function; multimodal functional imaging; mathematical modeling; the clinical relevance of oxygen supply as well as therapeutic interventions (e.g. in oncology or critical care medicine). The annual meetings of ISOTT bring together scientists from diverse fields (medicine, physiology, mathematics, biology, chemistry, physics, engineering, etc.) in a unique international forum. The book includes sections on brain oxygenation and function, NIRS oxygenation measurements, tumor oxygenation, cell metabolism, tissue oxygenation and treatment, methodical aspects of O2 measurements and physicochemical aspects of oxygen diffusion. Chapters 3, 24, 49 and 51 of this book are open access under a CC BY 4.0 license.

Oxygen --- Tissue respiration. --- Physiological transport. --- Oxidation, Physiological --- Respiration --- Tissue metabolism --- Delivery of oxygen (Physiology) --- Oxygen delivery (Physiology) --- Oxygen transport (Physiology) --- Medicine. --- Biomedicine general. --- Clinical sciences --- Medical profession --- Human biology --- Life sciences --- Medical sciences --- Pathology --- Physicians --- Health Workforce --- Biomedicine, general.

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This book contains the refereed contributions from the 43rd annual meeting of ISOTT. The annual meetings of ISOTT bring together scientists from various fields (medicine, physiology, mathematics, biology, chemistry, physics, engineering, etc.) in a unique international forum. ISOTT conferences are a place where an atmosphere of interaction is created, where many questions are asked after each presentation and lively discussions occur at a high scientific level. This vivid interaction is the main motivation for members to participate and gain new ideas and knowledge in the broad field of oxygen transport to tissue. The proceedings include sessions covered various research topics including Multi-Modal Imaging/Spectroscopy & Instrumentation; Cancer Metabolism; Cellular Hypoxia and Mitochondrial Function; Brain Oxygenation and Function; Other Organ Function and Metabolism; Oxygen Transport in Sports, Diseases and Clinical Care; Acupuncture, Meridians, and Primo Vascular System; EPR, MRS and MRI.

Medicine. --- Human physiology. --- Immunology. --- Respiratory organs --- Biomedicine. --- Human Physiology. --- Pneumology/Respiratory System. --- Diseases. --- Oxygen --- Physiological transport. --- Delivery of oxygen (Physiology) --- Oxygen delivery (Physiology) --- Oxygen transport (Physiology) --- Pneumology. --- Immunobiology --- Life sciences --- Serology --- Human biology --- Medical sciences --- Physiology --- Human body --- Respiratory organs—Diseases. --- Respiratory diseases

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Following their own brilliant careers in haeme protein research, the outstanding scientists Jonathan and Beatrice Wittenberg continue to provide inspiration to the research community in the study of oxygen-binding proteins. Their research has provided the intellectual stimulus to bring together scientists from all over the world with the common goal of developing fascinating new ideas and performing innovative experiments. This book is dedicated to Jonathan’s and Bea’s lifetime careers. It further illuminates the facts and ideas which dot the paths they traced in Biochemistry and Physiology, elaborating on how these landmark achievements were made and how the haeme proteins community still refers to them. With the field of haeme protein science such a flourishing area, the contributors to this book predict Jonathan and Bea, having played such a seminal role, will continue to be key figures for quite some time to come. Praise for the Wittenbergs and their lasting contributions to research: "Oxygen: a two-atom molecule, but what a wealth of chemistry, and what implications for life! I was always convinced that the deep roots of such a simple statement have constantly inspired the seminal work of the Wittenbergs on the mechanisms of oxygen diffusion and on the varied cellular roles of dozens of different haeme proteins." (Martino Bolognesi) "All of us who study oxygen transport and all who value good science are in their debt." (Ken van Holde) "Beatrice and Jonathan Wittenberg have inspired generations of scientists to explore the mysteries of haeme proteins. Their papers…prompted discussions… in the 1970s and led to investigations on numerous invertebrate myoglobins and haemoglobins…" (Nora Terwilliger) "I was one of many PhD students in the late 1980s who were weaned on the seminal work by the Wittenbergs on myoglobin-facilitated oxygen diffusion. Before reading that article, myoglobin and oxygen diffusion was a mystery to me. With their work, biochemistry and physiology became a dynamic presence in my life." (Cinzia Verde).

Hemoglobin. --- Oxygen --- Physiological transport. --- Delivery of oxygen (Physiology) --- Oxygen delivery (Physiology) --- Oxygen transport (Physiology) --- Hemoglobins --- Hemoglobulin --- Blood --- Blood proteins --- Erythrocytes --- Hemoproteins --- Pigments --- Biochemistry. --- Life sciences. --- Evolution (Biology). --- Microbiology. --- Cytology. --- Protein Science. --- Biochemistry, general. --- Life Sciences, general. --- Evolutionary Biology. --- Cell Biology. --- Cell biology --- Cellular biology --- Biology --- Cells --- Cytologists --- Microbial biology --- Microorganisms --- Animal evolution --- Animals --- Biological evolution --- Darwinism --- Evolutionary biology --- Evolutionary science --- Origin of species --- Evolution --- Biological fitness --- Homoplasy --- Natural selection --- Phylogeny --- Biosciences --- Sciences, Life --- Science --- Biological chemistry --- Chemical composition of organisms --- Organisms --- Physiological chemistry --- Chemistry --- Medical sciences --- Composition --- Proteins . --- Evolutionary biology. --- Cell biology. --- Proteids --- Biomolecules --- Polypeptides --- Proteomics

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Exercise --- Physical Fitness --- Aerobic exercises --- Oxygen --- Physical fitness --- Exercices aérobies --- Oxygène --- Condition physique --- Physiological transport --- Testing --- Transport physiologique --- Tests --- 612:796 --- -Physical fitness --- -Aerobic fitness --- Endurance, Physical --- Fitness, Physical --- Physical endurance --- Physical stamina --- Stamina, Physical --- Health --- Physical education and training --- Sports sciences --- Chalcogens --- Nonmetals --- Photosynthetic oxygen evolution --- Aerobics --- Respiration --- Fysiologie van de sport --- 612:796 Fysiologie van de sport --- Exercices aérobies --- Oxygène --- Aerobic fitness --- Physical capacity --- Ability --- Anthropometry --- Delivery of oxygen (Physiology) --- Oxygen delivery (Physiology) --- Oxygen transport (Physiology) --- Ability testing --- Exercise. --- Physical Fitness.

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This book presents cutting-edge papers and perspectives on the transport of oxygen to tissues by scientists in a multitude of disciplines such as biochemistry, engineering, mathematics, medicine, physics, physiology, veterinary and complementary medicine. The book is composed of the following 6 parts: Brain Oxygenation and Function, Tumor Oxygenation and Metabolism, Muscle Oxygenation and Sports Medicine, Cell Metabolism and Tissue Oxygenation, Methodology of O2 Measurements, and Special Topics. The articles in this book have been presented at the 42nd annual meeting of the International Society on Oxygen Transport to Tissue (ISOTT 2019) held in Albuquerque, New Mexico, USA, from July 28 to July 31, 2019. Academics, clinical and industry researchers, engineers, as well as graduate students who are interested in oxygen transport to tissue will find this book a great reference and a useful learning resource. The chapters "Near-Infrared Spectroscopy Measured Cerebral Blood Flow from Spontaneous Oxygenation Changes in Neonatal Brain Injury", "Developing a Model to Simulate the Effect of Hypothermia on Cerebral Blood Flow and Metabolism" and "Broadband NIRS Cerebral Evaluation of the Hemodynamic and Oxidative State of Cytochrome-c-Oxidase Responses to +Gz Acceleration in Healthy Volunteers" are available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.

Medicine. --- Biomedicine, general. --- Health Workforce --- Oxygen --- Tissue respiration --- Physiological transport --- Physiological transport. --- Delivery of oxygen (Physiology) --- Oxygen delivery (Physiology) --- Oxygen transport (Physiology) --- Chalcogens --- Nonmetals --- Photosynthetic oxygen evolution --- Oxigen en l'organisme --- Teixits (Histologia) --- Fisiologia humana --- Biologia humana --- Ciències de la salut --- Fisiologia --- Mecànica humana --- Reproducció humana --- Cos humà --- Teixits (Biologia) --- Teixits animals --- Teixits humans --- Teixits orgànics --- Cèl·lules i teixits vegetals --- Cultiu de teixits --- Epiteli --- Músculs --- Periodonci --- Teixit nerviós --- Teixit connectiu --- Cèl·lules animals --- Histologia --- Empelts de teixits --- Òrgans (Anatomia) --- Composició del cos humà --- Oximetria --- Anoxèmia --- Medicine --- Biology --- Biomedical Research. --- Research. --- Biological research --- Biomedical research --- Oxygen,