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As users, we require more and more reliable and longer operation of electronic devices. Most often, the efforts of scientists and engineers related to energy management, energy conversion, and energy storage are overlooked. The PowerMEMS slogan in its meaning hides the science of materials enabling the construction of modern accumulators and batteries, so important for the developing consumer electronics and electromobility; energy harvesters used wherever conventional power sources cannot be used; and finally the methods and algorithms of energy processing and management that increase the efficiency of the devices they operate. This Special Issue contains six research papers selected from those presented at the 19th International Conference on Micro and Nanotechnology for Power Generation and Energy Conversion Applications (Power MEMS 2019), as and representative of all papers presented during the Conference.

History of engineering & technology --- coils --- wireless power transfer --- electrically small antennas --- e-textiles --- internet of things --- wireless energy harvesting --- thermoelectrics --- GeTe --- LiI as dopant --- enhanced power factor --- suppressed thermal transport --- triboelectric nanogenerator (TENG) --- mechanical energy harvesting --- single-electrode --- tapping --- flexibility --- porous/rough PDMS --- parylene C --- hermetic packaging --- IoT --- MEMS --- microbattery --- battery --- harvester --- tracker --- wildlifetracking --- heat flux --- thermal resistance --- thermal conductance --- thermal energy harvesting --- endothermic animal --- fur --- 3D printing --- energy harvester

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This Special Issue introduces recent research results on MEMS packaging and 3D integration whose subjects can be divided as follow; three papers on biocompatible implantable packaging, three papers on interconnect, three papers on bonding technologies, one paper on vacuum packaging, and three papers on modeling and simulation.

Research & information: general --- Biology, life sciences --- heterogeneous integration --- wafer bonding --- wafer sealing --- room-temperature bonding --- Au-Au bonding --- surface activated bonding --- Au film thickness --- surface roughness --- microelectromechanical systems (MEMS) packaging --- inkjet printing --- redistribution layers --- capacitive micromachined ultrasound transducers (CMUT) --- fan-out wafer-level packaging (FOWLP) --- adhesion --- thin film metal --- parylene --- neural probe --- scotch tape test --- FEM --- MEMS resonator --- temperature coefficient --- thermal stress --- millimeter-wave --- redundant TSV --- equivalent circuit model --- S-parameters extraction --- technology evaluation --- MEMS and IC integration --- MCDM --- fuzzy AHP --- fuzzy VIKOR --- fan-out wafer-level package --- finite element --- glass substrate --- reliability life --- packaging-on-packaging --- thermal sensors --- TMOS sensor --- finite difference time domain --- optical and electromagnetics simulations --- finite element analysis --- ultrasonic bonding --- metal direct bonding --- microsystem integration --- biocompatible packaging --- implantable --- reliability --- Finite element method (FEM) --- simulation --- multilayer reactive bonding --- integrated nanostructure-multilayer reactive system --- spontaneous self-ignition --- self-propagating exothermic reaction --- Pd/Al reactive multilayer system --- Ni/Al reactive multilayer system --- low-temperature MEMS packaging --- crack propagation --- microbump --- deflection angle --- stress intensity factor (SIF) --- polymer packaging --- neural interface --- chronic implantation --- heterogeneous integration --- wafer bonding --- wafer sealing --- room-temperature bonding --- Au-Au bonding --- surface activated bonding --- Au film thickness --- surface roughness --- microelectromechanical systems (MEMS) packaging --- inkjet printing --- redistribution layers --- capacitive micromachined ultrasound transducers (CMUT) --- fan-out wafer-level packaging (FOWLP) --- adhesion --- thin film metal --- parylene --- neural probe --- scotch tape test --- FEM --- MEMS resonator --- temperature coefficient --- thermal stress --- millimeter-wave --- redundant TSV --- equivalent circuit model --- S-parameters extraction --- technology evaluation --- MEMS and IC integration --- MCDM --- fuzzy AHP --- fuzzy VIKOR --- fan-out wafer-level package --- finite element --- glass substrate --- reliability life --- packaging-on-packaging --- thermal sensors --- TMOS sensor --- finite difference time domain --- optical and electromagnetics simulations --- finite element analysis --- ultrasonic bonding --- metal direct bonding --- microsystem integration --- biocompatible packaging --- implantable --- reliability --- Finite element method (FEM) --- simulation --- multilayer reactive bonding --- integrated nanostructure-multilayer reactive system --- spontaneous self-ignition --- self-propagating exothermic reaction --- Pd/Al reactive multilayer system --- Ni/Al reactive multilayer system --- low-temperature MEMS packaging --- crack propagation --- microbump --- deflection angle --- stress intensity factor (SIF) --- polymer packaging --- neural interface --- chronic implantation

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This Special Issue introduces recent research results on MEMS packaging and 3D integration whose subjects can be divided as follow; three papers on biocompatible implantable packaging, three papers on interconnect, three papers on bonding technologies, one paper on vacuum packaging, and three papers on modeling and simulation.

Research & information: general --- Biology, life sciences --- heterogeneous integration --- wafer bonding --- wafer sealing --- room-temperature bonding --- Au-Au bonding --- surface activated bonding --- Au film thickness --- surface roughness --- microelectromechanical systems (MEMS) packaging --- inkjet printing --- redistribution layers --- capacitive micromachined ultrasound transducers (CMUT) --- fan-out wafer-level packaging (FOWLP) --- adhesion --- thin film metal --- parylene --- neural probe --- scotch tape test --- FEM --- MEMS resonator --- temperature coefficient --- thermal stress --- millimeter-wave --- redundant TSV --- equivalent circuit model --- S-parameters extraction --- technology evaluation --- MEMS and IC integration --- MCDM --- fuzzy AHP --- fuzzy VIKOR --- fan-out wafer-level package --- finite element --- glass substrate --- reliability life --- packaging-on-packaging --- thermal sensors --- TMOS sensor --- finite difference time domain --- optical and electromagnetics simulations --- finite element analysis --- ultrasonic bonding --- metal direct bonding --- microsystem integration --- biocompatible packaging --- implantable --- reliability --- Finite element method (FEM) --- simulation --- multilayer reactive bonding --- integrated nanostructure-multilayer reactive system --- spontaneous self-ignition --- self-propagating exothermic reaction --- Pd/Al reactive multilayer system --- Ni/Al reactive multilayer system --- low-temperature MEMS packaging --- crack propagation --- microbump --- deflection angle --- stress intensity factor (SIF) --- polymer packaging --- neural interface --- chronic implantation --- n/a

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Vision is the most important sense in higher mammals. The retina is the first step in visual processing and the window to the brain. It is not surprising that problems arising in the retina lead to moderate to severe visual impairments. We offer here a collection of reviews as well as original papers dealing with various aspects of retinal function as well as dysfunction. New approaches in retinal research are described, such as the expression and localization of the endocannabinoid system in the normal retina and the role of cannabinoid receptors that could offer new avenues of research in the development of potential treatments for retinal diseases. Moreover, new insights are offered in advancing knowledge towards the prevention and cure of visual pathologies, mainly AMD, RP, and diabetic retinopathy.

Medicine --- Neurosciences --- eye --- retina --- development --- vascularization --- hypoxia --- autophagy --- programmed cell death --- cellular senescence --- retinogenesis --- altricial bird species --- precocial bird species --- senescence-associated galactosidase activity --- diabetes mellitus --- retinopathy --- microvascular --- complication --- optical coherence tomography --- angiography --- black --- African-American --- systemic disease --- biomarker --- retinal degenerative diseases --- mesenchymal stem cells --- stem cell therapy --- experimental models --- clinical trials --- AMD --- age-related macular degeneration --- trichostatin A (TSA) --- HDAC --- histone deacetylase --- vascular endothelial growth factor (VEGF) --- retinal degeneration --- endoplasmic reticulum --- stress response --- unfolded protein response --- GRP78 --- retinal glial cell --- diabetic retinopathy --- zebrafish --- neurovascular unit --- microvascular complications and dysfunction --- metabolism --- motor protein --- myosin 1C --- photoreceptor --- rhodopsin --- outer segments --- visual function --- macroglia --- astrocytes --- Müller cells --- optic nerve crush --- retinal ganglion cells --- spinal cord injury --- signal transducer and activator of transcription 3 --- epidermal growth factor --- Drp1 --- apoptosis --- mitochondria --- microglia --- neurodegeneration --- multiple sclerosis --- retinal microglia --- microglia morphotype --- light damage --- functional analysis --- early detection --- remodeling --- lactate --- GPR81 --- HCAR1 --- growth cone --- dLGN --- axon --- 3,5-DHBA --- kallikrein-kinin system --- kinin receptors --- GFAP --- osteopontin --- retinal detachment --- diabetes --- antioxidants --- bioenergetics --- respiration --- ATP --- glucagon-like peptide-1 --- exendin-4 --- catalase --- immunohistochemistry --- electron microscopy --- Charles Bonnet syndrome --- EEG --- visual hallucination --- resting state --- high-fat diet --- gut microbiome --- gut-retina axis --- RNA sequencing --- germ-free mice --- complement cascade --- angiogenesis --- retinal inflammation --- AII amacrine cell --- Prox1 --- parvalbumin --- gap junction --- eccentricity --- ON/OFF asymmetry --- arterioles --- betulinic acid --- ischemia-reperfusion injury --- reactive oxygen species --- retinal vessels --- retinal fluorescence imaging --- amyloid --- cognitive decline --- Alzheimer's disease --- optic neuritis --- oxidative stress --- neuroprotection --- fingolimod --- iPSC-RPE --- retinal pigment epithelium --- immunodeficient RCS rat --- ultrathin parylene --- retinal transplantation --- CD4+CD25+ --- inflammation --- iPSC --- typical cannabinoid receptors --- atypical cannabinoid receptors --- electroretinography --- monkeys --- visual system --- eye inflammation --- lipopolysaccharide --- natural bioactive extracts --- Ac2-26 --- FPR receptor --- inflammatory mediators --- retinal light injury --- LED screen --- optical filter --- retinal protection --- regeneration --- progenitor cell --- hyperglycemia --- photoreceptors --- neurod --- Notch --- eye --- retina --- development --- vascularization --- hypoxia --- autophagy --- programmed cell death --- cellular senescence --- retinogenesis --- altricial bird species --- precocial bird species --- senescence-associated galactosidase activity --- diabetes mellitus --- retinopathy --- microvascular --- complication --- optical coherence tomography --- angiography --- black --- African-American --- systemic disease --- biomarker --- retinal degenerative diseases --- mesenchymal stem cells --- stem cell therapy --- experimental models --- clinical trials --- AMD --- age-related macular degeneration --- trichostatin A (TSA) --- HDAC --- histone deacetylase --- vascular endothelial growth factor (VEGF) --- retinal degeneration --- endoplasmic reticulum --- stress response --- unfolded protein response --- GRP78 --- retinal glial cell --- diabetic retinopathy --- zebrafish --- neurovascular unit --- microvascular complications and dysfunction --- metabolism --- motor protein --- myosin 1C --- photoreceptor --- rhodopsin --- outer segments --- visual function --- macroglia --- astrocytes --- Müller cells --- optic nerve crush --- retinal ganglion cells --- spinal cord injury --- signal transducer and activator of transcription 3 --- epidermal growth factor --- Drp1 --- apoptosis --- mitochondria --- microglia --- neurodegeneration --- multiple sclerosis --- retinal microglia --- microglia morphotype --- light damage --- functional analysis --- early detection --- remodeling --- lactate --- GPR81 --- HCAR1 --- growth cone --- dLGN --- axon --- 3,5-DHBA --- kallikrein-kinin system --- kinin receptors --- GFAP --- osteopontin --- retinal detachment --- diabetes --- antioxidants --- bioenergetics --- respiration --- ATP --- glucagon-like peptide-1 --- exendin-4 --- catalase --- immunohistochemistry --- electron microscopy --- Charles Bonnet syndrome --- EEG --- visual hallucination --- resting state --- high-fat diet --- gut microbiome --- gut-retina axis --- RNA sequencing --- germ-free mice --- complement cascade --- angiogenesis --- retinal inflammation --- AII amacrine cell --- Prox1 --- parvalbumin --- gap junction --- eccentricity --- ON/OFF asymmetry --- arterioles --- betulinic acid --- ischemia-reperfusion injury --- reactive oxygen species --- retinal vessels --- retinal fluorescence imaging --- amyloid --- cognitive decline --- Alzheimer's disease --- optic neuritis --- oxidative stress --- neuroprotection --- fingolimod --- iPSC-RPE --- retinal pigment epithelium --- immunodeficient RCS rat --- ultrathin parylene --- retinal transplantation --- CD4+CD25+ --- inflammation --- iPSC --- typical cannabinoid receptors --- atypical cannabinoid receptors --- electroretinography --- monkeys --- visual system --- eye inflammation --- lipopolysaccharide --- natural bioactive extracts --- Ac2-26 --- FPR receptor --- inflammatory mediators --- retinal light injury --- LED screen --- optical filter --- retinal protection --- regeneration --- progenitor cell --- hyperglycemia --- photoreceptors --- neurod --- Notch

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Vision is the most important sense in higher mammals. The retina is the first step in visual processing and the window to the brain. It is not surprising that problems arising in the retina lead to moderate to severe visual impairments. We offer here a collection of reviews as well as original papers dealing with various aspects of retinal function as well as dysfunction. New approaches in retinal research are described, such as the expression and localization of the endocannabinoid system in the normal retina and the role of cannabinoid receptors that could offer new avenues of research in the development of potential treatments for retinal diseases. Moreover, new insights are offered in advancing knowledge towards the prevention and cure of visual pathologies, mainly AMD, RP, and diabetic retinopathy.

eye --- retina --- development --- vascularization --- hypoxia --- autophagy --- programmed cell death --- cellular senescence --- retinogenesis --- altricial bird species --- precocial bird species --- senescence-associated galactosidase activity --- diabetes mellitus --- retinopathy --- microvascular --- complication --- optical coherence tomography --- angiography --- black --- African-American --- systemic disease --- biomarker --- retinal degenerative diseases --- mesenchymal stem cells --- stem cell therapy --- experimental models --- clinical trials --- AMD --- age-related macular degeneration --- trichostatin A (TSA) --- HDAC --- histone deacetylase --- vascular endothelial growth factor (VEGF) --- retinal degeneration --- endoplasmic reticulum --- stress response --- unfolded protein response --- GRP78 --- retinal glial cell --- diabetic retinopathy --- zebrafish --- neurovascular unit --- microvascular complications and dysfunction --- metabolism --- motor protein --- myosin 1C --- photoreceptor --- rhodopsin --- outer segments --- visual function --- macroglia --- astrocytes --- Müller cells --- optic nerve crush --- retinal ganglion cells --- spinal cord injury --- signal transducer and activator of transcription 3 --- epidermal growth factor --- Drp1 --- apoptosis --- mitochondria --- microglia --- neurodegeneration --- multiple sclerosis --- retinal microglia --- microglia morphotype --- light damage --- functional analysis --- early detection --- remodeling --- lactate --- GPR81 --- HCAR1 --- growth cone --- dLGN --- axon --- 3,5-DHBA --- kallikrein-kinin system --- kinin receptors --- GFAP --- osteopontin --- retinal detachment --- diabetes --- antioxidants --- bioenergetics --- respiration --- ATP --- glucagon-like peptide-1 --- exendin-4 --- catalase --- immunohistochemistry --- electron microscopy --- Charles Bonnet syndrome --- EEG --- visual hallucination --- resting state --- high-fat diet --- gut microbiome --- gut-retina axis --- RNA sequencing --- germ-free mice --- complement cascade --- angiogenesis --- retinal inflammation --- AII amacrine cell --- Prox1 --- parvalbumin --- gap junction --- eccentricity --- ON/OFF asymmetry --- arterioles --- betulinic acid --- ischemia-reperfusion injury --- reactive oxygen species --- retinal vessels --- retinal fluorescence imaging --- amyloid --- cognitive decline --- Alzheimer’s disease --- optic neuritis --- oxidative stress --- neuroprotection --- fingolimod --- iPSC-RPE --- retinal pigment epithelium --- immunodeficient RCS rat --- ultrathin parylene --- retinal transplantation --- CD4+CD25+ --- inflammation --- iPSC --- typical cannabinoid receptors --- atypical cannabinoid receptors --- electroretinography --- monkeys --- visual system --- eye inflammation --- lipopolysaccharide --- natural bioactive extracts --- Ac2-26 --- FPR receptor --- inflammatory mediators --- retinal light injury --- LED screen --- optical filter --- retinal protection --- regeneration --- progenitor cell --- hyperglycemia --- photoreceptors --- neurod --- Notch --- n/a --- Müller cells --- Alzheimer's disease