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This book presents the major therapeutic applications of modified rice bran arabinoxylan compound (RBAC) in cancer as well as other chronic inflammatory diseases. Written by active researchers and clinicians in the field of RBAC, the chapters cover the basic science that defines the unique function of RBAC as well as the clinical evidence derived through human studies. Particular focus is on recent findings from research over the past decades. This book is both practical and evidence based. It will be a core resource for researchers, students, and practitioners of nutrition and natural medicine, as well as be of value to all healthcare professionals with interest in integrative medicine. .
Cancer --- Diet therapy. --- Treatment. --- Cancer therapy --- Cancer treatment --- Therapy --- Nutritional aspects --- Treatment --- Neoplasms --- Xylans. --- diet therapy. --- Xylan --- Xylan Endo-1,3-beta-Xylosidase
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Numerous efforts have been devoted to using biomass as a feedstock for the production of bio-based materials, biochemicals, and biofuels that reduce greenhouse gas emissions and dependence on conventional fossil resources. Conversion strategies for the production of platform chemicals, building blocks, fine chemicals, and biofuels include a wide range of processes such as chemical and mechanical pretreatment for improved carbohydrate production, fractionation of biomass into carbohydrates and lignin and their further conversions, microbial and enzymatic conversion of biomass into valuable products, and direct catalytic conversion of biomass or its components into chemicals and fuels. This Special Issue introduces recent innovative research results in the area of bioenergy and value-added chemicals from various feedstocks through chemical and biological catalytic processes.
History of engineering & technology --- biomass --- xylan --- lignin --- cellulose --- pretreatment --- solid superacid catalyst --- sulfated tin(IV) oxide --- α-pinene partial coupling --- renewable high-density fuel --- biofuel --- biorefinery --- sugar-decomposed --- enzymatic hydrolysis --- waste biomass --- kinetics --- biomass pre-treatment --- green diesel --- renewable diesel --- Ni catalyst --- hydrodeoxygenation --- Cu-promotion effect --- catalysts --- solvents
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Numerous efforts have been devoted to using biomass as a feedstock for the production of bio-based materials, biochemicals, and biofuels that reduce greenhouse gas emissions and dependence on conventional fossil resources. Conversion strategies for the production of platform chemicals, building blocks, fine chemicals, and biofuels include a wide range of processes such as chemical and mechanical pretreatment for improved carbohydrate production, fractionation of biomass into carbohydrates and lignin and their further conversions, microbial and enzymatic conversion of biomass into valuable products, and direct catalytic conversion of biomass or its components into chemicals and fuels. This Special Issue introduces recent innovative research results in the area of bioenergy and value-added chemicals from various feedstocks through chemical and biological catalytic processes.
History of engineering & technology --- biomass --- xylan --- lignin --- cellulose --- pretreatment --- solid superacid catalyst --- sulfated tin(IV) oxide --- α-pinene partial coupling --- renewable high-density fuel --- biofuel --- biorefinery --- sugar-decomposed --- enzymatic hydrolysis --- waste biomass --- kinetics --- biomass pre-treatment --- green diesel --- renewable diesel --- Ni catalyst --- hydrodeoxygenation --- Cu-promotion effect --- catalysts --- solvents
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Numerous efforts have been devoted to using biomass as a feedstock for the production of bio-based materials, biochemicals, and biofuels that reduce greenhouse gas emissions and dependence on conventional fossil resources. Conversion strategies for the production of platform chemicals, building blocks, fine chemicals, and biofuels include a wide range of processes such as chemical and mechanical pretreatment for improved carbohydrate production, fractionation of biomass into carbohydrates and lignin and their further conversions, microbial and enzymatic conversion of biomass into valuable products, and direct catalytic conversion of biomass or its components into chemicals and fuels. This Special Issue introduces recent innovative research results in the area of bioenergy and value-added chemicals from various feedstocks through chemical and biological catalytic processes.
biomass --- xylan --- lignin --- cellulose --- pretreatment --- solid superacid catalyst --- sulfated tin(IV) oxide --- α-pinene partial coupling --- renewable high-density fuel --- biofuel --- biorefinery --- sugar-decomposed --- enzymatic hydrolysis --- waste biomass --- kinetics --- biomass pre-treatment --- green diesel --- renewable diesel --- Ni catalyst --- hydrodeoxygenation --- Cu-promotion effect --- catalysts --- solvents
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Natural polysaccharides, such as cellulose and chitin, possess unique hierarchical nanoarchitectures that can never be artificially reconstructed, and their nano-organized structures are involved in the hidden materials functions with great potential. Pioneering the emerging functions of nano-organized polysaccharides will break through to achieve the Sustainable Development Goals.
Technology: general issues --- chitin nanofiber --- deacetylated chitin --- nanopaper --- thermal diffusivity --- powder electroluminescent device --- cellulose nanofiber --- paper electronic device --- paper-based light-emitting device --- dehydrogenative polymer --- enzymatic radical coupling --- lignin --- nanocellulose --- microsphere --- TEMPO-oxidized cellulose nanofiber --- chitosan−ZnCl2 complex --- crystal structure --- X-ray fiber diffraction --- nanofibrillated bacterial cellulose --- bacterial cellulose --- peritoneally disseminated gastric cancer --- doxorubicin --- intraperitoneal chemotherapy --- hemicellulose --- xylan --- nanocrystal --- Pickering emulsion --- cellulose derivatives --- cellulose nanocrystal --- cholesteric liquid crystal --- functional materials --- material form --- cellulose nanofibers --- nanocomposite --- xerogel --- flame-retardant --- polydopamine doping --- pyrolysis --- 3D porous nanocarbon --- supercapacitor --- surface carboxylation --- surface deacetylation --- cell culture scaffold --- skin repair --- wound healing --- biomedical applications --- functional nanocomposite --- aqueous process --- sol–gel --- hydrogels --- aerogels --- freeze-drying --- cryogels --- n/a --- sol-gel
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Natural polysaccharides, such as cellulose and chitin, possess unique hierarchical nanoarchitectures that can never be artificially reconstructed, and their nano-organized structures are involved in the hidden materials functions with great potential. Pioneering the emerging functions of nano-organized polysaccharides will break through to achieve the Sustainable Development Goals.
Technology: general issues --- chitin nanofiber --- deacetylated chitin --- nanopaper --- thermal diffusivity --- powder electroluminescent device --- cellulose nanofiber --- paper electronic device --- paper-based light-emitting device --- dehydrogenative polymer --- enzymatic radical coupling --- lignin --- nanocellulose --- microsphere --- TEMPO-oxidized cellulose nanofiber --- chitosan−ZnCl2 complex --- crystal structure --- X-ray fiber diffraction --- nanofibrillated bacterial cellulose --- bacterial cellulose --- peritoneally disseminated gastric cancer --- doxorubicin --- intraperitoneal chemotherapy --- hemicellulose --- xylan --- nanocrystal --- Pickering emulsion --- cellulose derivatives --- cellulose nanocrystal --- cholesteric liquid crystal --- functional materials --- material form --- cellulose nanofibers --- nanocomposite --- xerogel --- flame-retardant --- polydopamine doping --- pyrolysis --- 3D porous nanocarbon --- supercapacitor --- surface carboxylation --- surface deacetylation --- cell culture scaffold --- skin repair --- wound healing --- biomedical applications --- functional nanocomposite --- aqueous process --- sol–gel --- hydrogels --- aerogels --- freeze-drying --- cryogels --- n/a --- sol-gel
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Natural polysaccharides, such as cellulose and chitin, possess unique hierarchical nanoarchitectures that can never be artificially reconstructed, and their nano-organized structures are involved in the hidden materials functions with great potential. Pioneering the emerging functions of nano-organized polysaccharides will break through to achieve the Sustainable Development Goals.
chitin nanofiber --- deacetylated chitin --- nanopaper --- thermal diffusivity --- powder electroluminescent device --- cellulose nanofiber --- paper electronic device --- paper-based light-emitting device --- dehydrogenative polymer --- enzymatic radical coupling --- lignin --- nanocellulose --- microsphere --- TEMPO-oxidized cellulose nanofiber --- chitosan−ZnCl2 complex --- crystal structure --- X-ray fiber diffraction --- nanofibrillated bacterial cellulose --- bacterial cellulose --- peritoneally disseminated gastric cancer --- doxorubicin --- intraperitoneal chemotherapy --- hemicellulose --- xylan --- nanocrystal --- Pickering emulsion --- cellulose derivatives --- cellulose nanocrystal --- cholesteric liquid crystal --- functional materials --- material form --- cellulose nanofibers --- nanocomposite --- xerogel --- flame-retardant --- polydopamine doping --- pyrolysis --- 3D porous nanocarbon --- supercapacitor --- surface carboxylation --- surface deacetylation --- cell culture scaffold --- skin repair --- wound healing --- biomedical applications --- functional nanocomposite --- aqueous process --- sol–gel --- hydrogels --- aerogels --- freeze-drying --- cryogels --- n/a --- sol-gel
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This Brief reports on the interplay of an amino-acid mutation towards substrate which could lead to enhanced effects on mutant. These effects need to be given consideration in the engineering processes of protein stability and further exploration of such learning are required to provide novel indication for selection of an enzymes. There are very few reports showing such stable, energy efficient model towards improved protein function prediction screening in-silico structure based mutagenesis of xylanases from Thermomyces lanuginosus.
Biochemistry. --- Computational biology. --- Life sciences. --- Xylanases -- Biotechnology. --- Computational biology --- Xylanases --- Proteins --- Fungi --- Protein Stability --- Technology, Pharmaceutical --- Glycoside Hydrolases --- Investigative Techniques --- Eukaryota --- Hydrolases --- Amino Acids, Peptides, and Proteins --- Biochemical Phenomena --- Enzymes --- Organisms --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Chemical Phenomena --- Chemicals and Drugs --- Enzymes and Coenzymes --- Phenomena and Processes --- Ascomycota --- Fungal Proteins --- Enzyme Stability --- Xylosidases --- Human Anatomy & Physiology --- Biology --- Health & Biological Sciences --- Biology - General --- Animal Biochemistry --- Biotechnology --- Xylanases. --- Analysis. --- Structure-activity relationships. --- Endoxylanases --- Xylan endoxylosidases --- Proteids --- Proteins. --- Enzymology. --- Bioinformatics. --- Life Sciences. --- Protein Science. --- Bio-informatics --- Biological informatics --- Information science --- Systems biology --- Biochemistry --- Biomolecules --- Polypeptides --- Proteomics --- Biosciences --- Sciences, Life --- Science --- Data processing --- Glycosidases --- Enzymes. --- Biocatalysts --- Ferments --- Soluble ferments --- Catalysts --- Enzymology --- Biological chemistry --- Chemical composition of organisms --- Physiological chemistry --- Chemistry --- Medical sciences --- Composition --- Proteins .
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Carbohydrate-active enzymes are responsible for both biosynthesis and the breakdown of carbohydrates and glycoconjugates. They are involved in many metabolic pathways; in the biosynthesis and degradation of various biomolecules, such as bacterial exopolysaccharides, starch, cellulose and lignin; and in the glycosylation of proteins and lipids. Carbohydrate-active enzymes are classified into glycoside hydrolases, glycosyltransferases, polysaccharide lyases, carbohydrate esterases, and enzymes with auxiliary activities (CAZy database, www.cazy.org). Glycosyltransferases synthesize a huge variety of complex carbohydrates with different degrees of polymerization, moieties and branching. On the other hand, complex carbohydrate breakdown is carried out by glycoside hydrolases, polysaccharide lyases and carbohydrate esterases. Their interesting reactions have attracted the attention of researchers across scientific fields, ranging from basic research to biotechnology. Interest in carbohydrate-active enzymes is due not only to their ability to build and degrade biopolymers—which is highly relevant in biotechnology—but also because they are involved in bacterial biofilm formation, and in glycosylation of proteins and lipids, with important health implications. This book gathers new research results and reviews to broaden our understanding of carbohydrate-active enzymes, their mutants and their reaction products at the molecular level.
Research & information: general --- Biology, life sciences --- glycoside hydrolase --- xylanase --- carbohydrate-binding module --- CBM truncation --- halo-tolerant --- xylan hydrolysis --- pectate lyase --- Paenibacillus polymyxa --- pectins --- degradation --- Lactobacillus --- GH13_18 --- sucrose phosphorylase --- glycoside phosphorylase --- Ilumatobacter coccineus --- Thermoanaerobacterium thermosaccharolyticum --- crystallography --- galactosidase --- hydrolysis --- reaction mechanism --- complex structures --- cold-adapted --- GH2 --- Cellulase --- random mutagenesis --- cellulose degradation --- structural analysis --- α-amylase --- starch degradation --- biotechnology --- structure --- pyruvylation --- pyruvyltransferase --- exopolysaccharides --- capsular polysaccharides --- cell wall glycopolymers --- N-glycans --- lipopolysaccharides --- biosynthesis --- sequence space --- pyruvate analytics --- Nanopore sequencing --- ganoderic acid --- Bacillus thuringiensis --- biotransformation --- glycosyltransferase --- whole genome sequencing --- applied biocatalysis --- enzyme cascades --- chemoenzymatic synthesis --- sugar chemistry --- carbohydrate --- Leloir --- nucleotide --- Enzymatic glycosylation --- alkyl glycosides (AG)s --- Deep eutectic solvents (DES) --- Amy A --- alcoholysis --- methanol --- circular dichroism --- protein stability --- alpha-amylase --- biomass --- hemicellulose --- bioethanol --- xylanolytic enzyme --- hemicellulase --- lysozyme --- peptidoglycan cleavage --- avian gut GH22 --- crystal structure --- glycosylation --- UDP-glucose pyrophosphorylase --- UDP-glucose --- nucleotide donors --- Rhodococcus, Actinobacteria, gene redundancy --- Leloir glycosyltransferases --- activated sugar --- UTP --- thermophilic fungus --- β-glucosidases --- Chaetomium thermophilum --- protein structure --- fungal enzymes --- endo-α-(1→6)-d-mannase --- mannoside --- Mycobacterium --- lipomannan --- lipoarabinomannan --- phosphatidylinositol mannosides --- GH68 --- fructosyltransferase --- fructooligosaccharides --- FOS biosynthesis --- prebiotic oligosaccharides --- Arxula adeninivorans --- α-glucosidase --- maltose --- panose --- amylopectin --- glycogen --- inhibition by Tris --- transglycosylation --- glycoside hydrolyase --- Trichoderma harzianum --- complete saccharification --- lignocellulose --- N-acetylhexosamine specificity --- GH20 --- phylogenetic analysis --- NAG-oxazoline --- acceptor diversity --- lacto-N-triose II --- human milk oligosaccharides --- NMR --- molecular phylogeny --- α2,8-sialyltransferases --- polySia motifs --- evolution --- ST8Sia --- functional genomics --- n/a
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Biocatalysis is very appealing to the industry because it allows, in principle, the synthesis of products not accessible by chemical synthesis. Enzymes are very effective, as are precise biocatalysts, as they are enantioselective, with mild reaction conditions and green chemistry. Biocatalysis is currently widely used in the pharmaceutical industry, food industry, cosmetic industry, and textile industry. This includes enzyme production, biocatalytic process development, biotransformation, enzyme engineering, immobilization, the synthesis of fine chemicals and the recycling of biocatalysts. One of the most challenging problems in biocatalysis applications is process optimization. This Special Issue shows that an optimized biocatalysis process can provide an environmentally friendly, clean, highly efficient, low cost, and renewable process for the synthesis and production of valuable products. With further development and improvements, more biocatalysis processes may be applied in the future.
Research & information: general --- catechin --- degalloylation --- flavonol --- glycoside hydrolase --- optimization --- tannase --- immobilized DERA --- statin side chain --- continuous flow synthesis --- alginate-luffa matrix --- design of experiments --- Anguilla marmorata --- eel protein hydrolysates --- functional properties --- herbal eel extracts --- agarose --- agarase --- agarotriose --- agaropentaose --- expression --- calycosin --- calycosin-7-O-β-D-glucoside --- glucosyltransferase --- sucrose synthase --- UDP-glucose recycle --- UGT–SuSy cascade reaction --- Candida antarctica lipase A --- surface-display system --- shear rate --- mass transfer rate --- enzymatic kinetic study --- enzymatic synthesis --- β-amino acid esters --- microreactor --- aromatic amines --- Michael addition --- kraft pulp --- cellulose --- xylan --- enzymatic hydrolysis --- Penicillium verruculosum --- glucose --- xylose --- lipase --- acidolysis --- docosahexaenoic acid ethyl ester --- eicosapentaenoic acid ethyl ester --- ethyl acetate --- kinetics --- styrene monooxygenase --- indole monooxygenase --- two-component system --- chiral biocatalyst --- solvent tolerance --- biotransformation --- epoxidation --- NAD(P)H-mimics --- superoxide dismutase (SOD) --- catalase (CAT) --- glutathione reductase (GR) --- aluminum (Al) --- selenium (Se) --- mouse --- brain --- liver --- phosphatidylcholine --- 3,4-dimethoxycinnamic acid --- enzymatic interesterification --- biocatalysis --- Pleurotus ostreatus --- enenzymatic hydrolysis --- peptide --- antioxidant --- hepatoprotective activity --- Yarrowia lipolytica --- whole–cell biocatalysis --- indolizine --- cycloaddition --- trehalose --- viscosity --- enzymes --- protein dynamics --- Kramers’ theory --- protein stabilization --- enzyme inhibition --- Lipase --- transesterification --- 2-phenylethyl acetate --- packed-bed reactor --- solvent-free --- cyclic voltammetry --- electrochemical impedance spectroscopy --- carbon nanotubes --- redox mediators --- CYP102A1 --- naringin dihydrochalcone --- neoeriocitrin dihydrochalcone --- regioselective hydroxylation --- n/a --- UGT-SuSy cascade reaction --- whole-cell biocatalysis --- Kramers' theory
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