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In the following years, the world population will keep growing and, simultaneously, there will be more and more chronic diseases. The current hospitalisation infrastructures cannot live up to this changing context and have to rethink to new processes. One of these processes is known as home care. Even if the idea is to propose the same quality of cares at home than at hospital, the home care services have to face different logistic problems. Some of them have already been met in the hospital logistics, some other are entirely new. Therefore, this paper aims at analysing the logistics problems in the home care systems in the Belgian home care systems. To this end, real-life interviews and a review of the scientific literature will be carried out. The main goal is to identify the gaps, if any, that could exist between the literature and the Belgian reality. Moreover, the paper describes the current solutions to problems met in the Belgian home care systems, once again based on the array of interviews that have been carried out. In the literature, we observed four main problems: (1) the network design, (2) the production and suppliers of medicines, (3) the nurses routing, (4) and finally, the management of inventory. Otherwise, this paper suggests a mathematical model for the nurses routing, suitable in the Belgian home care systems. After some interviews with members of Belgian home care systems, we are truly able to say that there is a gap between the literature and the reality. However, those problems are not always developed in the reality when they effectively occur. This paper is divided into five parts. It starts with the presentation of the concept of home care with some details of financing and foreign models. Then, we carry on with the main differences existing between the industrial logistics, hospital logistics and home care logistics, including some comments about information systems and key performance indicators. In addition, we highlight the logistic problems of home care met in the literature such as routing problem, districting problem and also, carry out a comparative analysis of the studied logistic problems. Finally, as a last chapter, we develop the used methods to achieve the goals of this paper.