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Listing 1 - 10 of 1901 << page
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Book
Transplantation of tissues. 1: Cartilage, bone, fascia, tendon, and muscle
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Year: 1955 Publisher: Baltimore (Md.): Williams & Wilkins,

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TRANSPLANTATION


Book
La greffe; aspects biologiques et cliniques : par G. Mathé et J. L. Amiel.
Authors: ---
Year: 1962 Publisher: Paris : Masson,

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Transplantation


Book
Il problema dei trapianti umani
Authors: ---
Year: 1958 Publisher: Roma : Studium,

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Transplantation.


Book
CIBA foundation symposium on transplantation
Authors: ---
Year: 1962 Publisher: London : Churchill,

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Transplantation.


Book
Transplantation d'organes
Authors: --- ---
ISBN: 2225818894 Year: 1990 Publisher: Paris : Masson,

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Book
Overwegingen bij de klinische niertransplantatie : rede uitgesproken bij de aanvaardiging van het ambt van hoogleraar in de urologie an de universiteit van Amsterdam op maandag 25 mei 1970
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ISBN: 9060164091 Year: 1970 Publisher: Leiden Stafleu's Wetenschappelijke Uitgeversmaatschappij

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Pancreas Transplantation : Experimental and Clinical Studies
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ISBN: 3805551029 Year: 1990 Publisher: Basel ; München ; Paris : Karger,

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The occurrence of morbid complications in several organ systems after long-term insulin therapy for diabetes has stimulated renewed interest in pancreas and islet transplantation. Representing the state of the art in this difficult procedure, this monograph compiles the experimental and clinical approach of a single center. Opening chapters outline the clinical aspects of type I diabetes through the history of pancreas transplantation and review the major experimental studies with emphasis on the author’s own work. Recipient and donor selection criteria, all the most currently used techniques of pancreas donor or recipient operation, and patient management and monitoring are then explained and illustrated. Transplantation results are compared to those reported to the International Pancreas Transplant Registry. Current controversies concerning pancreas transplantation with the duct management technique, whole versus segmental grafts, graft preservation, immunosuppression, and patient selection are also discussed.
Thoroughly referenced and containing a wealth of clear illustrations and helpful tables, this comprehensive presentation will be important reading for transplant surgeons, diabetologists, surgeons and nephrologists


Book
Greffe d'organes
Author:
ISBN: 2294009096 Year: 2004 Publisher: Paris : Masson,

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The bridging capacity of a cortical bone defect by different bone grafting materials and diaphyseal distraction lenghthening
Authors: --- --- ---
Year: 1990 Publisher: Bruxelles : UCL,

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Four series of investigations were made on various bone grafting materials and distraction lengthening in cortical bone of adult dogs. Cortical and cancellous bone autografts, non-demineralized and partially HCI-demineralized cortical bone allografts and demineralised allogeneic bone powder were implanted without periosteum and marrow in a three-centimeter cortical bone defect to assess their bridging capacity. Distraction lengthening was applied on the forearm skeleton.
The explanted material was analysed by radiographs, microradiographs, pulse or daily fluorescence labelling, histomorphometry, and mechanical testing for some of them.
One hundred and thirty-five bone grafts and twenty lengthened forearms wereavailable.
From these investigations, several observations were made and can be summarized as follows:
A)Cortical bone autograft
- Bone graft remodelling was already initiated at one month, whether or not the presence of a callus at the anastomotic site.
- Union was achieved in 75% of the anastomotic sites, at six mounts
- In autografts, the intracortical bone resorption an deposition had respectively their peak activities at two and three months after surgery.
- Resoprtion and bone formation had the same temporal pattern in two simultaneous sites of cortical bone defect.
- New bone was deposited on the graft at a slower rate the, in, the bone bed and decreased progressively with the completion of the new haversian systems.
- At nine months, the course of repairs was not fully achieved in autografts as assessed by the porosity level and photon absorptiometric values.
- BMC values of the bone graft was more influenced by the peripheral resorption of the graft than by its porosity level.
- During the course of an autograft incorporation from three to nine months after surgery, the intracortical porosity could influence the mechanical resistance.
B) Cortical bone allografts
- Compared to autografts, allografts were characterized by a marked peripheral resorption which directly influenced the BMC values and the torsinonal strength. Surface bone resorption was more marked in allografts, particularly in the fresh ones, and led to a decreased bone graft diameter with less mechanical resistances. Intracortical porosity was not a distinctive variable among the different bone grafting materials.
- In non-demineralized allografts, new bone was deposited at the same rate as in autografts. Quantitatively, the cumulative new bone index, related to the six-month graft area, was not different from autografts due to the presence of new women bone. However, as the cross-sectional area was greater in autogenous bone, the amount of new bone deposited in autografts was larger in absolute value than in allografts. Lamellar bone formation was earlier and more important in autografts as assessed by the number of double-labeled osteons.
- Creeping-substitution defined as a progressive removal and replacement of non-living bone by new host bone, was the main mechanism in autografts. In allografts, new bone formation resulted also from creeping substitution but in addition, a more extensive removal of cortical bone could occur with its subsequent replacement by new woven bone.
- Autografts were stronger than allografts at six months after surgery because they were less exposed than conventional allografts to a marked peripheral resorption.
- HCI-demineralized segmental allografts were osteoinductive in a fair proportion and responded in an “all-or-nothing” pattern.
- Frozen (-35°C) cortical bone allografts were the most acceptable substitute do autografts when considering their biophysical behaviour compared to the other investigated allografts and the ease of their preservation techniques.
C) Allogeneic inductive bone powder
- Partially HCI-demineralized allogeneic bone powder (200 - 800μ) implanted in the same cortical defect provoked a constant ossification in the gap and in half of the defects, complete bridging with new bone was observed, at six months.
- Membranous ossification was the main mechanism of bone formation. At six months, compaction of the bridging bone was still in progress.
- Autogenous bone marrow supplementation did not appear to influence significantly the final outcome of the inductive material when compared to non-supplemented bone powder.
- At six months, the stage of bone healing was inferior to the one obtained with autogenous cancellous graft used as controls.
- Cancellous bone autografts were found the best bone bridging material in cortical bone defect as they healed without any non-unions and faster than any other bone grafting material.
D) Distraction lengthening of diaphyseal bone
- A directed ossification between two distracted cortical bone segments could be reliably obtained in mature long bones. Most of the new bone arose from a membranous ossification.
- After several days of traction, orientation of the ossification process along the controlled tensile stresses was evident.
- The distracted periosteal and endosteal callus produced a typical pattern of longitudinally-disposed new bone trabeculae growing toward the gap center. From either side, they approached each other and fused.
- Compaction of the new bone was not fully achieved five months after the end of the distraction procedure.
- No evident difference between diaphyseal bone osteotomy and corticotomy emerged as regards to the resulting ossification

Tolérance clinique opérationnelle en transplantation hépatique adulte : expérience de 21 patients des Cliniques universitaires Saint-Luc
Authors: --- ---
Year: 2016 Publisher: Bruxelles : UCL. Faculté de médecine et de médecine dentaire,

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La survie globale des patients transplantés hépatiques (TRH) est inférieure à la population générale, essentiellement à cause des effets secondaires de l'immunosuppression (IS). Actuellement, on sait que jusqu'à 20% des patients hautement sélectionnés sont capables d'atteindre l'immunotolérance acquise ou tolérance clinique opérationnelle (TCO), c'est-à-dire avoir un greffon fonctionnel sans qu'aucune prise d'IS ne soit nécessaire.Analyser les facteurs décrits comme favorisant l'induction de la TCO dans la littérature et voir s'ils sont retrouvés au sein de la cohorte des 21 patients transplantés hépatiques adultes réalisés aux Cliniques universitaires Saint Luc (CUSL) où l'IS a pu être arrêtée.Durant la période de janvier 1984 à décembre 2014, 1011 patients adultes (>16 ans) ont bénéficié d'une TRH aux CUSL. En juin 2015, 21 patients n'avaient pas d'IS pour une durée moyenne de 700 (±1055,8) jours (médiane 861 ; intervalle de 35 à 3147). Parmi les 21 patients, sept sont décédés après une durée moyenne de 5141 (±1913) jours (médiane 4957 ; intervalle de 1902 à 7538). Cette cohorte de patients "tolérants" représente 2,5% (14/569) du total des 569 patients vivants à la fin de l'étude juin 2015) et 3,3% (7/212) du total des 212 patients décédés plus de 1000 jours après leur TRH.En ce qui concerne la TCO, les facteurs concordants à la littérature et retrouvés dans cette cohorte de patients sont : un âge compris entre 50 et 60 ans lors de la TRH, le sexe masculin du receveur, le régime d'IS basé sur les inhibiteurs de la calcineurine (ICN) et un délai 2':10 ans entre la TRH et l'arrêt des IS. Les biopsies de contrôle faites chez 20 patients à 1131,8 (±1133) jours (médiane 890 ; intervalle de 1 à 3147) de l'arrêt de l'IS montrent : un résultat normal chez 9 patients, une stéatose macro-vacuolaire chez 2 patients ; 9 autres patients présentent une inflammation et une fibrose péri-portale légère à modérée.La TCO est devenue une réalité pour un nombre réduit de patients greffés hépatiques adultes. D'autres études seront nécessaires pour mieux déterminer les critères favorisant la TCO afin de sélectionner au mieux les patients transplantés hépatiques pouvant l'atteindre. The global survival of hepatic transplanted patients remains lower than the general population, essentially because of the side effects of immunosuppresive drugs (IS). At present, we know that 20 % of highly selected patients are able to reach a clinical operational tolerance (TCO), which means having a functional transplant without using any IS.To determine if factors presented as favoring the induction of TCO in the medical literature are found within the hepatic adult transplanted group of patients in Cliniques universitaires Saint Luc (CUSL).From January 1984 till December 2014, 1011 adult patients (> 16 years) received a liver transplantation in CUSL. In June 2015, 21 patients had no more IS for an average duration of 700 (±1055,8) days (median 861 ; range of 35 to 3147). Among those 21 patients, seven of them deceased after an average duration of 5141 (±1913) days (median 4957 ; range of 1902 to 7538). This group of 21 "tolerant" patients represents 2,5% (14/569) of the total of 569 alive patients at the end of the study (June 2015) and 3,3% (7/212) of the total of 212 patients deceided more than 1000 days after their TRH.Factors favoring the TCO found in our group of patients and corresponding to the literature are : an age between 50 and 60 years at the TRH, the male sex of the receiver, the regime of IS based on calcineurin inhibitor (ICN) and a duration of l O years between the TRH and the end of the IS. Twenty patients had a liver biopsy (BH) after they stopped their IS for an average period of 1131,8 (±1133) days (median 890 ; range of 1 to 3147) : 9 patients had a normal result, 2 had a macrovacuolar steatosis ; the other 9 patients showed a mild to moderate increase of the periportal inflammation and fibrosis.Clinical tolerance has become a reality for a reduced number of adult patients with a liver transplantation. Other studies will be necessary to better determine criteria favoring TCO in order to select more accurately transplanted patients who can achieve it.

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