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Garantir les conditions du développement et la sécurité sanitaire des produits de thérapies génique et cellulaire
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ISBN: 211100006X Year: 1995 Volume: 53(95-96) Publisher: Paris Imprimerie du Sénat

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Ex vivo cell therapy
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ISBN: 9780126249606 0126249601 Year: 1999 Publisher: [Place of publication not identified] Academic Press

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Over the last two decades advances in the understanding of disease at a cellular and molecular level has led to innovative therapies that are based on the administration of cells which have been modified outside of the body. Ex vivo cell therapy is in essence gene therapy delivered by transfer of therapeutic genes to cells in culture, which are then given to the patient to treat fatal infections such as AIDS, or other conditions such as cancer or genetic diseases. These manipulations include the purification and culture of therapeutic cell subtypes, as well as elimination of cells which cause disease (cancer cells or immune cells reacting to the body itself). Gene therapy can be delivered by transfer of therapeutic genes to cells in culture, which are then given to the patient to treat fatal infections such as AIDS, cancer or genetic diseases. For small-scale laboratory methods to become clinically applicable processes, these new therapies require efficient technologies for cell separation, cell production in culture and gene transfer. This book integrates the recent advances in biological and clinical research with developments in cell-based technologies to provide a comprehensive review for clinicians, researchers, biotechnologists and biomedical engineers working in this rapidly developing area. The biotechnology and pharmaceutical industry requires a broad perspective for development of future technologies, and this text will provide then with an excellent overview of this rapidly evolving field. Key Features * Comprehensive review by leading researchers * Hematopoietic stem cell development: transcriptional control, signaling pathways, hematopoietic growth factors and adhesion molecules * Clinical developments: hematopoietic stem cell transplantation, cellular immunotherapy and gene therapy * Enabling technologies: cell separation, bioreactors, and gene transfer regulatory issues.


Periodical
Journal of gene medicine
Authors: ---
ISSN: 1099498X Publisher: Chichester


Book
L'embryon chez l'homme et l'animal.
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ISBN: 2738009905 2855988047 Year: 2002 Publisher: Paris : INRA : INSERM,

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Philosophes, journalistes, politiques, théologiens, juristes, médecins, biologistes, psychanalystes, tous parlent de l'embryon... Mais qu'est-ce vraiment que l'embryon ? Rassemblant plus de 70 scientifiques de renommée internationale, spécialistes de la biologie du développement, des biotechnologies humaines et animales, de la physiologie et de l'immunologie de la grossesse, de la génétique et de la médecine de la reproduction, cet ouvrage présente une synthèse des connaissances actuelles sur l'embryon humain et animal. Les thèmes abordés - clonage embryonnaire et somatique, transgenèse, thérapie cellulaire, diagnostic génétique pré-implantatoire, développement et évolution, génétique et épigénétique... - donneront aux lecteurs, dans un langage accessible à tous, des éléments de réponse aux questions que font naître la biologie et la médecine d'aujourd'hui.


Periodical
The journal of gene medicine.
Authors: ---
ISSN: 15212254 1099498X Year: 1999 Publisher: New York, NY : Chichester, West Sussex, UK : John Wiley & Sons, John Wiley & Sons, Ltd.

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Keywords

Genetic transformation --- Gene therapy --- Cellular therapy --- Gene Transfer Techniques. --- Genetic Therapy. --- Thérapie génique --- Thérapie cellulaire --- Cellular therapy. --- Gene therapy. --- Genetic transformation. --- Gene Transfer --- Gene Therapy --- Therapy, Gene --- Gene transfer --- Transformation (Genetics) --- DNA Therapy --- Gene Therapy, Somatic --- Genetic Therapy, Gametic --- Genetic Therapy, Somatic --- Therapy, DNA --- Therapy, Somatic Gene --- Somatic Gene Therapy --- Gametic Genetic Therapies --- Gametic Genetic Therapy --- Genetic Therapies --- Genetic Therapies, Gametic --- Genetic Therapies, Somatic --- Somatic Genetic Therapies --- Somatic Genetic Therapy --- Therapies, Gametic Genetic --- Therapies, Genetic --- Therapies, Somatic Genetic --- Therapy, Gametic Genetic --- Therapy, Genetic --- Therapy, Somatic Genetic --- Cell therapy --- Cells --- Therapy, Cellular --- Therapeutic use --- Genetic engineering --- Therapeutics --- Genetic recombination --- Microbial genetics --- Nucleic acids --- Transfection --- Gene Transfer Techniques --- Genetic Services --- Genes, Transgenic, Suicide --- Organotherapy --- Therapeutics, Physiological --- Transplantation of organs, tissues, etc. --- Cell transplantation --- Gene Transfer. --- Gene Delivery Systems --- Gene Transfer Technique --- Transgenesis --- Delivery System, Gene --- Delivery Systems, Gene --- Gene Delivery System --- Technique, Gene Transfer --- Techniques, Gene Transfer --- Transfer Technique, Gene --- Transfer Techniques, Gene --- Genetic Therapy --- Transgenes

Adoptive immunotherapy : methods and protocols
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ISBN: 9781588294067 1588294064 9781592598625 9786610359530 1280359536 1592598625 Year: 2005 Publisher: Totowa, N.J. : Humana Press,

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Over the last decade, major advances in our understanding of the immune system and its mechanisms have led to promising new treatment strategies. In Adoptive Immunotherapy: Methods and Protocols, leading experts describe in detail their optimal techniques for producing and characterizing the immunologically active cells and effector molecules now gaining wide use in the clinical treatment of patients. Taking advantage of the latest technologies, the authors present readily reproducible experimental protocols for the study of dendritic cells, T-cells, monoclonal antibodies, and bone marrow transplantation. The emphasis is on preclinicical and clinical applications and on the progress of selected approaches in clinical trials. Additional chapters cover the molecular definition of target antigens, mathematical modeling approaches to immonotherapy, and the utilization of regulatory T-cells. Theoretical overviews and discussion of future directions for the improvement of adoptive immunotherapy complete the volume. The protocols follow the successful Methods in Molecular Medicine™ series format, each offering step-by-step laboratory instructions, an introduction outlining the principle behind the technique, lists of the necessary equipment and reagents, and tips on troubleshooting and avoiding known pitfalls. Comprehensive and state-of-the-art, Adoptive Immunotherapy: Methods and Protocols offers an authoritative collection of novel techniques to study the adoptive transfer of tailored antigen-specific immune cells and to improve their clinical application.

Keywords

Immunotherapy, Adoptive --- Antibodies --- Cytotoxicity, Immunologic. --- Dendritic Cells. --- Stem Cell Transplantation. --- T-Lymphocytes. --- Cancer --- Cellular therapy. --- Immunocompetent cells --- Thérapie cellulaire --- methods. --- therapeutic use. --- Immunotherapy. --- Therapeutic use. --- Immunothérapie --- Cancer -- Immunotherapy. --- Immunocompetent cells -- Therapeutic use. --- Cellular therapy --- Immune System Processes --- Investigative Techniques --- Epithelial Cells --- Lymphocytes --- Adoptive Transfer --- Mononuclear Phagocyte System --- Immunoglobulins --- Antigen-Presenting Cells --- Cell Transplantation --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Serum Globulins --- Immunization, Passive --- Cells --- Immune System Phenomena --- Immune System --- Leukocytes, Mononuclear --- Transplantation --- Immunoproteins --- Blood Proteins --- Globulins --- Immunization --- Anatomy --- Hemic and Immune Systems --- Leukocytes --- Surgical Procedures, Operative --- Phenomena and Processes --- Proteins --- Blood Cells --- Immunotherapy --- Immunologic Techniques --- Amino Acids, Peptides, and Proteins --- Immunomodulation --- Blood --- Chemicals and Drugs --- Biological Therapy --- Therapeutics --- Methods --- T-Lymphocytes --- Dendritic Cells --- Cytotoxicity, Immunologic --- Stem Cell Transplantation --- Medicine --- Health & Biological Sciences --- Oncology --- Therapeutic use --- Immunologically competent cells --- Cell therapy --- Therapy, Cellular --- Medicine. --- Immunology. --- Biomedicine. --- Immunobiology --- Life sciences --- Serology --- Clinical sciences --- Medical profession --- Human biology --- Medical sciences --- Pathology --- Physicians --- Immune system --- Organotherapy --- Therapeutics, Physiological --- Transplantation of organs, tissues, etc. --- Cell transplantation --- Immunological aspects --- Treatment

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