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In recent years a growing number of proteases have been identified that catalyse peptide bond hydrolysis in the plane of the cellular membrane. These so-called ‘intramembrane-cleaving proteases’ (I-CLiPs) are involved in a diverse range of cellular processes, including cell regulation, signalling, quorum sensing, protein processing, lipid metabolism and the unfolded protein response. Some I-CLiPs play critical roles in diseases such as Alzheimer’s and viral infection. The authors, who are all world leaders in this exciting field of cell biology, provide an overview of the various proteases including recent data derived from the structural determination of some of the I-CliPs, and discuss the various roles that these proteases play in biology and disease. The aim of this book is to provide an update on this emerging group of unusual but important proteases for both the specialist and those with a broader interest in proteases. Amongst the target audience will be protease researchers, enzymologists, those working in academia and the pharmaceutical industry on biological processes and diseases involving I-CLiPs.

Endopeptidases. --- Proteolytic enzymes --- Metabolism. --- Peptide hydrolases --- Proteases --- Hydrolases --- Peptide peptidohydrolases --- Peptidase --- Pathology. --- Neurosciences. --- Cytology. --- Cell Biology. --- Cell biology --- Cellular biology --- Biology --- Cells --- Cytologists --- Neural sciences --- Neurological sciences --- Neuroscience --- Medical sciences --- Nervous system --- Disease (Pathology) --- Diseases --- Medicine --- Medicine, Preventive --- Cell biology.

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Proteases that act in the extracellular environment have been historically associated with tumorigenesis and metastasis by virtue of their ability to carry out "path-clearing" for cancer cells. In the past few years it has become clear that they also shape the pericellular signaling environment, with profound consequences for cell fate and phenotype in both normal development and disease states. The repertoire of proteases that cells and tissues coordinately regulate in order to modulate their local environment is the DEGRADOME – which in humans is represented by at least 569 proteases in five catalytic classes. "The Cancer Degradome: Proteases in Cancer Biology" , edited by Dylan Edwards, Francesco Blasi, Gunilla-Høyer-Hansen and Bonnie Sloane, covers recent knowledge of the composition of the Degradome, how it can be studied using modern approaches such as transcriptomics and mass spectrometry; how protease activity can be imaged both in vitro and in vivo; how gene knockout mice have improved our knowledge of the roles of proteases in cancer; the links that have emerged between proteolysis and cell signaling; how the Degradome can be a useful source of diagnostic and prognostic markers; and finally new approaches to target proteolysis for therapy.

Cancer --- Proteolytic enzymes. --- Molecular aspects. --- Peptide hydrolases --- Proteases --- Hydrolases --- Oncology. --- Human genetics. --- Microbiology. --- Immunology. --- Medical virology. --- Medicine. --- Cancer Research. --- Human Genetics. --- Medical Microbiology. --- Virology. --- Molecular Medicine. --- Clinical sciences --- Medical profession --- Human biology --- Life sciences --- Medical sciences --- Pathology --- Physicians --- Medical microbiology --- Virology --- Virus diseases --- Immunobiology --- Serology --- Microbial biology --- Biology --- Microorganisms --- Genetics --- Heredity, Human --- Physical anthropology --- Tumors --- Health Workforce --- Cancer research. --- Medical microbiology. --- Molecular biology. --- Microbiology --- Cancer research --- Molecular biochemistry --- Molecular biophysics --- Biochemistry --- Biophysics --- Biomolecules --- Systems biology

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Not only do glycerophospholipid, sphingolipid, and cholesterol-derived lipid mediators facilitate the transfer of messages from one cell to another, they also facilitate communication among subcellular organelles. Hot Topics in Neural Membrane Lipidology provides readers with a cutting-edge, comprehensive review of these lipid mediators, their roles and association with neurological disorders, and the future direction of research on the topic. This monograph provides readers with critical data and is particularly accessible to neuroscience graduate students, teachers, and researchers. It can be used as a supplemental text for a range of neuroscience courses. Clinicians and pharmacologists will find this book useful for understanding molecular aspects of lipid mediators in acute neural trauma like stroke, spinal cord trauma, head injury, and neurodegenerative diseases such as Alzheimer disease, Parkinson disease, and Huntington disease. About the Author: Akhlaq A. Farooqui is a leader in the field of brain phospholipases A2, bioactive ether lipid metabolism, and glutamate-mediated neurotoxicity. He has discovered the stimulation of plasmalogen-selective phospholipase A2 activity in brains from patients with Alzheimer disease, and published cutting edge research on the generation and identification of glycerophospholipid, sphingolipid, and cholesterol-derived lipid mediators in kainic acid neurotoxicity. Dr. Farooqui has authored three monographs: Glycerophospholipids in Brain: Phospholipase A2 in Neurological Disorders (2007); Neurochemical Aspects of Excitotoxicity (2008); and Metabolism and Functions of Bioactive Ether Lipids in Brain (2008). All monographs are published by Springer, New York.

Cell membranes. --- Electronic structure --Congresses. --- Membrane lipids. --- Neurons. --- Phospholipases. --- Phospholipids. --- Selenium --Congresses. --- Sphingolipids. --- Tellurium --Congresses. --- Membrane lipids --- Cell membranes --- Neurons --- Sphingolipids --- Phospholipids --- Phospholipases --- Membrane Lipids --- Neurotoxins --- Lipids --- Noxae --- Carboxylic Ester Hydrolases --- Phosphoric Diester Hydrolases --- Esterases --- Toxic Actions --- Chemicals and Drugs --- Hydrolases --- Chemical Actions and Uses --- Enzymes --- Enzymes and Coenzymes --- Animal Biochemistry --- Neurology --- Medicine --- Human Anatomy & Physiology --- Health & Biological Sciences --- Phosphatides --- Nerve cells --- Neurocytes --- Cell surfaces --- Cytoplasmic membranes --- Plasma membranes --- Plasmalemma --- 538.91 <063> --- Biological models --- Modèles biologiques --- Modèles biologiques --- Medicine. --- Neurosciences. --- Neurochemistry. --- Neurology. --- Psychopharmacology. --- Biomedicine. --- 538.93 <063> --- 538.91 <063> Structures, including transitions--Congressen --- Structures, including transitions--Congressen --- 538.93 <063> Transport processes (except in quantum liquids and solids)--Congressen --- Transport processes (except in quantum liquids and solids)--Congressen --- Solid state physics --- Sphingosine --- Phosphates --- Cells --- Nervous system --- Membranes (Biology) --- Glycocalyces --- Endocrinology --- Mathematical models --- Data processing --- Endocrinologie --- Modèles mathématiques --- Behavioral pharmacology --- Drugs --- Chemotherapy --- Pharmacology --- Psychotropic drugs --- Neuropsychiatry --- Biochemistry --- Neurosciences --- Neural sciences --- Neurological sciences --- Neuroscience --- Medical sciences --- Psychotropic effects --- Diseases --- Neurology .

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The Local Cardiac Renin-Angiotensin Aldosterone System, Second Edition updates new findings on the local renin-angiotensin systems (RAS) with a focus on the local RAASs of the cardiovascular system and kidney. Edward D. Frohlich, M.D., M.A.C.P, F.A.C.C., is the Alton Ochsner Distinguished Scientist at the Ochsner Clinic Foundation in New Orleans, Louisiana. He is also Professor of Medicine and of Physiology at Louisiana State University School of Medicine, New Orleans, and Clinical Professor of Medicine and Adjunct Professor of Pharmacology at Tulane University School of Medicine, New Orleans. He is past Editor-in-Chief of the American Heart Association journal HYPERTENSION. Richard N. Re, M.D., is the Section Head, Hypertension at the Ochsner Clinic Foundation in New Orleans, Louisiana. He is also Ochsner's Scientific Director of Research.

Heart -- Physiology. --- Renal hypertension. --- Renin. --- Renin-angiotensin system. --- Renin-angiotensin system --- Hypertension --- Renal hypertension --- Metabolism --- Congresses --- Vacuolar Proton-Translocating ATPases --- Receptors, Cell Surface --- Physiology --- Renin-Angiotensin System --- Proton-Translocating ATPases --- Hemodynamics --- Metabolic Phenomena --- Vascular Diseases --- Publication Formats --- Biological Science Disciplines --- Membrane Proteins --- Natural Science Disciplines --- Publication Characteristics --- ATP Synthetase Complexes --- Cardiovascular Diseases --- Cardiovascular Physiological Processes --- Proteins --- Proton Pumps --- Adenosine Triphosphatases --- Phenomena and Processes --- Diseases --- Disciplines and Occupations --- Cation Transport Proteins --- Acid Anhydride Hydrolases --- Phosphotransferases (Phosphate Group Acceptor) --- Amino Acids, Peptides, and Proteins --- Cardiovascular Physiological Phenomena --- Circulatory and Respiratory Physiological Phenomena --- Chemicals and Drugs --- Phosphotransferases --- Ion Pumps --- Hydrolases --- Transferases --- Membrane Transport Proteins --- Enzymes --- Enzymes and Coenzymes --- Carrier Proteins --- Animal Biochemistry --- Human Anatomy & Physiology --- Medicine --- Health & Biological Sciences --- Heart --- Physiology. --- RA system --- RAA system --- RAAS (Physiology) --- RAS (Physiology) --- Renin-angiotensin-aldosterone axis --- Renin-angiotensin-aldosterone system --- Medicine. --- Cardiology. --- Endocrinology. --- Medicine & Public Health. --- Aldosterone --- Angiotensins --- Renin --- Water-electrolyte balance (Physiology) --- Blood pressure --- Regulation --- Internal medicine --- Hormones --- Endocrinology .

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Protein Phosphatase Protocols presents a broad range of protocols for the study of protein phosphatases, all written by experts and innovators from phosphatase laboratories around the world. This volume is a compendium of resources for the study of protein phosphatases and their potential as drug targets. Experimental methodologies are taken from proteomics, bioinformatics, genomics, biochemistry, RNAi, and genetics. Included protocols utilize several model organisms, including yeast, Drosophila, and various plant and human cells. Protein Phosphatase Protocols provides a concise introduction to protein phosphatase research, with particular attention to phosphatase families. Assays for identification, quantification, purification, and functional characterization are presented throughout in specific detail.

Phosphoprotein phosphatases --- Phosphoprotein Phosphatases --- analysis --- isolation and purification --- Phosphatases. --- Phosphoprotein phosphatases -- Laboratory manuals. --- Phosphoric Monoester Hydrolases --- Phosphoesterases --- Phosphohydrolases --- Phosphoprotein phosphohydrolases --- Protein phosphatases --- Protein phosphoesterases --- Protein phosphohydrolases --- Esterases --- Phosphatases --- Biochemistry. --- Cytology. --- Biochemistry, general. --- Cell Biology. --- Cell biology --- Cellular biology --- Biology --- Cells --- Cytologists --- Biological chemistry --- Chemical composition of organisms --- Organisms --- Physiological chemistry --- Chemistry --- Medical sciences --- Composition --- Phosphoprotein phosphatases - Laboratory manuals --- Phosphoprotein Phosphatases - analysis --- Phosphoprotein Phosphatases - isolation and purification